Tekt1 tektin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tekt1provided by MGI
Official Full Name: tektin 1provided by MGI
Primary source: MGI:MGI:1333819
See related: Ensembl:ENSMUSG00000020799 AllianceGenome:MGI:1333819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MT14
Summary: Involved in flagellated sperm motility. Located in microtubule cytoskeleton. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in several structures, including brain; lung; sensory organ; and testis. Orthologous to human TEKT1 (tektin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 66.9) and lung adult (RPKM 2.4) See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 44.03 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72235543..72253268, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (72344717..72362442, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tnp1, Tekt1, and Plzf have essential roles in spermatogenesis and can be expressed during organ culture of testis; with this system, genes can be induced only at the molecular level and not beyond meiosis.
Title: Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro Three-Dimensional Neonatal Male Mice Testis Culture.
These observations suggest another potential role for TEKT1 as a cytoskeletal element in the sperm head, or as a molecule involved in acrosome-related phenomena, such as acrosome reaction.
Title: Localization of Tektin 1 at both acrosome and flagella of mouse and bull spermatozoa.
Tekt1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Tekt1 (e-PCR), detects polymorphism
- UniSTS:547540

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	IDA Inferred from Direct Assay more info	PubMed
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tektin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282006.1 → NP_001268935.1 tektin-1

See identical proteins and their annotated locations for NP_001268935.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AK005801, AV279795

Consensus CDS

CCDS36215.1

UniProtKB/Swiss-Prot

Q9DAJ2

UniProtKB/TrEMBL

Q5NBU4, Q9Z285

Related

ENSMUSP00000021155.4, ENSMUST00000021155.4

Conserved Domains (1) summary

pfam03148
Location:16 → 395

Tektin; Tektin family
NM_001282007.1 → NP_001268936.1 tektin-1

See identical proteins and their annotated locations for NP_001268936.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AV279795, BC050967

Consensus CDS

CCDS36215.1

UniProtKB/Swiss-Prot

Q9DAJ2

UniProtKB/TrEMBL

Q5NBU4, Q9Z285

Related

ENSMUSP00000104142.2, ENSMUST00000108502.8

Conserved Domains (1) summary

pfam03148
Location:16 → 395

Tektin; Tektin family
NM_011569.3 → NP_035699.2 tektin-1

See identical proteins and their annotated locations for NP_035699.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AV279795, BB572578, BC098181, BY085053

Consensus CDS

CCDS36215.1

UniProtKB/Swiss-Prot

Q9DAJ2

UniProtKB/TrEMBL

Q5NBU4, Q9Z285

Related

ENSMUSP00000104143.3, ENSMUST00000108503.9

Conserved Domains (1) summary

pfam03148
Location:16 → 395

Tektin; Tektin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

72235543..72253268 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532933.3 → XP_006532996.1 tektin-1 isoform X1

UniProtKB/TrEMBL

Q9Z285

Conserved Domains (1) summary

pfam03148
Location:19 → 349

Tektin; Tektin family