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    EPB41L3 erythrocyte membrane protein band 4.1 like 3 [ Homo sapiens (human) ]

    Gene ID: 23136, updated on 27-Nov-2024

    Summary

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    Official Symbol
    EPB41L3provided by HGNC
    Official Full Name
    erythrocyte membrane protein band 4.1 like 3provided by HGNC
    Primary source
    HGNC:HGNC:3380
    See related
    Ensembl:ENSG00000082397 MIM:605331; AllianceGenome:HGNC:3380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    4.1B; DAL1; DAL-1
    Summary
    Predicted to enable cytoskeletal protein-membrane anchor activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including nervous system development; paranodal junction maintenance; and protein localization to axon. Located in cell-cell junction and plasma membrane. Implicated in esophagus squamous cell carcinoma. Biomarker of meningioma. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 28.0), testis (RPKM 24.6) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EPB41L3 in Genome Data Viewer
    Location:
    18p11.31
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (5392386..5630663, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (5552548..5790830, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (5392385..5630662, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13056 Neighboring gene uncharacterized LOC105371970 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:5395432-5396631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:5456406-5456906 Neighboring gene uncharacterized LOC107985145 Neighboring gene NANOG hESC enhancer GRCh37_chr18:5624822-5625323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:5629686-5630190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9263 Neighboring gene NANOG hESC enhancer GRCh37_chr18:5678118-5678619 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:5684410-5684994 Neighboring gene NANOG hESC enhancer GRCh37_chr18:5733383-5733915 Neighboring gene MIR3976 host gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9264 Neighboring gene microRNA 3976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:5891299-5891826 Neighboring gene uncharacterized LOC121725015 Neighboring gene transmembrane protein 200C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DAL-1/4.1B contributes to epithelial-mesenchymal transition via regulation of transforming growth factor-β in lung cancer cell lines. Yu F, et al. Mol Med Rep, 2015 Oct. PMID 26300315
    2. The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China. Wang H, et al. BMC Gastroenterol, 2021 Sep 27. PMID 34579655, Free PMC Article
    3. Potential role of EPB41L3 (protein 4.1B/Dal-1) as a target for treatment of advanced prostate cancer. Bernkopf DB, et al. Expert Opin Ther Targets, 2008 Jul. PMID 18554153
    4. Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition. Yuan X, et al. Aging (Albany NY), 2020 Dec 11. PMID 33323539, Free PMC Article
    5. Inactivation patterns of NF2 and DAL-1/4.1B (EPB41L3) in sporadic meningioma. Nunes F, et al. Cancer Genet Cytogenet, 2005 Oct 15. PMID 16213361

    See all (181) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methylation of HPV16 and EPB41L3 in oral gargles and the detection of early and late oropharyngeal cancer.
      Title: Methylation of HPV16 and EPB41L3 in oral gargles and the detection of early and late oropharyngeal cancer.
    2. Over-expression of EPB41L3 promotes apoptosis of human cervical carcinoma cells through PI3K/AKT signaling.
      Title: Over-expression of EPB41L3 promotes apoptosis of human cervical carcinoma cells through PI3K/AKT signaling.
    3. DAL-1/4.1B promotes the uptake of exosomes in lung cancer cells via Heparan Sulfate Proteoglycan 2 (HSPG2).
      Title: DAL-1/4.1B promotes the uptake of exosomes in lung cancer cells via Heparan Sulfate Proteoglycan 2 (HSPG2).
    4. The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China.
      Title: The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China.
    5. Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition.
      Title: Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition.
    6. DNA methylation for cervical cancer screening: a training set in China.
      Title: DNA methylation for cervical cancer screening: a training set in China.
    7. Mutation and Expression of a Candidate Tumor Suppressor Gene EPB41L3 in Gastric and Colorectal Cancers.
      Title: Mutation and Expression of a Candidate Tumor Suppressor Gene EPB41L3 in Gastric and Colorectal Cancers.
    8. miR-452 promotes the development of gastric cancer via targeting EPB41L3.
      Title: miR-452 promotes the development of gastric cancer via targeting EPB41L3.
    9. 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment
      Title: 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment.
    10. Quantitative methylation results indicated that the level of methylation was significantly higher (hypermethylated) for FLT3 and EPB41L3 and significantly lower (hypomethylated) for SFN in tumour tissues as compared to the adjacent paired normal tissue.
      Title: Promoter-associated DNA methylation & expression profiling of genes (FLT 3, EPB41L3 & SFN) in patients with oral squamous cell carcinoma in the Khasi & Jaintia population of Meghalaya, India.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated erythrocyte membrane protein band 4.1-like 3 (EPB41L3) protein is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37633, KIAA0987

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein-membrane anchor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in myelin maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in paranodal junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to juxtaparanode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to paranode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with axolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in juxtaparanode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in paranode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 3
    Names
    differentially expressed in adenocarcinoma of the lung protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281533.2 → NP_001268462.1  band 4.1-like protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different 5' non-coding exon, uses an alternate in-frame acceptor splice site at an internal exon, and lacks 2 exons in the 3' coding region, the latter of which causes a frame-shift compared to variant 1. The resulting isoform (2) is shorter with a distinct C-terminus compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
      Source sequence(s)
      AP005059, AP005671
      Consensus CDS
      CCDS62382.1
      UniProtKB/TrEMBL
      B3KY28
      Related
      ENSP00000441174.1, ENST00000544123.5
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:548 → 596
      SAB; SAB domain
      pfam05902
      Location:805 → 883
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    2. NM_001281534.3 → NP_001268463.1  band 4.1-like protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001268463.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site at an internal exon, and lacks 3 non-consecutive in-frame coding exons compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1.
      Source sequence(s)
      AP005059, AP005671
      Consensus CDS
      CCDS62381.1
      UniProtKB/TrEMBL
      B3KY28
      Related
      ENSP00000442091.2, ENST00000540638.6
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:537 → 582
      SAB; SAB domain
      pfam05902
      Location:752 → 857
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 439
      FA; FERM adjacent (FA)

    3. NM_001281535.2 → NP_001268464.1  band 4.1-like protein 3 isoform 4

      See identical proteins and their annotated locations for NP_001268464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate promoter, differs in the 5' UTR, initiates translation from an in-frame downstream start codon, uses an alternate in-frame acceptor splice site at an internal exon, and lacks 3 non-consecutive in-frame coding exons compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1. Variants 4 and 7 both encode the same isoform (4).
      Source sequence(s)
      AP001032, AP005059, AP005671
      Consensus CDS
      CCDS82236.1
      UniProtKB/TrEMBL
      A8K968, B3KY28
      Related
      ENSP00000488626.1, ENST00000545076.5
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:428 → 475
      SAB; SAB domain
      pfam05902
      Location:643 → 748
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    4. NM_001330557.2 → NP_001317486.1  band 4.1-like protein 3 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 8, encodes isoform 5.
      Source sequence(s)
      AP005059, AP005671
      Consensus CDS
      CCDS82237.1
      UniProtKB/TrEMBL
      A0A0A0MRA8, B3KY28
      Related
      ENSP00000341138.4, ENST00000342933.7
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:548 → 596
      SAB; SAB domain
      pfam05902
      Location:805 → 910
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    5. NM_001384682.1 → NP_001371611.1  band 4.1-like protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AP005059, AP005671
      Consensus CDS
      CCDS62382.1
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:548 → 596
      SAB; SAB domain
      pfam05902
      Location:805 → 883
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    6. NM_001384683.1 → NP_001371612.1  band 4.1-like protein 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 4, encodes isoform 4.
      Source sequence(s)
      AP001032, AP005059, AP005671
      Consensus CDS
      CCDS82236.1
      UniProtKB/TrEMBL
      A8K968, B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:428 → 475
      SAB; SAB domain
      pfam05902
      Location:643 → 748
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    7. NM_001384684.1 → NP_001371613.1  band 4.1-like protein 3 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 5, encodes isoform 5.
      Source sequence(s)
      AP005059, AP005671
      Consensus CDS
      CCDS82237.1
      UniProtKB/TrEMBL
      A0A0A0MRA8, B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:548 → 596
      SAB; SAB domain
      pfam05902
      Location:805 → 910
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    8. NM_001384685.1 → NP_001371614.1  band 4.1-like protein 3 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) represents the longest transcript and encodes the longest isoform (6).
      Source sequence(s)
      AP005059, AP005671
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:735 → 783
      SAB; SAB domain
      pfam05902
      Location:992 → 1097
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    9. NM_001384686.1 → NP_001371615.1  band 4.1-like protein 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:537 → 584
      SAB; SAB domain
      pfam05902
      Location:793 → 898
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    10. NM_001384687.1 → NP_001371616.1  band 4.1-like protein 3 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variant 12, encodes isoform 8.
      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:530 → 578
      SAB; SAB domain
      pfam05902
      Location:787 → 892
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    11. NM_001384688.1 → NP_001371617.1  band 4.1-like protein 3 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variant 11, encodes isoform 8.
      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:530 → 578
      SAB; SAB domain
      pfam05902
      Location:787 → 892
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    12. NM_001384689.1 → NP_001371618.1  band 4.1-like protein 3 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variant 14, encodes isoform 9.
      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:548 → 596
      SAB; SAB domain
      pfam05902
      Location:805 → 883
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    13. NM_001384690.1 → NP_001371619.1  band 4.1-like protein 3 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variant 13, encodes isoform 9.
      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:548 → 596
      SAB; SAB domain
      pfam05902
      Location:805 → 883
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    14. NM_001384691.1 → NP_001371620.1  band 4.1-like protein 3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:548 → 596
      SAB; SAB domain
      pfam05902
      Location:764 → 869
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    15. NM_001384692.1 → NP_001371621.1  band 4.1-like protein 3 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:530 → 578
      SAB; SAB domain
      pfam05902
      Location:787 → 865
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    16. NM_001384693.1 → NP_001371622.1  band 4.1-like protein 3 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:537 → 584
      SAB; SAB domain
      pfam05902
      Location:756 → 861
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    17. NM_001384694.1 → NP_001371623.1  band 4.1-like protein 3 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:530 → 578
      SAB; SAB domain
      pfam05902
      Location:787 → 865
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    18. NM_001384695.1 → NP_001371624.1  band 4.1-like protein 3 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:548 → 596
      SAB; SAB domain
      pfam05902
      Location:764 → 842
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    19. NM_001384696.1 → NP_001371625.1  band 4.1-like protein 3 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:519 → 566
      SAB; SAB domain
      pfam05902
      Location:734 → 839
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    20. NM_001384697.1 → NP_001371626.1  band 4.1-like protein 3 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:537 → 584
      SAB; SAB domain
      pfam05902
      Location:752 → 830
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 441
      FA; FERM adjacent (FA)

    21. NM_001384698.1 → NP_001371627.1  band 4.1-like protein 3 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:439 → 487
      SAB; SAB domain
      pfam05902
      Location:696 → 801
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    22. NM_001384699.1 → NP_001371628.1  band 4.1-like protein 3 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:428 → 475
      SAB; SAB domain
      pfam05902
      Location:684 → 789
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    23. NM_001384700.1 → NP_001371629.1  band 4.1-like protein 3 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:421 → 469
      SAB; SAB domain
      pfam05902
      Location:678 → 783
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    24. NM_001384701.1 → NP_001371630.1  band 4.1-like protein 3 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:439 → 487
      SAB; SAB domain
      pfam05902
      Location:696 → 774
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    25. NM_001384702.1 → NP_001371631.1  band 4.1-like protein 3 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:410 → 457
      SAB; SAB domain
      pfam05902
      Location:666 → 771
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    26. NM_001384703.1 → NP_001371632.1  band 4.1-like protein 3 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:439 → 487
      SAB; SAB domain
      pfam05902
      Location:696 → 774
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    27. NM_001384704.1 → NP_001371633.1  band 4.1-like protein 3 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:439 → 487
      SAB; SAB domain
      pfam05902
      Location:655 → 760
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    28. NM_001384705.1 → NP_001371634.1  band 4.1-like protein 3 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:421 → 469
      SAB; SAB domain
      pfam05902
      Location:678 → 756
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    29. NM_001384706.1 → NP_001371635.1  band 4.1-like protein 3 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AP001032, AP005059, AP005671
      UniProtKB/TrEMBL
      B3KY28
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:421 → 469
      SAB; SAB domain
      pfam05902
      Location:637 → 742
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 332
      FA; FERM adjacent (FA)

    30. NM_012307.5 → NP_036439.2  band 4.1-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_036439.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AP005059, AP005671
      Consensus CDS
      CCDS11838.1
      UniProtKB/Swiss-Prot
      B7Z4I5, F5GX05, O95713, Q9BRP5, Q9Y2J2
      Related
      ENSP00000343158.2, ENST00000341928.7
      Conserved Domains (7) summary
      smart00295
      Location:112 → 301
      B41; Band 4.1 homologues
      cd13184
      Location:296 → 389
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:196 → 301
      FERM_M; FERM central domain
      pfam04382
      Location:717 → 763
      SAB; SAB domain
      pfam05902
      Location:974 → 1079
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:398 → 438
      FA; FERM adjacent (FA)
      pfam09379
      Location:114 → 174
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      5392386..5630663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437384.1 → XP_047293340.1  band 4.1-like protein 3 isoform X31

    2. XM_047437372.1 → XP_047293328.1  band 4.1-like protein 3 isoform X15

    3. XM_047437382.1 → XP_047293338.1  band 4.1-like protein 3 isoform X29

    4. XM_047437383.1 → XP_047293339.1  band 4.1-like protein 3 isoform X30

    5. XM_047437381.1 → XP_047293337.1  band 4.1-like protein 3 isoform X28

    6. XM_047437378.1 → XP_047293334.1  band 4.1-like protein 3 isoform X25

    7. XM_047437380.1 → XP_047293336.1  band 4.1-like protein 3 isoform X27

    8. XM_017025631.2 → XP_016881120.1  band 4.1-like protein 3 isoform X23

      UniProtKB/TrEMBL
      B3KY28

    9. XM_017025626.2 → XP_016881115.1  band 4.1-like protein 3 isoform X21

      UniProtKB/TrEMBL
      B3KY28

    10. XM_017025619.2 → XP_016881108.1  band 4.1-like protein 3 isoform X17

      UniProtKB/TrEMBL
      B3KY28

    11. XM_047437368.1 → XP_047293324.1  band 4.1-like protein 3 isoform X11

    12. XM_047437364.1 → XP_047293320.1  band 4.1-like protein 3 isoform X7

    13. XM_047437367.1 → XP_047293323.1  band 4.1-like protein 3 isoform X10

    14. XM_047437366.1 → XP_047293322.1  band 4.1-like protein 3 isoform X9

    15. XM_047437361.1 → XP_047293317.1  band 4.1-like protein 3 isoform X4

    16. XM_047437370.1 → XP_047293326.1  band 4.1-like protein 3 isoform X13

    17. XM_047437379.1 → XP_047293335.1  band 4.1-like protein 3 isoform X26

    18. XM_047437369.1 → XP_047293325.1  band 4.1-like protein 3 isoform X12

    19. XM_047437373.1 → XP_047293329.1  band 4.1-like protein 3 isoform X16

    20. XM_047437374.1 → XP_047293330.1  band 4.1-like protein 3 isoform X19

    21. XM_047437376.1 → XP_047293332.1  band 4.1-like protein 3 isoform X22

    22. XM_047437377.1 → XP_047293333.1  band 4.1-like protein 3 isoform X24

    23. XM_047437375.1 → XP_047293331.1  band 4.1-like protein 3 isoform X20

    24. XM_017025620.3 → XP_016881109.1  band 4.1-like protein 3 isoform X18

      UniProtKB/TrEMBL
      B3KY28

    25. XM_047437371.1 → XP_047293327.1  band 4.1-like protein 3 isoform X14

    26. XM_047437365.1 → XP_047293321.1  band 4.1-like protein 3 isoform X8

    27. XM_047437359.1 → XP_047293315.1  band 4.1-like protein 3 isoform X2

    28. XM_047437363.1 → XP_047293319.1  band 4.1-like protein 3 isoform X6

    29. XM_047437360.1 → XP_047293316.1  band 4.1-like protein 3 isoform X3

    30. XM_047437358.1 → XP_047293314.1  band 4.1-like protein 3 isoform X1

    31. XM_047437362.1 → XP_047293318.1  band 4.1-like protein 3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      5552548..5790830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318335.1 → XP_054174310.1  band 4.1-like protein 3 isoform X31

    2. XM_054318319.1 → XP_054174294.1  band 4.1-like protein 3 isoform X15

    3. XM_054318333.1 → XP_054174308.1  band 4.1-like protein 3 isoform X29

    4. XM_054318334.1 → XP_054174309.1  band 4.1-like protein 3 isoform X30

    5. XM_054318332.1 → XP_054174307.1  band 4.1-like protein 3 isoform X28

    6. XM_054318329.1 → XP_054174304.1  band 4.1-like protein 3 isoform X25

    7. XM_054318331.1 → XP_054174306.1  band 4.1-like protein 3 isoform X27

    8. XM_054318327.1 → XP_054174302.1  band 4.1-like protein 3 isoform X23

    9. XM_054318325.1 → XP_054174300.1  band 4.1-like protein 3 isoform X21

    10. XM_054318321.1 → XP_054174296.1  band 4.1-like protein 3 isoform X17

    11. XM_054318315.1 → XP_054174290.1  band 4.1-like protein 3 isoform X11

    12. XM_054318311.1 → XP_054174286.1  band 4.1-like protein 3 isoform X7

    13. XM_054318314.1 → XP_054174289.1  band 4.1-like protein 3 isoform X10

    14. XM_054318313.1 → XP_054174288.1  band 4.1-like protein 3 isoform X9

    15. XM_054318308.1 → XP_054174283.1  band 4.1-like protein 3 isoform X4

    16. XM_054318317.1 → XP_054174292.1  band 4.1-like protein 3 isoform X13

    17. XM_054318330.1 → XP_054174305.1  band 4.1-like protein 3 isoform X26

    18. XM_054318316.1 → XP_054174291.1  band 4.1-like protein 3 isoform X12

    19. XM_054318320.1 → XP_054174295.1  band 4.1-like protein 3 isoform X16

    20. XM_054318323.1 → XP_054174298.1  band 4.1-like protein 3 isoform X19

    21. XM_054318326.1 → XP_054174301.1  band 4.1-like protein 3 isoform X22

    22. XM_054318328.1 → XP_054174303.1  band 4.1-like protein 3 isoform X24

    23. XM_054318324.1 → XP_054174299.1  band 4.1-like protein 3 isoform X20

    24. XM_054318322.1 → XP_054174297.1  band 4.1-like protein 3 isoform X18

    25. XM_054318318.1 → XP_054174293.1  band 4.1-like protein 3 isoform X14

    26. XM_054318312.1 → XP_054174287.1  band 4.1-like protein 3 isoform X8

    27. XM_054318306.1 → XP_054174281.1  band 4.1-like protein 3 isoform X2

    28. XM_054318310.1 → XP_054174285.1  band 4.1-like protein 3 isoform X6

    29. XM_054318307.1 → XP_054174282.1  band 4.1-like protein 3 isoform X3

    30. XM_054318305.1 → XP_054174280.1  band 4.1-like protein 3 isoform X1

    31. XM_054318309.1 → XP_054174284.1  band 4.1-like protein 3 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2J2.2 GenPept UniProtKB/Swiss-Prot:Q9Y2J2

    Gene LinkOut

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