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    Txnip thioredoxin interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 56338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Txnipprovided by MGI
    Official Full Name
    thioredoxin interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1889549
    See related
    Ensembl:ENSMUSG00000038393 AllianceGenome:MGI:1889549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    THIF; Tbp-2; VDUP1; Hyplip1; 1200008J08Rik
    Summary
    Enables enzyme inhibitor activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; platelet-derived growth factor receptor signaling pathway; and protein import into nucleus. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Reye syndrome and hepatocellular carcinoma. Orthologous to human TXNIP (thioredoxin interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 279.2), lung adult (RPKM 241.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Txnip in Genome Data Viewer
    Location:
    3 F2.1; 3 41.93 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96465273..96469173)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96557957..96561857)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08437 Neighboring gene predicted gene, 40100 Neighboring gene hemojuvelin BMP co-receptor Neighboring gene STARR-positive B cell enhancer mm9_chr3:96351291-96351592 Neighboring gene STARR-positive B cell enhancer ABC_E6082 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96361830-96361983 Neighboring gene STARR-seq mESC enhancer starr_08439 Neighboring gene predicted gene 15441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96368663-96368826 Neighboring gene STARR-seq mESC enhancer starr_08441 Neighboring gene STARR-positive B cell enhancer ABC_E6083 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G like Neighboring gene STARR-seq mESC enhancer starr_08442 Neighboring gene STARR-positive B cell enhancer ABC_E3451 Neighboring gene ankyrin repeat domain 34A Neighboring gene predicted gene, 52628

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa. Xue Y, et al. Elife, 2021 Apr 13. PMID 33847261, Free PMC Article
    2. VDUP1 exacerbates bacteremic shock in mice infected with Pseudomonas aeruginosa. Piao ZH, et al. Cell Immunol, 2012 Nov. PMID 23246829
    3. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Oslowski CM, et al. Cell Metab, 2012 Aug 8. PMID 22883234, Free PMC Article
    4. Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction. Deng W, et al. Endocrine, 2020 Dec. PMID 32892310
    5. The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion. Muri J, et al. Eur J Immunol, 2021 Jan. PMID 32902872

    See all (234) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress.
      Title: REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress.
    2. Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress.
      Title: Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress.
    3. piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
      Title: piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
    4. A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.
      Title: A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.
    5. Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model.
      Title: Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model.
    6. METTL3 Modulates TXNIP Expression to Affect the Activation of NLRP3 Inflammasome in Hepatic Cells Under Oxygen-Glucose Deprivation/Reperfusion Injury.
      Title: METTL3 Modulates TXNIP Expression to Affect the Activation of NLRP3 Inflammasome in Hepatic Cells Under Oxygen-Glucose Deprivation/Reperfusion Injury.
    7. Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation.
      Title: Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation.
    8. FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation.
      Title: FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation.
    9. Deficiency of thioredoxin-interacting protein results in age-related thrombocytopenia due to megakaryocyte oxidative stress.
      Title: Deficiency of thioredoxin-interacting protein results in age-related thrombocytopenia due to megakaryocyte oxidative stress.
    10. Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
      Title: Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (172)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin-interacting protein
    Names
    hyperlipidemia 1
    thioredoxin binding protein-2
    upregulated by 1,25-dihydroxyvitamin D-3
    vitamin D3 up-regulated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009935.2 → NP_001009935.1  thioredoxin-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001009935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122037
      Consensus CDS
      CCDS38555.1
      UniProtKB/Swiss-Prot
      Q8BG60, Q8BGQ0, Q8K2B2, Q9DC00, Q9EP90, Q9R115
      UniProtKB/TrEMBL
      Q91X82
      Related
      ENSMUSP00000102710.3, ENSMUST00000074519.13
      Conserved Domains (2) summary
      pfam02752
      Location:175 → 299
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:10 → 153
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. NM_023719.2 → NP_076208.2  thioredoxin-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_076208.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AK089403, AK171456
      Consensus CDS
      CCDS17640.1
      UniProtKB/TrEMBL
      Q91X82
      Related
      ENSMUSP00000041467.8, ENSMUST00000049093.8
      Conserved Domains (2) summary
      pfam02752
      Location:174 → 298
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:10 → 152
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96465273..96469173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG60.1 GenPept UniProtKB/Swiss-Prot:Q8BG60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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