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    Safb2 scaffold attachment factor B2 [ Mus musculus (house mouse) ]

    Gene ID: 224902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Safb2provided by MGI
    Official Full Name
    scaffold attachment factor B2provided by MGI
    Primary source
    MGI:MGI:2146808
    See related
    Ensembl:ENSMUSG00000042625 AllianceGenome:MGI:2146808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0138
    Summary
    Predicted to enable identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within Sertoli cell differentiation and regulation of androgen receptor signaling pathway. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human SAFB2 (scaffold attachment factor B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.5), spleen adult (RPKM 17.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Safb2 in Genome Data Viewer
    Location:
    17 D; 17 29.39 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56867971..56891673, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56560971..56584675, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc and ring finger 4 Neighboring gene TINCR ubiquitin domain containing Neighboring gene STARR-positive B cell enhancer ABC_E5623 Neighboring gene scaffold attachment factor B Neighboring gene STARR-positive B cell enhancer ABC_E8687 Neighboring gene mitochondrial contact site and cristae organizing system subunit 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1. Jiang S, et al. Dis Model Mech, 2015 Sep. PMID 26092125, Free PMC Article
    2. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. Townson SM, et al. J Biol Chem, 2003 May 30. PMID 12660241
    3. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. Li R, et al. PLoS Genet, 2016 Jun. PMID 27352031, Free PMC Article
    4. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
    5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. despite a high degree of sequence similarity, SAFB1(-/-) and SAFB2(-/-) mice do not totally phenocopy each other
      Title: Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Sertoli cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of androgen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    scaffold attachment factor B2
    Names
    SAF-B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029979.4 → NP_001025150.2  scaffold attachment factor B2 isoform 1

      See identical proteins and their annotated locations for NP_001025150.2

      Status: VALIDATED

      Source sequence(s)
      CT485788
      Consensus CDS
      CCDS28907.2
      UniProtKB/Swiss-Prot
      Q80YR5, Q8K153
      Related
      ENSMUSP00000074953.6, ENSMUST00000075510.12
      Conserved Domains (3) summary
      COG0724
      Location:413 → 540
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam02037
      Location:25 → 59
      SAP; SAP domain
      cl17169
      Location:450 → 525
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001355463.2 → NP_001342392.1  scaffold attachment factor B2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT485788
      Conserved Domains (2) summary
      smart00513
      Location:25 → 58
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cl17169
      Location:450 → 525
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001414449.1 → NP_001401378.1  scaffold attachment factor B2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT485788

    4. NM_001414450.1 → NP_001401379.1  scaffold attachment factor B2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT485788

    5. NM_001414451.1 → NP_001401380.1  scaffold attachment factor B2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT485788

    6. NM_001414452.1 → NP_001401381.1  scaffold attachment factor B2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT485788

    7. NM_001414453.1 → NP_001401382.1  scaffold attachment factor B2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT485788

    8. NM_001414454.1 → NP_001401383.1  scaffold attachment factor B2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT485788

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56867971..56891673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524157.4 → XP_006524220.1  scaffold attachment factor B2 isoform X1

      Conserved Domains (2) summary
      smart00513
      Location:97 → 130
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cl17169
      Location:522 → 597
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_036160557.1 → XP_036016450.1  scaffold attachment factor B2 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:3 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_036160556.1 → XP_036016449.1  scaffold attachment factor B2 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:3 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_036160555.1 → XP_036016448.1  scaffold attachment factor B2 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:3 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_006524159.4 → XP_006524222.1  scaffold attachment factor B2 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:247 → 322
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_036160558.1 → XP_036016451.1  scaffold attachment factor B2 isoform X6

      Conserved Domains (1) summary
      cl17169
      Location:3 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_036160559.1 → XP_036016452.1  scaffold attachment factor B2 isoform X6

      Conserved Domains (1) summary
      cl17169
      Location:3 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_004939520.1 RNA Sequence

    2. XR_003952112.2 RNA Sequence

    3. XR_003952113.2 RNA Sequence

    4. XR_001782072.3 RNA Sequence

    5. XR_004939519.1 RNA Sequence

    6. XR_004939521.1 RNA Sequence

    7. XR_001782071.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YR5.2 GenPept UniProtKB/Swiss-Prot:Q80YR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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