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    Hook2 hook microtubule tethering protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 170833, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hook2provided by MGI
    Official Full Name
    hook microtubule tethering protein 2provided by MGI
    Primary source
    MGI:MGI:2181664
    See related
    Ensembl:ENSMUSG00000052566 AllianceGenome:MGI:2181664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mHK2; A630054I03Rik
    Summary
    Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be located in cytosol and trans-Golgi network. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Orthologous to human HOOK2 (hook microtubule tethering protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 21.0), testis adult (RPKM 20.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hook2 in Genome Data Viewer
    Location:
    8 C3; 8 41.44 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85715402..85729981)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84988776..85003352)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 2 Neighboring gene STARR-seq mESC enhancer starr_22143 Neighboring gene STARR-positive B cell enhancer ABC_E1764 Neighboring gene STARR-positive B cell enhancer ABC_E706 Neighboring gene jun B proto-oncogene Neighboring gene STARR-positive B cell enhancer ABC_E5029 Neighboring gene STARR-positive B cell enhancer ABC_E3789 Neighboring gene bestrophin 2 Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome. Moynihan KL, et al. Mol Biol Cell, 2009 Nov. PMID 19793914, Free PMC Article
    2. LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility. Liu Y, et al. PLoS Genet, 2015 Mar. PMID 25781171, Free PMC Article
    3. Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). White RA, et al. Blood Cells Mol Dis, 2009 Sep-Oct. PMID 19409822
    4. Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Quesnel-Vallières M, et al. Genes Dev, 2015 Apr 1. PMID 25838543, Free PMC Article
    5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28586, MGC91008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in early endosome to late endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FHF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of HOPS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein Hook homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167991.3 → NP_001161463.1  protein Hook homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001161463.1

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3TKK8, Q3UWV9
      Conserved Domains (2) summary
      pfam05622
      Location:8 → 703
      HOOK; HOOK protein
      pfam10267
      Location:260 → 344
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. NM_001363497.2 → NP_001350426.1  protein Hook homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:8 → 707
      HOOK; HOOK protein

    3. NM_001363498.2 → NP_001350427.1  protein Hook homolog 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163703
      Consensus CDS
      CCDS90430.1
      UniProtKB/TrEMBL
      A0A1B0GT78, Q3UWV9
      Related
      ENSMUSP00000148237.2, ENSMUST00000209764.2
      Conserved Domains (1) summary
      pfam05622
      Location:8 → 680
      HOOK; HOOK protein

    4. NM_001372357.1 → NP_001359286.1  protein Hook homolog 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:8 → 770
      HOOK; HOOK protein

    5. NM_001372358.1 → NP_001359287.1  protein Hook homolog 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:8 → 701
      HOOK; HOOK protein

    6. NM_001372359.1 → NP_001359288.1  protein Hook homolog 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:8 → 700
      HOOK; HOOK protein

    7. NM_001372360.1 → NP_001359289.1  protein Hook homolog 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:8 → 691
      HOOK; HOOK protein

    8. NM_001372361.1 → NP_001359290.1  protein Hook homolog 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:60 → 634
      HOOK; HOOK protein

    9. NM_001372362.1 → NP_001359291.1  protein Hook homolog 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:1 → 569
      HOOK; HOOK protein

    10. NM_133255.4 → NP_573518.2  protein Hook homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_573518.2

      Status: VALIDATED

      Source sequence(s)
      AC163703
      Consensus CDS
      CCDS22489.1
      UniProtKB/Swiss-Prot
      Q66JV2, Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2
      UniProtKB/TrEMBL
      Q3UWV9
      Related
      ENSMUSP00000067752.7, ENSMUST00000064495.8
      Conserved Domains (2) summary
      pfam05622
      Location:8 → 704
      HOOK; HOOK protein
      pfam10267
      Location:260 → 344
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RNA

    1. NR_156707.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163703

    2. NR_164168.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163703

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85715402..85729981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243323.2 → XP_030099183.1  protein Hook homolog 2 isoform X6

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:1 → 635
      HOOK; HOOK protein

    2. XM_030243325.2 → XP_030099185.1  protein Hook homolog 2 isoform X6

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:1 → 635
      HOOK; HOOK protein

    3. XM_036153782.1 → XP_036009675.1  protein Hook homolog 2 isoform X5

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (2) summary
      pfam05622
      Location:66 → 655
      HOOK; HOOK protein
      pfam19047
      Location:16 → 44
      HOOK_N; HOOK domain

    4. XM_036153778.1 → XP_036009671.1  protein Hook homolog 2 isoform X1

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (2) summary
      pfam05622
      Location:179 → 767
      HOOK; HOOK protein
      pfam19047
      Location:7 → 157
      HOOK_N; HOOK domain

    5. XM_036153780.1 → XP_036009673.1  protein Hook homolog 2 isoform X3

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (2) summary
      pfam05622
      Location:179 → 704
      HOOK; HOOK protein
      cl41774
      Location:7 → 156
      HkD_SF; Hook domain-containing proteins superfamily

    6. XM_036153781.1 → XP_036009674.1  protein Hook homolog 2 isoform X4

      Conserved Domains (2) summary
      pfam05622
      Location:110 → 699
      HOOK; HOOK protein
      pfam19047
      Location:60 → 88
      HOOK_N; HOOK domain

    7. XM_036153779.1 → XP_036009672.1  protein Hook homolog 2 isoform X2

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (2) summary
      pfam05622
      Location:230 → 819
      HOOK; HOOK protein
      pfam19047
      Location:67 → 208
      HOOK_N; HOOK domain

    8. XM_030243326.2 → XP_030099186.1  protein Hook homolog 2 isoform X6

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:1 → 635
      HOOK; HOOK protein

    9. XM_030243322.1 → XP_030099182.1  protein Hook homolog 2 isoform X6

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:1 → 635
      HOOK; HOOK protein

    10. XM_030243324.1 → XP_030099184.1  protein Hook homolog 2 isoform X6

      UniProtKB/TrEMBL
      Q3UWV9
      Conserved Domains (1) summary
      pfam05622
      Location:1 → 635
      HOOK; HOOK protein

    11. XM_030243328.2 → XP_030099188.1  protein Hook homolog 2 isoform X7

      Conserved Domains (1) summary
      pfam05622
      Location:1 → 390
      HOOK; HOOK protein

    RNA

    1. XR_004934775.1 RNA Sequence

    2. XR_004934776.1 RNA Sequence

    3. XR_004934778.1 RNA Sequence

    4. XR_004934773.1 RNA Sequence

    5. XR_004934774.1 RNA Sequence

    6. XR_004934777.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMK6.3 GenPept UniProtKB/Swiss-Prot:Q7TMK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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