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    B3gat2 beta-1,3-glucuronyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 280645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B3gat2provided by MGI
    Official Full Name
    beta-1,3-glucuronyltransferase 2provided by MGI
    Primary source
    MGI:MGI:2389490
    See related
    Ensembl:ENSMUSG00000026156 AllianceGenome:MGI:2389490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glcats; GlcAT-S
    Summary
    Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Predicted to be involved in carbohydrate biosynthetic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Barrett's esophagus and schizophrenia. Orthologous to human B3GAT2 (beta-1,3-glucuronyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 17.5), testis adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B3gat2 in Genome Data Viewer
    Location:
    1 A5; 1 9.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (23801007..23886946)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (23761926..23847865)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_00435 Neighboring gene predicted gene 28822 Neighboring gene STARR-seq mESC enhancer starr_00436 Neighboring gene STARR-seq mESC enhancer starr_00437 Neighboring gene STARR-positive B cell enhancer ABC_E4306 Neighboring gene small ArfGAP 1 Neighboring gene STARR-positive B cell enhancer ABC_E981 Neighboring gene predicted gene 53062 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene family with sequence similarity 135, member A Neighboring gene STARR-seq mESC enhancer starr_00443 Neighboring gene predicted gene, 30756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope. Imiya K, et al. Gene, 2002 Aug 21. PMID 12383500
    2. A Sulfated Glycosaminoglycan Linkage Region is a Novel Type of Human Natural Killer-1 (HNK-1) Epitope Expressed on Aggrecan in Perineuronal Nets. Yabuno K, et al. PLoS One, 2015. PMID 26659409, Free PMC Article
    3. Cloning and expression of a novel galactoside beta1, 3-glucuronyltransferase involved in the biosynthesis of HNK-1 epitope. Shimoda Y, et al. J Biol Chem, 1999 Jun 11. PMID 10358066
    4. Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Inoue M, et al. Brain Res, 2007 Nov 7. PMID 17935701
    5. Molecular cloning and genomic analysis of mouse glucuronyltransferase involved in biosynthesis of the HNK-1 epitope. Yamamoto S, et al. J Biochem, 2002 Mar. PMID 11872162

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. moderate expression of GlcAT-S were seen in neuronal cells of several nuclei of limbic-related regions
      Title: Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1963

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
    Names
    UDP-glucuronosyltransferase-S
    glcAT-D
    glucuronosyltransferase S
    NP_742122.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172124.2 → NP_742122.2  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_742122.2

      Status: VALIDATED

      Source sequence(s)
      AK052640, BC058082
      Consensus CDS
      CCDS14850.1
      UniProtKB/Swiss-Prot
      P59270
      UniProtKB/TrEMBL
      Q5DTT7
      Related
      ENSMUSP00000066582.6, ENSMUST00000063663.6
      Conserved Domains (1) summary
      cd00218
      Location:81 → 306
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      23801007..23886946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59270.1 GenPept UniProtKB/Swiss-Prot:P59270

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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