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    Apobr apolipoprotein B receptor [ Mus musculus (house mouse) ]

    Gene ID: 171504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Apobrprovided by MGI
    Official Full Name
    apolipoprotein B receptorprovided by MGI
    Primary source
    MGI:MGI:2176230
    See related
    Ensembl:ENSMUSG00000042759 AllianceGenome:MGI:2176230
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apob48r; Apob-48r
    Summary
    Enables very-low-density lipoprotein particle receptor activity. Acts upstream of or within triglyceride metabolic process. Predicted to be located in plasma membrane. Predicted to be part of chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Orthologous to human APOBR (apolipoprotein B receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 11.1), genital fat pad adult (RPKM 7.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apobr in Genome Data Viewer
    Location:
    7 F3; 7 69.17 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126184092..126188297)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126584918..126589125)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25579 Neighboring gene CLN3 lysosomal/endosomal transmembrane protein, battenin Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133726956-133727139 Neighboring gene microRNA 7059 Neighboring gene interleukin 27 Neighboring gene predicted gene, 39086 Neighboring gene predicted gene, 39087 Neighboring gene nuclear protein transcription regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor. Brown ML, et al. J Lipid Res, 2002 Aug. PMID 12177162
    2. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables very-low-density lipoprotein particle receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables very-low-density lipoprotein particle receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within triglyceride metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chylomicron IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein B receptor
    Names
    apolipoprotein B-100 receptor
    apolipoprotein B-48 receptor
    apolipoprotein B48 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138310.1 → NP_612183.1  apolipoprotein B receptor

      See identical proteins and their annotated locations for NP_612183.1

      Status: PROVISIONAL

      Source sequence(s)
      AF141335
      Consensus CDS
      CCDS21834.1
      UniProtKB/Swiss-Prot
      Q8VBT6
      Related
      ENSMUSP00000042028.7, ENSMUST00000039522.8
      Conserved Domains (2) summary
      PTZ00121
      Location:32 → 475
      PTZ00121; MAEBL; Provisional
      TIGR00927
      Location:503 → 804
      2A1904; K+-dependent Na+/Ca+ exchanger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126184092..126188297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152727.1 → XP_036008620.1  apolipoprotein B receptor isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:32 → 475
      PTZ00121; MAEBL; Provisional
      TIGR00927
      Location:503 → 804
      2A1904; K+-dependent Na+/Ca+ exchanger

    2. XM_006507399.5 → XP_006507462.1  apolipoprotein B receptor isoform X3

      Conserved Domains (1) summary
      PTZ00121
      Location:32 → 475
      PTZ00121; MAEBL; Provisional

    3. XM_036152728.1 → XP_036008621.1  apolipoprotein B receptor isoform X2

      Conserved Domains (1) summary
      PTZ00121
      Location:32 → 475
      PTZ00121; MAEBL; Provisional

    4. XM_036152729.1 → XP_036008622.1  apolipoprotein B receptor isoform X4

    5. XM_036152730.1 → XP_036008623.1  apolipoprotein B receptor isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBT6.1 GenPept UniProtKB/Swiss-Prot:Q8VBT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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