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    Ogn osteoglycin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291015, updated on 9-Dec-2024

    Summary

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    Symbol
    Ognprovided by RGD
    Full Name
    osteoglycinprovided by RGD
    Primary source
    RGD:1308171
    See related
    EnsemblRapid:ENSRNOG00000029792 AllianceGenome:RGD:1308171
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable growth factor activity. Involved in negative regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular matrix. Orthologous to human OGN (osteoglycin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 851.8), Lung (RPKM 538.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ogn in Genome Data Viewer
    Location:
    17p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15238500..15259167, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15032069..15052626, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (14607442..14628274, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene nucleolar protein 8 Neighboring gene centromere protein P Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene osteomodulin Neighboring gene asporin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mimecan is involved in aortic hypertrophy induced by sinoaortic denervation in rats. Gu XS, et al. Mol Cell Biochem, 2011 Jun. PMID 21519924
    2. Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Petretto E, et al. Nat Genet, 2008 May. PMID 18443592, Free PMC Article
    3. Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis. Wang Z, et al. Mol Med Rep, 2021 Jan. PMID 33215216
    4. Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9c2 cardiomyoblasts. de Oliveira G, et al. Gene, 2018 Nov 15. PMID 29990505
    5. Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. Chiasserini D, et al. J Proteomics, 2014 Jun 25. PMID 24769233

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
      Title: Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
    2. Study reveals that Ogn is post-transcriptionally regulated by miR-155 in the maintenance of the cardiac cell morphology in physiological and pathological conditions.
      Title: Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9c2 cardiomyoblasts.
    3. concluded that down-regulation of mimecan was involved in aortic hypertrophy induced by sinoaortic denervation in rats
      Title: Mimecan is involved in aortic hypertrophy induced by sinoaortic denervation in rats.
    4. These data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.
      Title: Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in articular cartilage development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bone development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mimecan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106103.1 → NP_001099573.1  mimecan precursor

      See identical proteins and their annotated locations for NP_001099573.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473977
      UniProtKB/TrEMBL
      A6J6V8, D3ZVB7
      Related
      ENSRNOP00000020532.5, ENSRNOT00000020532.9
      Conserved Domains (2) summary
      sd00033
      Location:123 → 144
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143 → 225
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15238500..15259167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771490.4 → XP_008769712.1  mimecan isoform X1

      See identical proteins and their annotated locations for XP_008769712.1

      UniProtKB/TrEMBL
      A0A1W2Q6Q0
      Related
      ENSRNOP00000110107.1, ENSRNOT00000171835.1
      Conserved Domains (4) summary
      cd00116
      Location:249 → 352
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:229 → 250
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:249 → 331
      LRR_8; Leucine rich repeat
      pfam15376
      Location:167 → 264
      DUF4603; Domain of unknown function (DUF4603)

    2. XM_063276149.1 → XP_063132219.1  mimecan isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q6Q0
    Nucleotide Protein Strain
    Heading Accession and Version

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