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    Mcub mitochondrial calcium uniporter dominant negative beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 66815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcubprovided by MGI
    Official Full Name
    mitochondrial calcium uniporter dominant negative beta subunitprovided by MGI
    Primary source
    MGI:MGI:1914065
    See related
    Ensembl:ENSMUSG00000027994 AllianceGenome:MGI:1914065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc109b; 9030408N13Rik
    Summary
    Enables calcium channel inhibitor activity. Involved in several processes, including mitochondrial calcium ion transmembrane transport; negative regulation of calcium import into the mitochondrion; and positive regulation of skeletal muscle satellite cell differentiation. Located in membrane and mitochondrion. Part of calcium channel complex. Orthologous to human MCUB (mitochondrial calcium uniporter dominant negative subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 4.1), bladder adult (RPKM 3.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcub in Genome Data Viewer
    Location:
    3 G3; 3 59.56 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129708609..129763850, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129914960..129970211, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46825 Neighboring gene caspase 6 Neighboring gene predicted gene, 40150 Neighboring gene predicted gene, 40151 Neighboring gene SEC24 homolog B, COPII coat complex component Neighboring gene STARR-seq mESC enhancer starr_08982 Neighboring gene predicted gene 9396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis. Ghatge M, et al. J Thromb Haemost, 2023 Aug. PMID 37061131
    2. The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration. Feno S, et al. Sci Signal, 2021 Nov 2. PMID 34726954
    3. MCUb Induction Protects the Heart From Postischemic Remodeling. Huo J, et al. Circ Res, 2020 Jul 17. PMID 32299299, Free PMC Article
    4. Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling. Márkus NM, et al. PLoS One, 2016. PMID 26828201, Free PMC Article
    5. MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle. Huo J, et al. Cell Rep, 2023 Nov 28. PMID 37976157, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle.
      Title: MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle.
    2. Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis.
      Title: Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis.
    3. MCUb Induction Protects the Heart From Postischemic Remodeling.
      Title: MCUb Induction Protects the Heart From Postischemic Remodeling.
    4. MCUB-dependent changes in mitochondrial calcium uniporter stoichiometry are a prominent regulatory mechanism to modulate mitochondrial Ca(2+) uptake and cardiac myocyte cellular physiology.
      Title: MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.
    5. Functional characterization of the MCUb protein; shows that it inhibits mitochondrial calcium uptake
      Title: The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of calcium import into the mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of skeletal muscle satellite cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of uniplex complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of uniplex complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calcium uniporter regulatory subunit MCUb, mitochondrial
    Names
    coiled-coil domain containing 109B
    coiled-coil domain-containing protein 109B
    mitochondrial calcium uniporter regulatory subunit MCUb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293644.2 → NP_001280573.2  calcium uniporter regulatory subunit MCUb, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC118620
      Consensus CDS
      CCDS80021.1
      UniProtKB/TrEMBL
      D6RIL8
      Related
      ENSMUSP00000118170.3, ENSMUST00000153506.8

    2. NM_025779.4 → NP_080055.3  calcium uniporter regulatory subunit MCUb, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118620
      Consensus CDS
      CCDS17839.1
      UniProtKB/Swiss-Prot
      Q3U4A9, Q810S1, Q9CSE7, Q9D345
      UniProtKB/TrEMBL
      A0A9S4GQC1
      Related
      ENSMUSP00000029624.10, ENSMUST00000029624.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      129708609..129763850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240197.4 → XP_011238499.1  calcium uniporter regulatory subunit MCUb, mitochondrial isoform X5

    2. XM_006501900.3 → XP_006501963.1  calcium uniporter regulatory subunit MCUb, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q3U4A9, Q810S1, Q9CSE7, Q9D345
      Conserved Domains (1) summary
      pfam04678
      Location:112 → 279
      MCU; Mitochondrial calcium uniporter

    3. XM_006501901.5 → XP_006501964.1  calcium uniporter regulatory subunit MCUb, mitochondrial isoform X3

      UniProtKB/Swiss-Prot
      Q3U4A9, Q810S1, Q9CSE7, Q9D345
      Conserved Domains (1) summary
      pfam04678
      Location:72 → 274
      MCU; Mitochondrial calcium uniporter

    4. XM_036163230.1 → XP_036019123.1  calcium uniporter regulatory subunit MCUb, mitochondrial isoform X4

      Conserved Domains (1) summary
      pfam04678
      Location:17 → 217
      MCU; Mitochondrial calcium uniporter

    5. XM_036163229.1 → XP_036019122.1  calcium uniporter regulatory subunit MCUb, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3U4A9, Q810S1, Q9CSE7, Q9D345
      Conserved Domains (1) summary
      pfam04678
      Location:102 → 304
      MCU; Mitochondrial calcium uniporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810S1.1 GenPept UniProtKB/Swiss-Prot:Q810S1

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