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    Slc16a12 solute carrier family 16 (monocarboxylic acid transporters), member 12 [ Mus musculus (house mouse) ]

    Gene ID: 240638, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc16a12provided by MGI
    Official Full Name
    solute carrier family 16 (monocarboxylic acid transporters), member 12provided by MGI
    Primary source
    MGI:MGI:2147716
    See related
    Ensembl:ENSMUSG00000009378 AllianceGenome:MGI:2147716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCT 12; 3230401A21
    Summary
    Predicted to enable creatine transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity; and uniporter activity. Predicted to be involved in creatine transmembrane transport and creatinine metabolic process. Located in basolateral plasma membrane. Is expressed in several structures, including brain ventricle and choroid plexus; endocardial tissue; metanephros; olfactory epithelium; and pancreas. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 20.0), liver adult (RPKM 8.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Slc16a12 in Genome Data Viewer
    Location:
    19 C1; 19 29.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34645801..34725223, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34668401..34747493, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene interferon induced protein with tetratricpeptide repeats 1B like 1 Neighboring gene interferon induced protein with tetratricopeptide repeats 1B like 2 Neighboring gene calponin2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45998 Neighboring gene STARR-positive B cell enhancer ABC_E9997 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene STARR-seq mESC enhancer starr_46000 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene, 18425 Neighboring gene STARR-seq mESC enhancer starr_46002 Neighboring gene STARR-seq mESC enhancer starr_46003 Neighboring gene STARR-seq mESC enhancer starr_46004 Neighboring gene predicted gene, 22082 Neighboring gene pantothenate kinase 1 Neighboring gene microRNA 107

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables creatine transmembrane transporter activity  
    enables creatine transmembrane transporter activity  
    enables transmembrane transporter activity  
    enables uniporter activity  
    enables uniporter activity  
    Process Evidence Code Pubs
    involved_in creatine transmembrane transport  
    involved_in creatine transmembrane transport  
    involved_in creatine transmembrane transport  
    involved_in creatinine metabolic process  
    involved_in creatinine metabolic process  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    monocarboxylate transporter 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172838.4NP_766426.1  monocarboxylate transporter 12

      See identical proteins and their annotated locations for NP_766426.1

      Status: VALIDATED

      Source sequence(s)
      AC016791, AC125259
      Consensus CDS
      CCDS29767.1
      UniProtKB/Swiss-Prot
      Q14CF9, Q14DR7, Q8BGC3
      Related
      ENSMUSP00000009522.4, ENSMUST00000009522.4
      Conserved Domains (1) summary
      cd17424
      Location:18431
      MFS_MCT12; Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      34645801..34725223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527078.5XP_006527141.1  monocarboxylate transporter 12 isoform X1

      See identical proteins and their annotated locations for XP_006527141.1

      UniProtKB/Swiss-Prot
      Q14CF9, Q14DR7, Q8BGC3
      Conserved Domains (1) summary
      cd17424
      Location:18431
      MFS_MCT12; Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters
    2. XM_011247246.3XP_011245548.1  monocarboxylate transporter 12 isoform X1

      See identical proteins and their annotated locations for XP_011245548.1

      UniProtKB/Swiss-Prot
      Q14CF9, Q14DR7, Q8BGC3
      Conserved Domains (1) summary
      cd17424
      Location:18431
      MFS_MCT12; Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters
    3. XM_006527079.4XP_006527142.1  monocarboxylate transporter 12 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:22416
      MFS; Major Facilitator Superfamily
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