Kif5b kinesin family member 5B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif5bprovided by RGD
Official Full Name: kinesin family member 5Bprovided by RGD
Primary source: RGD:621559
See related: EnsemblRapid:ENSRNOG00000017466 AllianceGenome:RGD:621559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Khc
Summary: Enables JUN kinase binding activity; microtubule lateral binding activity; and microtubule motor activity. Involved in axonal transport; hippocampus development; and positive regulation of transport. Located in axonal growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Is active in postsynaptic cytosol. Orthologous to human KIF5B (kinesin family member 5B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 897.1), Brain (RPKM 437.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (56185386..56222990)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (51489904..51527508)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (54181416..54219048)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Correlative increasing expressions of KIF5b and Nav1.7 in DRG neurons of rats under neuropathic pain conditions.
Title: Correlative increasing expressions of KIF5b and Nav1.7 in DRG neurons of rats under neuropathic pain conditions.
Kinesin-1-dependent transport of the betaPIX/GIT complex in neuronal cells.
Title: Kinesin-1-dependent transport of the βPIX/GIT complex in neuronal cells.
The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats.
Title: The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats.
High intensity interval training (HIIT) is associated with the down-regulation of gene and protein levels of KIF5B and Dynein in the rat hippocampal tissue, although the underlying mechanisms have remained unknown. These changes suggest that HIIT may have negative effects on both the anterograde and retrograde cytoplasmic transports because the cytoplasmic transport is mediated by KIF5B and Dynein.
Title: High intensity interval training decreases the expressions of KIF5B and Dynein in Hippocampus of Wistar male rats.
clathrin promotes formation of phosphatidylinositol(4,5)diphosphate-enriched microdomains, which are required for clustering of KIF5B.
Title: Kinesin 1 Drives Autolysosome Tubulation.
These results indicate that KIF5B contributes to mitochondrial localization and function in cardiomyocytes and may play a role in pathological hypertrophic responses in vivo.
Title: Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes.
The authors used an in vitro pulldown assay to define a series of five arginine residues within the conserved pUS9 basic domain of herpes simplex virus 1 that were essential for binding the molecular motor kinesin-1.
Title: The Basic Domain of Herpes Simplex Virus 1 pUS9 Recruits Kinesin-1 To Facilitate Egress from Neurons.
Diabetes seems to change spinal cord KIF5B and SYD mRNA and sciatic nerves KIF5B content and exercise training modifies it, which may be attributable to the training-induced decreased hyperglycemia.
Title: Treadmill training modifies KIF5B motor protein in the STZ-induced diabetic rat spinal cord and sciatic nerve.
dysferlin-containing vesicles are transported along microtubles via kinesin heavy chain isoform KIF5B, and undergo rapid microtubule- and KIF5B-dependent fusion to form extremely large vesicles following cellular wounding in skeletal muscle cells.
Title: Membrane damage-induced vesicle-vesicle fusion of dysferlin-containing vesicles in muscle cells requires microtubules and kinesin.
Diabetes increased the expression and immunoreactivity of KIF1A and KIF5B in the hippocampus.
Title: Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule lateral binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in centrosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasm organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoplasm organization	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion transport along microtubule	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrion transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in mitocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitocytosis	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in plus-end-directed vesicle transport along microtubule	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within plus-end-directed vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of voltage-gated sodium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of synapse structure, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of synapse structure, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in retrograde neuronal dense core vesicle transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stress granule disassembly	IEA Inferred from Electronic Annotation more info
involved_in stress granule disassembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle transport along microtubule	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in ciliary rootlet	IEA Inferred from Electronic Annotation more info
located_in ciliary rootlet	ISO Inferred from Sequence Orthology more info
located_in cytolytic granule membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-1 heavy chain

Names: UKHC; conventional kinesin heavy chain; ubiquitous kinesin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057202.2 → NP_476550.1 kinesin-1 heavy chain

See identical proteins and their annotated locations for NP_476550.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q2PQA9, Q9WV65

UniProtKB/TrEMBL

A0A8L2QCP8, A6K9E2

Related

ENSRNOP00000023860.5, ENSRNOT00000023861.8

Conserved Domains (5) summary

smart00129
Location:8 → 332

KISc; Kinesin motor, catalytic domain. ATPase

cd01369
Location:6 → 325

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

pfam05010
Location:467 → 662

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam07851
Location:598 → 686

TMPIT; TMPIT-like protein

pfam14235
Location:462 → 538

DUF4337; Domain of unknown function (DUF4337)