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    Sypl1 synaptophysin like 1 [ Mus musculus (house mouse) ]

    Gene ID: 19027, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sypl1provided by MGI
    Official Full Name
    synaptophysin like 1provided by MGI
    Primary source
    MGI:MGI:108081
    See related
    Ensembl:ENSMUSG00000020570 AllianceGenome:MGI:108081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PanI; Pphn; Sypl; D12Ertd446e
    Summary
    Located in membrane and secretory granule. Is expressed in neocortex. Orthologous to human SYPL1 (synaptophysin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.7), testis adult (RPKM 11.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sypl1 in Genome Data Viewer
    Location:
    12 A3; 12 13.87 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (33003874..33029503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (32953855..32979502)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406C10 gene Neighboring gene coiled-coil domain containing 69 pseudogene Neighboring gene predicted gene, 51998 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:33639684-33639867 Neighboring gene STARR-seq mESC enhancer starr_31885 Neighboring gene predicted gene, 40874 Neighboring gene predicted gene, 24922 Neighboring gene cadherin-related family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility. Liu J, et al. Nat Commun, 2023 Aug 22. PMID 37607933, Free PMC Article
    2. Nucleotide polymorphism and natural selection at the pantophysin (Pan I) locus in the Atlantic cod, Gadus morhua (L.). Pogson GH. Genetics, 2001 Jan. PMID 11139512, Free PMC Article
    3. Tissue expression of the vesicle protein pantophysin. Windoffer R, et al. Cell Tissue Res, 1999 Jun. PMID 10370136
    4. Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. Haass NK, et al. J Cell Biol, 1996 Aug. PMID 8707851, Free PMC Article
    5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility.
      Title: SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptophysin-like protein 1
    Names
    Pan I
    pantophysin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013635.3 → NP_038663.2  synaptophysin-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_038663.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC155258, BC060971
      Consensus CDS
      CCDS25872.1
      UniProtKB/Swiss-Prot
      O09117, Q8BQI8, Q8BQJ1, Q8C749
      UniProtKB/TrEMBL
      Q3U4T9
      Related
      ENSMUSP00000075990.6, ENSMUST00000076698.13
      Conserved Domains (1) summary
      pfam01284
      Location:110 → 233
      MARVEL; Membrane-associating domain

    2. NM_198710.3 → NP_942003.1  synaptophysin-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_942003.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment of the 5' UTR and 5' coding region, compared to variant 1. These differences result in a unique 5' UTR and a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC155258, AK049556, BB847647
      Consensus CDS
      CCDS25873.1
      UniProtKB/TrEMBL
      Q3TVX7, Q3U4T9
      Related
      ENSMUSP00000020885.7, ENSMUST00000020885.13
      Conserved Domains (1) summary
      pfam01284
      Location:92 → 215
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      33003874..33029503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243842.3 → XP_011242144.1  synaptophysin-like protein 1 isoform X1

    2. XM_011243843.3 → XP_011242145.1  synaptophysin-like protein 1 isoform X2

    3. XM_036157254.1 → XP_036013147.1  synaptophysin-like protein 1 isoform X3

      Conserved Domains (1) summary
      pfam01284
      Location:1 → 81
      MARVEL; Membrane-associating domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09117.2 GenPept UniProtKB/Swiss-Prot:O09117

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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