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    Tmsb10 thymosin beta 10 [ Mus musculus (house mouse) ]

    Gene ID: 19240, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmsb10provided by MGI
    Official Full Name
    thymosin beta 10provided by MGI
    Primary source
    MGI:MGI:109146
    See related
    Ensembl:ENSMUSG00000079523 AllianceGenome:MGI:109146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tb10; Ptmb10
    Summary
    Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration and sequestering of actin monomers. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human TMSB10 (thymosin beta 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 401.3), CNS E14 (RPKM 333.4) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmsb10 in Genome Data Viewer
    Location:
    6 C1; 6 32.35 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72934330..72935731, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72957347..72958748, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16319 Neighboring gene STARR-seq mESC enhancer starr_16322 Neighboring gene potassium channel modulatory factor 1 Neighboring gene STARR-seq mESC enhancer starr_16325 Neighboring gene STARR-seq mESC enhancer starr_16327 Neighboring gene STARR-seq mESC enhancer starr_16328 Neighboring gene nuclear encoded tRNA serine 9 (anticodon GCT) Neighboring gene STARR-seq mESC enhancer starr_16329 Neighboring gene mediator complex subunit 29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16330 Neighboring gene predicted gene, 31547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Quantitative analysis of thymosin beta-10 messenger RNA in thyroid carcinomas. Takano T, et al. Jpn J Clin Oncol, 2002 Jul. PMID 12324571
    2. The beta-thymosins, small actin-binding peptides widely expressed in the developing and adult cerebellum. Gómez-Márquez J, et al. Cerebellum, 2002 Apr. PMID 12882358
    3. Thymosin beta10 mRNA expression during early postimplantation mouse development. Carpintero P, et al. FEBS Lett, 1996 Sep 23. PMID 8925915
    4. Upregulation of thymosin beta-10 by Mycobacterium bovis infection of bovine macrophages is associated with apoptosis. Gutiérrez-Pabello JA, et al. Infect Immun, 2002 Apr. PMID 11895978, Free PMC Article
    5. The expression and function of thymosin beta 10 in tooth germ development. Shiotsuka M, et al. Int J Dev Biol, 2013. PMID 24623079

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tbeta10 has multiple functions in the developmental course from initiation to root formation of the tooth germ
      Title: The expression and function of thymosin beta 10 in tooth germ development.
    2. We found an increased expression of thymosin beta-10 mRNA in thyroid carcinomas, especially in anaplastic carcinomas.
      Title: Quantitative analysis of thymosin beta-10 messenger RNA in thyroid carcinomas.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thymosin beta-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039392.3 → NP_001034481.1  thymosin beta-10

      See identical proteins and their annotated locations for NP_001034481.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC153842
      Consensus CDS
      CCDS39519.1
      UniProtKB/Swiss-Prot
      Q3V2M3, Q6ZWY8
      UniProtKB/TrEMBL
      A6H6H4, J3QK33
      Related
      ENSMUSP00000109683.2, ENSMUST00000114049.2
      Conserved Domains (1) summary
      pfam01290
      Location:3 → 41
      Thymosin; Thymosin beta-4 family

    2. NM_001190327.1 → NP_001177256.1  thymosin beta-10

      See identical proteins and their annotated locations for NP_001177256.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC153842, AK003178
      Consensus CDS
      CCDS39519.1
      UniProtKB/Swiss-Prot
      Q3V2M3, Q6ZWY8
      UniProtKB/TrEMBL
      A6H6H4, J3QK33
      Related
      ENSMUSP00000109682.2, ENSMUST00000114048.2
      Conserved Domains (1) summary
      pfam01290
      Location:3 → 41
      Thymosin; Thymosin beta-4 family

    3. NM_025284.5 → NP_079560.1  thymosin beta-10

      See identical proteins and their annotated locations for NP_079560.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC153842
      Consensus CDS
      CCDS39519.1
      UniProtKB/Swiss-Prot
      Q3V2M3, Q6ZWY8
      UniProtKB/TrEMBL
      A6H6H4, J3QK33
      Related
      ENSMUSP00000109684.2, ENSMUST00000114050.8
      Conserved Domains (1) summary
      pfam01290
      Location:3 → 41
      Thymosin; Thymosin beta-4 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72934330..72935731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWY8.3 GenPept UniProtKB/Swiss-Prot:Q6ZWY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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