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    Psg21 pregnancy-specific beta-1-glycoprotein 21 [ Mus musculus (house mouse) ]

    Gene ID: 72242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psg21provided by MGI
    Official Full Name
    pregnancy-specific beta-1-glycoprotein 21provided by MGI
    Primary source
    MGI:MGI:1891353
    See related
    Ensembl:ENSMUSG00000070796 AllianceGenome:MGI:1891353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cea8; 1600019C01Rik; 1600025N01Rik; 1600026N13Rik
    Summary
    Predicted to be involved in T cell activation and immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Is expressed in labyrinthine zone. Orthologous to human CEACAM4 (CEA cell adhesion molecule 4); CEACAM7 (CEA cell adhesion molecule 7); and PSG5 (pregnancy specific beta-1-glycoprotein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 259.7) See more
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    Genomic context

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    See Psg21 in Genome Data Viewer
    Location:
    7 A3; 7 9.21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18380579..18390650, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18646654..18656725, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pregnancy-specific beta-1-glycoprotein 23 Neighboring gene RNA (guanine-9-) methyltransferase domain containing 2 pseudogene Neighboring gene pregnancy-specific beta-1-glycoprotein 20 Neighboring gene STARR-seq mESC enhancer starr_18172 Neighboring gene STARR-seq mESC enhancer starr_18173 Neighboring gene pregnancy-specific beta-1-glycoprotein 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An abundant placental transcript containing an IAP-LTR is allelic to mouse pregnancy-specific glycoprotein 23 (Psg23): cloning and genetic analysis. Ball M, et al. Gene, 2004 Jan 21. PMID 14697515
    2. Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature. Wynne F, et al. Reproduction, 2006 Apr. PMID 16595723
    3. Transient reduction of placental angiogenesis in PAI-1-deficient mice. Labied S, et al. Physiol Genomics, 2011 Feb 24. PMID 21119013
    4. Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Tunster SJ, et al. Dis Model Mech, 2018 Nov 16. PMID 30158284, Free PMC Article
    5. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Tunster SJ, et al. Dev Biol, 2016 Jan 1. PMID 26476147, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy-specific glycoprotein 21
    Names
    pregnancy-specific glrcoprotein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027403.4 → NP_081679.2  pregnancy-specific glycoprotein 21 precursor

      See identical proteins and their annotated locations for NP_081679.2

      Status: VALIDATED

      Source sequence(s)
      AA023284, AK005492, AK131670, BY033222
      Consensus CDS
      CCDS20875.1
      UniProtKB/TrEMBL
      Q9DAV5, Q9R1F9
      Related
      ENSMUSP00000092387.5, ENSMUST00000094793.12
      Conserved Domains (3) summary
      cd05774
      Location:155 → 259
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00408
      Location:396 → 457
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:391 → 468
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18380579..18390650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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