Csf1 colony stimulating factor 1 (macrophage) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csf1provided by MGI
Official Full Name: colony stimulating factor 1 (macrophage)provided by MGI
Primary source: MGI:MGI:1339753
See related: Ensembl:ENSMUSG00000014599 AllianceGenome:MGI:1339753
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: op; Csfm; MCSF; BAP025; PG-M-CSF; Mhdabap25
Summary: Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including macrophage homeostasis; mammary gland development; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 14.8), mammary gland adult (RPKM 13.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.3; 3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107648364..107668048, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107741048..107760469, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis.
Title: Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis.
Elevated expression of the colony-stimulating factor 1 (CSF1) induces prostatic intraepithelial neoplasia dependent of epithelial-Gp130.
Title: Elevated expression of the colony-stimulating factor 1 (CSF1) induces prostatic intraepithelial neoplasia dependent of epithelial-Gp130.
The CSF1-CSF1R pathway in the trigeminal ganglion mediates trigeminal neuralgia via inflammatory responses in mice.
Title: The CSF1-CSF1R pathway in the trigeminal ganglion mediates trigeminal neuralgia via inflammatory responses in mice.
Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype.
Title: Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype.
Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism.
Title: Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism.
Role of macrophage colony stimulating factor and interferon regulatory factor 7 in modulating the immune profile of mouse testicular macrophages.
Title: Role of macrophage colony stimulating factor and interferon regulatory factor 7 in modulating the immune profile of mouse testicular macrophages.
CSF-1 and Notch signaling cooperate in macrophage instruction and tissue repair during peripheral limb ischemia.
Title: CSF-1 and Notch signaling cooperate in macrophage instruction and tissue repair during peripheral limb ischemia.
MYC regulates CSF1 expression via microRNA 17/20a to modulate tumor-associated macrophages in osteosarcoma.
Title: MYC regulates CSF1 expression via microRNA 17/20a to modulate tumor-associated macrophages in osteosarcoma.
Host M-CSF induced gene expression drives changes in susceptible and resistant mice-derived BMdMs upon Leishmania major infection.
Title: Host M-CSF induced gene expression drives changes in susceptible and resistant mice-derived BMdMs upon Leishmania major infection.
Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone.
Title: Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone.

Submit: New GeneRIF Correction See all GeneRIFs (163)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (6)
Spontaneous (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M21952 (e-PCR)
- UniSTS:124933

PMC137879P1 (e-PCR)
- UniSTS:270857

PMC150930P2 (e-PCR)
- UniSTS:271124

X05010 (e-PCR)
- UniSTS:125788

NoName (e-PCR)
- UniSTS:548211

RH127296 (e-PCR)
- UniSTS:207543

D3Mit104 (e-PCR), detects polymorphism
- UniSTS:129502

D3Mit104.1 (e-PCR), detects polymorphism
- UniSTS:129503

D3Mit104.2 (e-PCR), detects polymorphism
- UniSTS:129504

D3Mit104.3 (e-PCR), detects polymorphism
- UniSTS:129505

PMC101742P1 (e-PCR)
- UniSTS:270063

AI547928 (e-PCR)
- UniSTS:240367

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables macrophage colony-stimulating factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in developmental process involved in reproduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within macrophage homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary duct terminal end bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland fat development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of monocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of myeloid leukocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-matrix adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of leukocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microglial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of monocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mononuclear cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mononuclear cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CSF1-CSF1R complex	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: macrophage colony-stimulating factor 1

Names: osteopetrosis; proteoglycan macrophage colony-stimulating factor

NP_001107001.1

EC 2.7.10.1

NP_001107002.1

EC 2.7.10.1

NP_031804.3

EC 2.7.10.1

XP_036018771.1

EC 2.7.10.1

XP_036018772.1

EC 2.7.10.1

XP_036018773.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113529.1 → NP_001107001.1 macrophage colony-stimulating factor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001107001.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

AC140786, AI844210, S78392

Consensus CDS

CCDS51044.1

UniProtKB/Swiss-Prot

P07141

Related

ENSMUSP00000113136.2, ENSMUST00000118593.8

Conserved Domains (1) summary

pfam05337
Location:1 → 257

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
NM_001113530.1 → NP_001107002.1 macrophage colony-stimulating factor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001107002.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1 and 3 encode the same isoform.

Source sequence(s)

AC140786, CA328312, X05010

Consensus CDS

CCDS17740.1

UniProtKB/Swiss-Prot

P07141, Q3U395, Q8R3C8

UniProtKB/TrEMBL

Q3TDK0, Q3U4F9

Related

ENSMUSP00000113617.2, ENSMUST00000120243.8

Conserved Domains (1) summary

pfam05337
Location:275 → 552

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
NM_007778.4 → NP_031804.3 macrophage colony-stimulating factor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_031804.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.

Source sequence(s)

AC140786, AI844210, AK160995, BC066187

Consensus CDS

CCDS17740.1

UniProtKB/Swiss-Prot

P07141, Q3U395, Q8R3C8

UniProtKB/TrEMBL

Q3TDK0, Q3U4F9

Related

ENSMUSP00000014743.4, ENSMUST00000014743.10

Conserved Domains (1) summary

pfam05337
Location:275 → 552

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

107648364..107668048 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162880.1 → XP_036018773.1 macrophage colony-stimulating factor 1 isoform X2

Conserved Domains (1) summary

pfam05337
Location:65 → 204

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
XM_036162878.1 → XP_036018771.1 macrophage colony-stimulating factor 1 isoform X1

UniProtKB/TrEMBL

Q3TDK0, Q3U4F9

Conserved Domains (2) summary

PHA03247
Location:220 → 496

PHA03247; large tegument protein UL36; Provisional

pfam05337
Location:65 → 204

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
XM_036162879.1 → XP_036018772.1 macrophage colony-stimulating factor 1 isoform X1

UniProtKB/TrEMBL

Q3TDK0, Q3U4F9

Conserved Domains (2) summary

PHA03247
Location:220 → 496

PHA03247; large tegument protein UL36; Provisional

pfam05337
Location:65 → 204

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)