Rbp4 retinol binding protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbp4provided by RGD
Official Full Name: retinol binding protein 4provided by RGD
Primary source: RGD:3546
See related: AllianceGenome:RGD:3546
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RBPA
Summary: Enables retinol binding activity. Involved in several processes, including response to ethanol; response to muscle activity; and retinol transport. Located in extracellular space. Part of protein-containing complex. Biomarker of atherosclerosis; hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease and type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 26326.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (245306349..245313551, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (235893917..235901315, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (256806476..256813678, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased RBP4 and Asprosin Are Novel Contributors in Inflammation Process of Periodontitis in Obese Rats.
Title: Increased RBP4 and Asprosin Are Novel Contributors in Inflammation Process of Periodontitis in Obese Rats.
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway.
Title: Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway.
RBP4 Is Associated With Insulin Resistance in Hyperuricemia-Induced Rats and Patients With Hyperuricemia.
Title: RBP4 Is Associated With Insulin Resistance in Hyperuricemia-Induced Rats and Patients With Hyperuricemia.
Maternal hypothyroidism during pregnancy alters the function of the retinol-binding protein 4-mediated mitochondrial permeability conversion pore in the kidneys of offspring rats.
Title: Maternal hypothyroidism during pregnancy alters the function of the retinol-binding protein 4-mediated mitochondrial permeability conversion pore in the kidneys of offspring rats.
RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats.
Title: High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism.
plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway
Title: Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation.
Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells.
Title: Retinol binding protein 4 promotes hyperinsulinism‑induced proliferation of rat aortic smooth muscle cells.
Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH.
Title: Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model.
Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma.
Title: Retinol-binding protein 4 and peroxisome proliferator-activated receptor-γ in steatotic liver transplantation.
RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats.
Title: Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinol binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinol binding	IDA Inferred from Direct Assay more info	PubMed
enables retinol binding	IEA Inferred from Electronic Annotation more info
enables retinol binding	ISO Inferred from Sequence Orthology more info
enables retinol transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
involved_in embryonic organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in eye development	IEA Inferred from Electronic Annotation more info
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in female genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula formation	ISO Inferred from Sequence Orthology more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
involved_in maintenance of gastrointestinal epithelium	IEA Inferred from Electronic Annotation more info
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in urinary bladder development	ISO Inferred from Sequence Orthology more info
involved_in uterus development	ISO Inferred from Sequence Orthology more info
involved_in vagina development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vitamin A import into cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: retinol-binding protein 4

Names: PRBP; RBP; plasma retinol-binding protein; retinol binding protein 4, plasma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013162.1 → NP_037294.1 retinol-binding protein 4 precursor

See identical proteins and their annotated locations for NP_037294.1

Status: VALIDATED

Source sequence(s)

CO561550, DV725071

UniProtKB/Swiss-Prot

P04916

UniProtKB/TrEMBL

A0A8I6GFV5, B2RZC1

Conserved Domains (1) summary

cd00743
Location:22 → 192

lipocalin_RBP_like; retinol-binding protein 4 and similar proteins