Cacnb3 calcium channel, voltage-dependent, beta 3 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacnb3provided by MGI
Official Full Name: calcium channel, voltage-dependent, beta 3 subunitprovided by MGI
Primary source: MGI:MGI:103307
See related: Ensembl:ENSMUSG00000003352 AllianceGenome:MGI:103307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAB3; Beta3; Cchb3; Ca(v)beta3
Summary: Predicted to enable calcium channel regulator activity; high voltage-gated calcium channel activity; and protein kinase binding activity. Acts upstream of or within T cell receptor signaling pathway. Part of voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in frontal lobe adult (RPKM 57.2), CNS E18 (RPKM 51.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.64 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98526317..98542410)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98628436..98644536)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cavbeta3 Contributes to the Maintenance of the Blood-Brain Barrier and Alleviates Symptoms of Experimental Autoimmune Encephalomyelitis.
Title: Cavβ3 Contributes to the Maintenance of the Blood-Brain Barrier and Alleviates Symptoms of Experimental Autoimmune Encephalomyelitis.
our results indicate that beta3, unrelated to its role as a Ca2+ channel subunit, specifically modulates the cell's IP3 sensitivity and thereby efficiently tunes agonist-induced cytoplasmic Ca2+ signals and cellular functions.
Title: IP(3) Receptor-Dependent Cytoplasmic Ca(2+) Signals Are Tightly Controlled by Cavβ3.
During development Cavbeta3 protein expression in the cerebellum peaks at postnatal days 15 and 21, and has diminished drastically by day 60, and in the hippocampus increases with age throughout all subfields.
Title: Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
In transgenic mice lacking the calcium channel beta3 subunit, there are compensatory changes of calcium channel abundance leading to adaptation of alternate calcium transport mechanisms.
Title: Impaired renal calcium absorption in mice lacking calcium channel beta 3 subunits.
Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation
Title: Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation.
these results indicate the importance of the beta3 subunit in determining calcium channel characteristics and catecholamine release in adrenal chromaffin cells.
Title: Decreased calcium channel currents and facilitated epinephrine release in the Ca2+ channel beta3 subunit-null mice.
neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties
Title: Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4.
Deficiency in beta3 regulatory subunit of voltage-gated calcium channels resulted in a profound survival defect of CD8(+) T cells.
Title: Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.
These results suggest a possibility that, unrelated to voltage-dependent Ca(2+) channels regulation, Ca(v)beta3 negatively regulates the NMDAR activity in the hippocampus.
Title: Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory.
Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit.(
Title: Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cacnb3 (e-PCR), detects polymorphism
- UniSTS:141212

PMC21756P1 (e-PCR)
- UniSTS:272067

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables high voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of detection of mechanical stimulus involved in sensory perception of touch	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of high voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization during action potential	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of L-type voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of L-type voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent L-type calcium channel subunit beta-3

Names: calcium channel voltage-dependent subunit beta 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044741.3 → NP_001038206.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 2

Status: VALIDATED

Source sequence(s)

AC156543

Consensus CDS

CCDS37192.1

UniProtKB/TrEMBL

D3Z3Z3, Q8K5A7

Related

ENSMUSP00000104778.2, ENSMUST00000109150.9

Conserved Domains (4) summary

cd12042
Location:57 → 124

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:175 → 355

Guanylate_kin; Guanylate kinase

pfam12052
Location:15 → 57

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

cl17190
Location:185 → 356

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001286226.2 → NP_001273155.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 3

Status: VALIDATED

Source sequence(s)

AC156543

Consensus CDS

CCDS88834.1

UniProtKB/TrEMBL

A0A2U3TZ49, Q8K5A7

Related

ENSMUSP00000003442.9, ENSMUST00000003442.9

Conserved Domains (4) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:166 → 329

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

cl17190
Location:165 → 330

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001356543.2 → NP_001343472.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 4

Status: VALIDATED

Source sequence(s)

AC156543

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:57 → 124

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam12052
Location:15 → 57

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

cl27059
Location:174 → 354

Guanylate_kin; Guanylate kinase
NM_001410382.1 → NP_001397311.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 5

Status: VALIDATED

Source sequence(s)

AC156543

UniProtKB/TrEMBL

Q8K5A7
NM_001410383.1 → NP_001397312.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 6

Status: VALIDATED

Source sequence(s)

AC156543

UniProtKB/TrEMBL

Q8K5A7
NM_001410384.1 → NP_001397313.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 7

Status: VALIDATED

Source sequence(s)

AC156543

UniProtKB/TrEMBL

Q8K5A7
NM_007581.4 → NP_031607.2 voltage-dependent L-type calcium channel subunit beta-3 isoform 1

See identical proteins and their annotated locations for NP_031607.2

Status: VALIDATED

Source sequence(s)

AC156543

Consensus CDS

CCDS27800.1

UniProtKB/Swiss-Prot

G5E821, P54285

UniProtKB/TrEMBL

Q8K5A7

Related

ENSMUSP00000155514.2, ENSMUST00000230490.2

Conserved Domains (3) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:176 → 356

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

RNA

NR_177064.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC156543

Related

ENSMUST00000230064.2
NR_177065.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC156543

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

98526317..98542410

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316418.3 → XP_017171907.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X10

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:45 → 112

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:163 → 343

Guanylate_kin; Guanylate kinase

pfam12052
Location:3 → 45

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_006520365.2 → XP_006520428.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X10

See identical proteins and their annotated locations for XP_006520428.1

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:45 → 112

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:163 → 343

Guanylate_kin; Guanylate kinase

pfam12052
Location:3 → 45

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_036159101.1 → XP_036014994.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X12

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:45 → 112

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:163 → 343

Guanylate_kin; Guanylate kinase

pfam12052
Location:3 → 45

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_030248302.2 → XP_030104162.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X1

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:176 → 356

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_030248304.2 → XP_030104164.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X1

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:176 → 356

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_006520367.2 → XP_006520430.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X13

See identical proteins and their annotated locations for XP_006520430.1

Conserved Domains (1) summary

pfam00625
Location:1 → 180

Guanylate_kin; Guanylate kinase
XM_017316415.3 → XP_017171904.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X1

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:176 → 356

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_030248303.2 → XP_030104163.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X1

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:176 → 356

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_036159097.1 → XP_036014990.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X5

UniProtKB/Swiss-Prot

G5E821, P54285

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:176 → 356

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_030248306.2 → XP_030104166.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X13

Conserved Domains (1) summary

pfam00625
Location:1 → 180

Guanylate_kin; Guanylate kinase
XM_036159102.1 → XP_036014995.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X13

Conserved Domains (1) summary

pfam00625
Location:1 → 180

Guanylate_kin; Guanylate kinase
XM_036159104.1 → XP_036014997.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X14

Conserved Domains (1) summary

pfam00625
Location:1 → 180

Guanylate_kin; Guanylate kinase
XM_036159100.1 → XP_036014993.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X11

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:49 → 116

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:167 → 347

Guanylate_kin; Guanylate kinase

pfam12052
Location:7 → 49

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_006520361.4 → XP_006520424.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X3

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:175 → 355

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_006520363.4 → XP_006520426.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X6

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:52 → 119

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:170 → 350

Guanylate_kin; Guanylate kinase

pfam12052
Location:10 → 52

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_006520364.4 → XP_006520427.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X8

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:49 → 116

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:167 → 347

Guanylate_kin; Guanylate kinase

pfam12052
Location:7 → 49

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_036159106.1 → XP_036014999.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X15

Conserved Domains (1) summary

pfam00625
Location:1 → 111

Guanylate_kin; Guanylate kinase
XM_030248305.2 → XP_030104165.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X13

Conserved Domains (1) summary

pfam00625
Location:1 → 180

Guanylate_kin; Guanylate kinase
XM_036159103.1 → XP_036014996.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X14

Conserved Domains (1) summary

pfam00625
Location:1 → 180

Guanylate_kin; Guanylate kinase
XM_036159099.1 → XP_036014992.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X9

UniProtKB/TrEMBL

Q8K5A7

Conserved Domains (3) summary

cd12042
Location:52 → 119

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:170 → 350

Guanylate_kin; Guanylate kinase

pfam12052
Location:10 → 52

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal