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    Pramel1 PRAME like 1 [ Mus musculus (house mouse) ]

    Gene ID: 83491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pramel1provided by MGI
    Official Full Name
    PRAME like 1provided by MGI
    Primary source
    MGI:MGI:1890541
    See related
    Ensembl:ENSMUSG00000041805 AllianceGenome:MGI:1890541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 4.4) See more
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    Genomic context

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    See Pramel1 in Genome Data Viewer
    Location:
    4 E1; 4 77.64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (143120889..143126730)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (143394441..143399819)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 38 Neighboring gene Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_11972 Neighboring gene PRAME like 12 Neighboring gene oogenesin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis. Yang M, et al. Development, 2023 Nov 1. PMID 37781892
    2. Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse. Mistry BV, et al. PLoS One, 2013. PMID 23565261, Free PMC Article
    3. Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte. Dadé S, et al. FEBS Lett, 2003 Dec 18. PMID 14675769
    4. An abundance of X-linked genes expressed in spermatogonia. Wang PJ, et al. Nat Genet, 2001 Apr. PMID 11279525
    5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.
      Title: Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    preferentially expressed antigen in melanoma-like protein 1
    Names
    preferentially expressed antigen in melanoma-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031377.2 → NP_113554.1  preferentially expressed antigen in melanoma-like protein 1

      See identical proteins and their annotated locations for NP_113554.1

      Status: VALIDATED

      Source sequence(s)
      AL611930
      Consensus CDS
      CCDS18888.1
      UniProtKB/Swiss-Prot
      Q99MW3
      Related
      ENSMUSP00000043718.4, ENSMUST00000037419.4
      Conserved Domains (1) summary
      sd00034
      Location:293 → 319
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      143120889..143126730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164575.1 → XP_036020468.1  preferentially expressed antigen in melanoma-like protein 1 isoform X1

      Conserved Domains (2) summary
      sd00033
      Location:230 → 255
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:227 → 360
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MW3.1 GenPept UniProtKB/Swiss-Prot:Q99MW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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