Nppa natriuretic peptide type A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nppaprovided by MGI
Official Full Name: natriuretic peptide type Aprovided by MGI
Primary source: MGI:MGI:97367
See related: Ensembl:ENSMUSG00000041616 AllianceGenome:MGI:97367
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ANP; Anf; CDD; Pnd
Summary: This gene encodes members of the natriuretic family of peptides that play an important role in the control of extracellular fluid volume and electrolyte homeostasis. The encoded protein precursor undergoes proteolytic processing to generate multiple functional peptides. Mice lacking the encoded peptides exhibit salt-sensitive hypertension. The transgenic overexpression of the encoded peptides in mice decreases arterial blood pressure without inducing diuresis and natriuresis. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 4. [provided by RefSeq, Oct 2015]
Expression: Restricted expression toward heart adult (RPKM 1334.2) See more
Orthologs: human all
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Genomic context

Location:: 4 E1; 4 78.66 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148085179..148086531)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148000722..148002074)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-atrial natriuretic peptide (ANP)4-23 attenuates renal fibrosis in deoxycorticosterone-acetate-salt hypertensive mice.
Title: C-atrial natriuretic peptide (ANP)(4-23) attenuates renal fibrosis in deoxycorticosterone-acetate-salt hypertensive mice.
Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription.
Title: Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription.
NPPA/atrial natriuretic peptide is an extracellular modulator of autophagy in the heart.
Title: NPPA/atrial natriuretic peptide is an extracellular modulator of autophagy in the heart.
Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling.
Title: Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling.
Loss of NPPA-AS1 promotes heart regeneration by stabilizing SFPQ-NONO heteromer-induced DNA repair.
Title: Loss of NPPA-AS1 promotes heart regeneration by stabilizing SFPQ-NONO heteromer-induced DNA repair.
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart.
Title: Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart.
Antisense regulation of atrial natriuretic peptide expression.
Title: Antisense regulation of atrial natriuretic peptide expression.
NPPA variant p.Ile138Thr causes atrial fibrillation by activating TNF-alpha, NF-kappaB, and IL-1beta signaling, inflammation, and fibrosis.
Title: Mutation in NPPA causes atrial fibrillation by activating inflammation and cardiac fibrosis in a knock-in rat model.
we describe a novel PPARdelta-dependent molecular cascade involving microRNA-29a (miR-29a) and atrial natriuretic factor (ANF), which is reactivated in cardiac hypertrophy
Title: miR-29a attenuates cardiac hypertrophy through inhibition of PPARδ expression.
findings indicate that beige-like adipocytes induce ANP secretion, which may contribute to improving obesity-associated metabolic disease.
Title: Expression and Secretion of an Atrial Natriuretic Peptide in Beige-Like 3T3-L1 Adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nppa (e-PCR), detects polymorphism
- UniSTS:463423

PMC123178P1 (e-PCR)
- UniSTS:270444

PMC316718P1 (e-PCR)
- UniSTS:273041

Nppa (e-PCR), detects polymorphism
- UniSTS:259242

Nppa (e-PCR), detects polymorphism
- UniSTS:144055

Nppa (e-PCR), detects polymorphism
- UniSTS:144056

Nppa (e-PCR), detects polymorphism
- UniSTS:144057

Nppa (e-PCR), detects polymorphism
- UniSTS:496057

NoName (e-PCR)
- UniSTS:547523

Nppa (e-PCR), detects polymorphism
- UniSTS:547523

Nppa (e-PCR), detects polymorphism
- UniSTS:167638

PMC26660P3 (e-PCR)
- UniSTS:272346

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor binding	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of cGMP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cardiac muscle hypertrophy in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collecting lymphatic vessel constriction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic signaling via neuropeptide	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in mast cell granule	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: natriuretic peptides A

Names: atrial natriuretic factor prohormone; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; natriuretic peptide precursor type A; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.