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    Dppa4 developmental pluripotency associated 4 [ Mus musculus (house mouse) ]

    Gene ID: 73693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dppa4provided by MGI
    Official Full Name
    developmental pluripotency associated 4provided by MGI
    Primary source
    MGI:MGI:2157525
    See related
    Ensembl:ENSMUSG00000058550 AllianceGenome:MGI:2157525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ECAT15-1; 2410091M23Rik
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within lung-associated mesenchyme development. Located in nucleus. Is expressed in several structures, including blastocyst; early embryo; foregut; gonad; and nose. Orthologous to human DPPA4 (developmental pluripotency associated 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Dppa4 in Genome Data Viewer
    Location:
    16 B5; 16 30.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48104098..48114655)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48283735..48294292)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6430553K19 gene Neighboring gene STARR-seq mESC enhancer starr_40937 Neighboring gene peroxiredoxin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40940 Neighboring gene STARR-seq mESC enhancer starr_40944 Neighboring gene developmental pluripotency associated 2 Neighboring gene predicted gene 5485

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis. Madan B, et al. Mol Cell Biol, 2009 Jun. PMID 19332562, Free PMC Article
    2. Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage. Masaki H, et al. J Biol Chem, 2007 Nov 9. PMID 17855347
    3. DPPA4 modulates chromatin structure via association with DNA and core histone H3 in mouse embryonic stem cells. Masaki H, et al. Genes Cells, 2010 Apr 1. PMID 20298437
    4. Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development. Gretarsson KH, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572256
    5. Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Eckersley-Maslin MA, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572255, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
      Title: Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
    2. DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.
      Title: DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.
    3. Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
      Title: Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
    4. Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.
      Title: Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.
    5. Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
      Title: Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
    6. Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.
      Title: Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.
    7. The paralog proteins DPPA2 and DPPA4 as necessary for the activation of Dux and LINE-1 expression in mESCs.
      Title: DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells.
    8. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
      Title: Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency.
    9. identifies EBP1 as a novel pluripotency cofactor and provides insight into potential mechanisms used by DPPA4 in regulating pluripotency through its association with EBP1
      Title: ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells.
    10. Dppa2 and Dppa4 directly regulate the 2C-like cell population and associated transcripts, including Dux and the Zscan4 cluster.
      Title: Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lung-associated mesenchyme development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lung-associated mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    developmental pluripotency-associated protein 4
    Names
    embryonic stem cell-associated transcript 15-1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018002.1 → NP_001018002.1  developmental pluripotency-associated protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AK033197, BY731814, CAAA01133063
      Consensus CDS
      CCDS28208.1
      UniProtKB/TrEMBL
      E9PUG8
      Related
      ENSMUSP00000093748.2, ENSMUST00000050705.4
      Conserved Domains (2) summary
      pfam14047
      Location:169 → 235
      DCR; Dppa2/4 conserved region
      pfam14049
      Location:73 → 157
      Dppa2_A; Dppa2/4 conserved region in higher vertebrates

    2. NM_028610.2 → NP_082886.2  developmental pluripotency-associated protein 4 isoform 1

      See identical proteins and their annotated locations for NP_082886.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK033197, BC064754, CAAA01133063
      Consensus CDS
      CCDS28209.1
      UniProtKB/Swiss-Prot
      Q6P228, Q810Y6, Q8CCG4
      Related
      ENSMUSP00000093749.2, ENSMUST00000096045.9
      Conserved Domains (2) summary
      pfam14047
      Location:221 → 287
      DCR; Dppa2/4 conserved region
      pfam14049
      Location:125 → 209
      Dppa2_A; Dppa2/4 conserved region in higher vertebrates

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      48104098..48114655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CCG4.2 GenPept UniProtKB/Swiss-Prot:Q8CCG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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