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    TRAK2 trafficking kinesin protein 2 [ Homo sapiens (human) ]

    Gene ID: 66008, updated on 4-Jan-2025

    Summary

    Official Symbol
    TRAK2provided by HGNC
    Official Full Name
    trafficking kinesin protein 2provided by HGNC
    Primary source
    HGNC:HGNC:13206
    See related
    Ensembl:ENSG00000115993 MIM:607334; AllianceGenome:HGNC:13206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRIF1; MILT2; OIP98; CALS-C; GRIF-1; ALS2CR3
    Summary
    Predicted to enable GABA receptor binding activity and myosin binding activity. Predicted to be involved in several processes, including mitochondrion distribution; organelle transport along microtubule; and protein O-linked glycosylation. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in heart (RPKM 26.1), thyroid (RPKM 23.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TRAK2 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (201377207..201451458, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201857884..201933333, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202241930..202316181, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16986 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:202122995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16989 Neighboring gene caspase 8 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:202153225 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202184683-202185184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202185185-202185684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202289002-202289502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202289503-202290003 Neighboring gene SCYL2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:202315536-202316390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12232 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:202329405-202329904 Neighboring gene STE20 related adaptor beta Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:202348230-202348988 Neighboring gene uncharacterized LOC124906113 Neighboring gene C2 calcium dependent domain containing 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • KIAA0549

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GABA receptor binding  
    enables GABA receptor binding PubMed 
    enables myosin binding  
    enables protein binding PubMed 
    enables signaling receptor binding PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport of mitochondrion  
    involved_in mitochondrion distribution  
    involved_in neurogenesis  
    involved_in protein targeting  
    involved_in vesicle transport along microtubule  
    Component Evidence Code Pubs
    located_in axon cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytoplasmic vesicle  
    located_in cytosol  
    is_active_in dendrite  
    located_in early endosome  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    trafficking kinesin-binding protein 2
    Names
    O-linked N-acetylglucosamine transferase interacting protein 98
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein
    gamma-aminobutyric acid(A) receptor-interacting factor
    milton homolog 2
    trafficking protein, kinesin binding 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015049.3 → NP_055864.2  trafficking kinesin-binding protein 2

      See identical proteins and their annotated locations for NP_055864.2

      Status: VALIDATED

      Source sequence(s)
      AB011121, AB038951, AC007256, CA396280, DA314514, DA414989, DA575492
      Consensus CDS
      CCDS2347.1
      UniProtKB/Swiss-Prot
      E7EV21, O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6
      UniProtKB/TrEMBL
      Q8IU62
      Related
      ENSP00000328875.3, ENST00000332624.8
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:427 → 567
      Milton; Kinesin associated protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      201377207..201451458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445578.1 → XP_047301534.1  trafficking kinesin-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      E7EV21, O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6
      UniProtKB/TrEMBL
      Q8IU62
    2. XM_047445579.1 → XP_047301535.1  trafficking kinesin-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      Q86TA0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      201857884..201933333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343511.1 → XP_054199486.1  trafficking kinesin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q8IU62
    2. XM_054343508.1 → XP_054199483.1  trafficking kinesin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q8IU62
    3. XM_054343510.1 → XP_054199485.1  trafficking kinesin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q8IU62
    4. XM_054343509.1 → XP_054199484.1  trafficking kinesin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q8IU62
    5. XM_054343512.1 → XP_054199487.1  trafficking kinesin-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      Q86TA0
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