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    Fbxo30 F-box protein 30 [ Mus musculus (house mouse) ]

    Gene ID: 71865, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxo30provided by MGI
    Official Full Name
    F-box protein 30provided by MGI
    Primary source
    MGI:MGI:1919115
    See related
    Ensembl:ENSMUSG00000047648 AllianceGenome:MGI:1919115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MUSA1; 1700026A16Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human FBXO30 (F-box protein 30). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 16.8), liver E14 (RPKM 9.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo30 in Genome Data Viewer
    Location:
    10 A1; 10 3.66 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (11157009..11181494)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (11281330..11305750)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930567K20 gene Neighboring gene glutamate receptor, metabotropic 1 Neighboring gene STARR-seq mESC enhancer starr_25749 Neighboring gene STARR-positive B cell enhancer ABC_E9129 Neighboring gene SNF2 histone linker PHD RING helicase Neighboring gene STARR-seq mESC enhancer starr_25751 Neighboring gene STARR-seq mESC enhancer starr_25754 Neighboring gene STARR-seq mESC enhancer starr_25755 Neighboring gene STARR-seq mESC enhancer starr_25756 Neighboring gene STARR-seq mESC enhancer starr_25757 Neighboring gene predicted gene, 25979 Neighboring gene ribosomal protein L17, pseudogene 11 Neighboring gene epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5. Liu Y, et al. Cell Rep, 2016 May 3. PMID 27117404, Free PMC Article
    2. Fbxo30 regulates chromosome segregation of oocyte meiosis. Jin Y, et al. Cell Mol Life Sci, 2019 Jun. PMID 30980108, Free PMC Article
    3. BMP signaling controls muscle mass. Sartori R, et al. Nat Genet, 2013 Nov. PMID 24076600
    4. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 30
    Names
    muscle ubiquitin ligase of SCF complex in atrophy-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168297.1 → NP_001161769.1  F-box only protein 30

      See identical proteins and their annotated locations for NP_001161769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC167234, AK006369, AK047174, AK083479, AK135274
      Consensus CDS
      CCDS23697.1
      UniProtKB/Swiss-Prot
      Q3UXU4, Q8BJL1, Q8CI21, Q9D9X5
      Related
      ENSMUSP00000068230.5, ENSMUST00000070300.5
      Conserved Domains (2) summary
      pfam15965
      Location:8 → 100
      zf-TRAF_2; TRAF-like zinc-finger
      pfam15966
      Location:614 → 722
      F-box_4

    2. NM_027968.3 → NP_082244.2  F-box only protein 30

      See identical proteins and their annotated locations for NP_082244.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC167234, AK047174, AK083479, AK135274
      Consensus CDS
      CCDS23697.1
      UniProtKB/Swiss-Prot
      Q3UXU4, Q8BJL1, Q8CI21, Q9D9X5
      Related
      ENSMUSP00000117687.2, ENSMUST00000129456.8
      Conserved Domains (2) summary
      pfam15965
      Location:8 → 100
      zf-TRAF_2; TRAF-like zinc-finger
      pfam15966
      Location:614 → 722
      F-box_4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      11157009..11181494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156027.1 → XP_036011920.1  F-box only protein 30 isoform X2

      Conserved Domains (2) summary
      pfam15965
      Location:8 → 100
      zf-TRAF_2; TRAF-like zinc-finger
      cl02535
      Location:612 → 679
      F-box-like

    2. XM_006512859.5 → XP_006512922.1  F-box only protein 30 isoform X1

      See identical proteins and their annotated locations for XP_006512922.1

      UniProtKB/Swiss-Prot
      Q3UXU4, Q8BJL1, Q8CI21, Q9D9X5
      Conserved Domains (2) summary
      pfam15965
      Location:8 → 100
      zf-TRAF_2; TRAF-like zinc-finger
      pfam15966
      Location:614 → 722
      F-box_4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJL1.2 GenPept UniProtKB/Swiss-Prot:Q8BJL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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