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    Rapgefl1 Rap guanine nucleotide exchange factor (GEF)-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 268480, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rapgefl1provided by MGI
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF)-like 1provided by MGI
    Primary source
    MGI:MGI:3611446
    See related
    Ensembl:ENSMUSG00000038020 AllianceGenome:MGI:3611446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230105J10
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RAPGEFL1 (Rap guanine nucleotide exchange factor like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 41.7), frontal lobe adult (RPKM 28.2) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rapgefl1 in Genome Data Viewer
    Location:
    11 D; 11 62.7 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98727611..98744519)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98836785..98853009)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12359 Neighboring gene male specific lethal 1 Neighboring gene STARR-positive B cell enhancer ABC_E5276 Neighboring gene exon junction complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E9145 Neighboring gene WAS/WASL interacting protein family, member 2 Neighboring gene VISTA enhancer mm1323 Neighboring gene STARR-positive B cell enhancer ABC_E203 Neighboring gene cell division cycle 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    2. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080925.1 → NP_001074394.1  rap guanine nucleotide exchange factor-like 1

      See identical proteins and their annotated locations for NP_001074394.1

      Status: VALIDATED

      Source sequence(s)
      AL590963
      Consensus CDS
      CCDS36303.1
      UniProtKB/Swiss-Prot
      A1L3T1, Q68EF8
      Related
      ENSMUSP00000103103.3, ENSMUST00000107479.3
      Conserved Domains (1) summary
      smart00147
      Location:420 → 658
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98727611..98744519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533411.4 → XP_006533474.1  rap guanine nucleotide exchange factor-like 1 isoform X1

      Conserved Domains (1) summary
      smart00147
      Location:150 → 388
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68EF8.2 GenPept UniProtKB/Swiss-Prot:Q68EF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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