Dock4 dedicator of cytokinesis 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dock4provided by MGI
Official Full Name: dedicator of cytokinesis 4provided by MGI
Primary source: MGI:MGI:1918006
See related: Ensembl:ENSMUSG00000035954 AllianceGenome:MGI:1918006
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0716; 5330406C03; C030023J22; 6330411N01Rik
Summary: Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in cell chemotaxis; negative regulation of vascular associated smooth muscle contraction; and positive regulation of vascular associated smooth muscle cell migration. Located in stereocilium. Is expressed in dorsal aorta; ovary; and testis. Orthologous to human DOCK4 (dedicator of cytokinesis 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cortex adult (RPKM 9.4), lung adult (RPKM 8.7) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 B1; 12 18.06 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (40495956..40896873)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (40445957..40846874)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age.
Title: Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age.
DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function.
Title: DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function.
DOCK4 regulates ghrelin production in gastric X/A-like cells.
Title: DOCK4 regulates ghrelin production in gastric X/A-like cells.
Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice.
Title: Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice.
DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.
Title: DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.
Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function.
Title: Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function.
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
Title: SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.
Dock4 binds to SH3YL1 through the C-terminal proline-rich region.
Title: Dock4 forms a complex with SH3YL1 and regulates cancer cell migration.
The Atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
Title: The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
Rac-DOCK4-actin-binding protein harmonin-activated signaling pathway is possibly involved in regulating actin cytoskeleton organization in stereocilia of the inner ear.
Title: An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF263288 (e-PCR), detects polymorphism
- UniSTS:164889

NoName (e-PCR)
- UniSTS:224715

MT1845 (e-PCR)
- UniSTS:126703

D12Mit148.1 (e-PCR), detects polymorphism
- UniSTS:126704

NoName (e-PCR)
- UniSTS:224498

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium bundle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dedicator of cytokinesis protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172803.2 → NP_766391.2 dedicator of cytokinesis protein 4

See identical proteins and their annotated locations for NP_766391.2

Status: VALIDATED

Source sequence(s)

AK122353, BB641326, CAAA01013241

Consensus CDS

CCDS25895.1

UniProtKB/Swiss-Prot

B2RUG6, P59764

Related

ENSMUSP00000047387.7, ENSMUST00000037488.8

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

40495956..40896873

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515085.3 → XP_006515148.1 dedicator of cytokinesis protein 4 isoform X1

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam03154
Location:1731 → 1937

Atrophin-1; Atrophin-1 family

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_006515089.3 → XP_006515152.1 dedicator of cytokinesis protein 4 isoform X6

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_006515090.3 → XP_006515153.1 dedicator of cytokinesis protein 4 isoform X7

UniProtKB/TrEMBL

A0A1Y7VLY2

Related

ENSMUSP00000152420.2, ENSMUST00000220912.2

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_006515088.3 → XP_006515151.1 dedicator of cytokinesis protein 4 isoform X4

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_030246698.1 → XP_030102558.1 dedicator of cytokinesis protein 4 isoform X5

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam06484
Location:1701 → 1832

Ten_N; Teneurin Intracellular Region

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_017315054.2 → XP_017170543.1 dedicator of cytokinesis protein 4 isoform X9

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_006515086.3 → XP_006515149.1 dedicator of cytokinesis protein 4 isoform X2

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1197 → 1587

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam03154
Location:1722 → 1928

Atrophin-1; Atrophin-1 family

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_006515087.3 → XP_006515150.1 dedicator of cytokinesis protein 4 isoform X3

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1197 → 1587

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam06484
Location:1710 → 1841

Ten_N; Teneurin Intracellular Region

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_036157392.1 → XP_036013285.1 dedicator of cytokinesis protein 4 isoform X8

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1197 → 1587

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus