Map1s microtubule-associated protein 1S [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map1sprovided by MGI
Official Full Name: microtubule-associated protein 1Sprovided by MGI
Primary source: MGI:MGI:2443304
See related: Ensembl:ENSMUSG00000019261 AllianceGenome:MGI:2443304
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Map8; Mtap1s; Bpy2ip1; VCY2IP1; 6430517J16Rik
Summary: Enables actin filament binding activity; identical protein binding activity; and microtubule binding activity. Involved in brain development. Acts upstream of or within microtubule cytoskeleton organization. Located in dendrite; microtubule cytoskeleton; and neuronal cell body. Is expressed in brain and spinal cord. Orthologous to human MAP1S (microtubule associated protein 1S). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 49.3), adrenal adult (RPKM 41.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.41 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71358618..71370173)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70905974..70917529)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S.
Title: Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S.
Depletion of MAP1S in mice leads to an accumulation of fibrosis-related proteins and the development of renal fibrosis in aged mice.
Title: Defects in MAP1S-mediated autophagy turnover of fibronectin cause renal fibrosis.
MAP1S-mediated autophagy plays an important role in maintaining mouse lifespan especially in the presence of extra amount of fibronectin.
Title: Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed.
Data (including data from studies in knockout mice) suggest that Map1s interacts directly with MyD88 (myeloid differentiation primary response gene 88), a key adaptor of Toll-like receptors, as phagocytosis of bacteria is initiated in macrophages.
Title: MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like Receptor (TLR) Signaling.
Data establish a link between MAP1S-enhanced autophagy and suppression of genomic instability and tumorigenesis.
Title: Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis.
clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance.
Title: Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.
MAP8 is a novel microtubule associated protein containing two microtubule binding domains.
Title: Microtubule-associated protein 8 contains two microtubule binding sites.
Axonal transport impairment may be a deleterious consequence of accumulated, toxic MAP8 protein.
Title: Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in metaphase chromosome alignment	IEA Inferred from Electronic Annotation more info
involved_in metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring at centrosome	IEA Inferred from Electronic Annotation more info
involved_in microtubule anchoring at centrosome	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle microtubule	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle microtubule	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in spindle	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microtubule-associated protein 1S

Names: BPY2 interacting protein 1; MAP-1S; microtubule-associated protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173013.3 → NP_766601.2 microtubule-associated protein 1S

See identical proteins and their annotated locations for NP_766601.2

Status: VALIDATED

Source sequence(s)

AA048974, AK032300, AK162124, BB857804

Consensus CDS

CCDS22387.1

UniProtKB/Swiss-Prot

E9QKR8, Q3TSD6, Q7TMW8, Q8C052

UniProtKB/TrEMBL

B2RWW1

Related

ENSMUSP00000019405.3, ENSMUST00000019405.4

Conserved Domains (1) summary

PHA03307
Location:448 → 855

PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71358618..71370173

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154077.1 → XP_036009970.1 microtubule-associated protein 1S isoform X2

UniProtKB/TrEMBL

B2RWW1

Conserved Domains (1) summary

PHA03307
Location:339 → 746

PHA03307; transcriptional regulator ICP4; Provisional
XM_011242305.2 → XP_011240607.1 microtubule-associated protein 1S isoform X1

UniProtKB/TrEMBL

B2RWW1

Conserved Domains (1) summary

PHA03307
Location:366 → 773

PHA03307; transcriptional regulator ICP4; Provisional