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    Zfp1 zinc finger protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 22640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp1provided by MGI
    Official Full Name
    zinc finger protein 1provided by MGI
    Primary source
    MGI:MGI:99154
    See related
    Ensembl:ENSMUSG00000055835 AllianceGenome:MGI:99154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fnp-1; Zfp-1; mkr-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; hemolymphoid system gland; liver; reproductive system; and urinary system. Orthologous to human ZFP1 (ZFP1 zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.6), CNS E14 (RPKM 6.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp1 in Genome Data Viewer
    Location:
    8 E1; 8 57.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112366606..112397740)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111643443..111671108)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 59 Neighboring gene STARR-positive B cell enhancer ABC_E112 Neighboring gene STARR-seq mESC enhancer starr_22698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114079308-114079417 Neighboring gene STARR-positive B cell enhancer ABC_E5041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114087696-114087913 Neighboring gene zinc and ring finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114116137-114116338 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114119771-114119993 Neighboring gene STARR-seq mESC enhancer starr_22705 Neighboring gene STARR-positive B cell enhancer ABC_E9323 Neighboring gene STARR-positive B cell enhancer ABC_E885 Neighboring gene STARR-positive B cell enhancer ABC_E5042 Neighboring gene STARR-seq mESC enhancer starr_22707 Neighboring gene STARR-seq mESC enhancer starr_22708 Neighboring gene lactate dehydrogenase D Neighboring gene STARR-positive B cell enhancer ABC_E10523 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1 Neighboring gene VISTA enhancer mm1686 Neighboring gene breast cancer anti-estrogen resistance 1 Neighboring gene predicted gene, 51589

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localization and differential expression of the Krüppel-associated box zinc finger proteins 1 and 54 in early mouse development. Albertsen M, et al. DNA Cell Biol, 2010 Oct. PMID 20624068
    2. A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Chowdhury K, et al. Cell, 1987 Mar 13. PMID 3815523
    3. Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. Chowdhury K, et al. Nucleic Acids Res, 1989 Dec 25. PMID 2574853, Free PMC Article
    4. Assignment of Amog (adhesion molecule on glia) gene to mouse chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17. Hsieh CL, et al. Somat Cell Mol Genet, 1990 Jul. PMID 1699290
    5. Zinc finger protein gene complexes on mouse chromosomes 8 and 11. Nadeau JH, et al. Genomics, 1990 Nov. PMID 1981050

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, this suggests a role for ZFP1 and ZFP54 in transcriptional regulation in early development.
      Title: Localization and differential expression of the Krüppel-associated box zinc finger proteins 1 and 54 in early mouse development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 1
    Names
    protein mKR1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037665.2 → NP_001032754.1  zinc finger protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      BC062970, BF719052, X16493
      Consensus CDS
      CCDS22678.1
      UniProtKB/TrEMBL
      Q3UI68
      Related
      ENSMUSP00000076964.7, ENSMUST00000077791.8
      Conserved Domains (4) summary
      COG5048
      Location:175 → 336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 47
      KRAB; KRAB box
      pfam13465
      Location:366 → 390
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001358993.1 → NP_001345922.1  zinc finger protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate frame-shifting splice site, compared to variant 1, which results in the use of an in-frame downstream start codon and a protein (isoform 3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC122364, AK153830
      Consensus CDS
      CCDS90463.1
      UniProtKB/TrEMBL
      A0A1D5RLU7
      Related
      ENSMUSP00000148511.2, ENSMUST00000212072.2
      Conserved Domains (3) summary
      COG5048
      Location:142 → 303
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:292 → 312
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:333 → 357
      zf-H2C2_2; Zinc-finger double domain

    3. NM_011742.2 → NP_035872.2  zinc finger protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AC122364, X16493
      Consensus CDS
      CCDS85614.1
      UniProtKB/TrEMBL
      A0A1D5RLC5
      Related
      ENSMUSP00000148310.2, ENSMUST00000211926.2
      Conserved Domains (4) summary
      COG5048
      Location:161 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 33
      KRAB; KRAB box
      pfam13465
      Location:352 → 376
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_156445.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122364
      Related
      ENSMUST00000212206.2

    2. NR_156446.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122364

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112366606..112397740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153883.1 → XP_036009776.1  zinc finger protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5RLU7
      Conserved Domains (3) summary
      COG5048
      Location:142 → 303
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:292 → 312
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:333 → 357
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030243418.2 → XP_030099278.1  zinc finger protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3UI68
      Conserved Domains (4) summary
      COG5048
      Location:175 → 336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 47
      KRAB; KRAB box
      pfam13465
      Location:366 → 390
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030243420.2 → XP_030099280.1  zinc finger protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLC5
      Conserved Domains (4) summary
      COG5048
      Location:161 → 322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 33
      KRAB; KRAB box
      pfam13465
      Location:352 → 376
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08042.3 GenPept UniProtKB/Swiss-Prot:P08042

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