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    FAM76B family with sequence similarity 76 member B [ Homo sapiens (human) ]

    Gene ID: 143684, updated on 27-Dec-2024

    Summary

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    Official Symbol
    FAM76Bprovided by HGNC
    Official Full Name
    family with sequence similarity 76 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:28492
    See related
    Ensembl:ENSG00000077458 AllianceGenome:HGNC:28492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in several processes, including mRNA stabilization; negative regulation of macrophage activation; and negative regulation of protein export from nucleus. Located in nuclear speck. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.3), lymph node (RPKM 9.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FAM76B in Genome Data Viewer
    Location:
    11q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (95768953..95789782, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (95776343..95797175, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (95502117..95522946, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984377 Neighboring gene fibroblast growth factor receptor 3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5417 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:95523907-95524570 Neighboring gene centrosomal protein 57 Neighboring gene RNA, 5S ribosomal pseudogene 345 Neighboring gene myotubularin related protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B. Zheng X, et al. PLoS One, 2016. PMID 27018871, Free PMC Article
    2. FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA. Wang J, et al. Cell Mol Life Sci, 2024 Feb 29. PMID 38421448, Free PMC Article
    3. FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1. Wang D, et al. Elife, 2023 Aug 10. PMID 37643469, Free PMC Article
    4. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. Salichs E, et al. PLoS Genet, 2009 Mar. PMID 19266028, Free PMC Article
    5. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. Vasilescu J, et al. J Proteome Res, 2007 Jan. PMID 17203973

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
      Title: FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
    2. FAM76B regulates NF-kappaB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1.
      Title: FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of family with sequence similarity 76, member B (FAM76B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33371

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM76B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330357.2 → NP_001317286.1  protein FAM76B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI913200, AP001877, AW118814, BG718983, CN360040
      Consensus CDS
      CCDS81619.1
      UniProtKB/TrEMBL
      F5GX09
      Related
      ENSP00000441168.1, ENST00000536839.1
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 327
      FAM76; FAM76 protein

    2. NM_144664.5 → NP_653265.3  protein FAM76B isoform 1

      See identical proteins and their annotated locations for NP_653265.3

      Status: VALIDATED

      Source sequence(s)
      AP001877, AW118814, BG718983, BX647586
      Consensus CDS
      CCDS41700.1
      UniProtKB/Swiss-Prot
      B2R9C2, Q5HYJ3, Q6PIU3, Q8TC53
      Related
      ENSP00000351631.5, ENST00000358780.10
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 328
      FAM76; FAM76 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      95768953..95789782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426410.1 → XP_047282366.1  protein FAM76B isoform X1

    2. XM_011542610.3 → XP_011540912.1  protein FAM76B isoform X1

      See identical proteins and their annotated locations for XP_011540912.1

      Conserved Domains (1) summary
      pfam16046
      Location:4 → 302
      FAM76; FAM76 protein

    3. XM_047426411.1 → XP_047282367.1  protein FAM76B isoform X2

    4. XM_005273776.5 → XP_005273833.1  protein FAM76B isoform X1

      See identical proteins and their annotated locations for XP_005273833.1

      Conserved Domains (1) summary
      pfam16046
      Location:4 → 302
      FAM76; FAM76 protein

    5. XM_011542612.2 → XP_011540914.1  protein FAM76B isoform X3

      See identical proteins and their annotated locations for XP_011540914.1

      Conserved Domains (1) summary
      pfam16046
      Location:101 → 239
      FAM76; FAM76 protein

    6. XM_047426413.1 → XP_047282369.1  protein FAM76B isoform X4

    7. XM_047426412.1 → XP_047282368.1  protein FAM76B isoform X4

      Related
      ENSP00000444087.1, ENST00000543641.5

    8. XM_047426414.1 → XP_047282370.1  protein FAM76B isoform X5

    RNA

    1. XR_007062451.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      95776343..95797175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367748.1 → XP_054223723.1  protein FAM76B isoform X1

    2. XM_054367747.1 → XP_054223722.1  protein FAM76B isoform X1

    3. XM_054367749.1 → XP_054223724.1  protein FAM76B isoform X2

    4. XM_054367750.1 → XP_054223725.1  protein FAM76B isoform X3

    5. XM_054367752.1 → XP_054223727.1  protein FAM76B isoform X4

    6. XM_054367751.1 → XP_054223726.1  protein FAM76B isoform X4

    7. XM_054367753.1 → XP_054223728.1  protein FAM76B isoform X5

    RNA

    1. XR_008488343.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HYJ3.3 GenPept UniProtKB/Swiss-Prot:Q5HYJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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