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    Psg19 pregnancy specific beta-1-glycoprotein 19 [ Mus musculus (house mouse) ]

    Gene ID: 26439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psg19provided by MGI
    Official Full Name
    pregnancy specific beta-1-glycoprotein 19provided by MGI
    Primary source
    MGI:MGI:1347252
    See related
    Ensembl:ENSMUSG00000004542 AllianceGenome:MGI:1347252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGM7; Cea4; Cea-4
    Summary
    Predicted to be involved in T cell activation and immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Is expressed in labyrinthine zone and spongiotrophoblast. Orthologous to human CEACAM7 (CEA cell adhesion molecule 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 50.9) See more
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    Genomic context

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    See Psg19 in Genome Data Viewer
    Location:
    7 A3; 7 9.31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18523045..18532471, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18789120..18798546, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pregnancy-specific beta-1-glycoprotein 22 Neighboring gene STARR-seq mESC enhancer starr_18174 Neighboring gene predicted gene, 24464 Neighboring gene STARR-seq mESC enhancer starr_18175 Neighboring gene synaptonemal complex protein 1, pseudogene 1 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 1 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mapping of murine YACs containing the genes Cea2 and Cea4 after B1-PCR amplification and FISH-analysis. Rettenberger G, et al. Chromosome Res, 1995 Dec. PMID 8581299
    2. Coordinate expression of splice variants of the murine pregnancy-specific glycoprotein (PSG) gene family during placental development. Kromer B, et al. Eur J Biochem, 1996 Dec 1. PMID 8973644
    3. Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature. Wynne F, et al. Reproduction, 2006 Apr. PMID 16595723
    4. HOP/NECC1, a novel regulator of mouse trophoblast differentiation. Asanoma K, et al. J Biol Chem, 2007 Aug 17. PMID 17576768
    5. Transient reduction of placental angiogenesis in PAI-1-deficient mice. Labied S, et al. Physiol Genomics, 2011 Feb 24. PMID 21119013

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117673

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy specific glycoprotein 19
    Names
    carcinoembryonic antigen 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011964.2 → NP_036094.2  pregnancy specific glycoprotein 19

      See identical proteins and their annotated locations for NP_036094.2

      Status: VALIDATED

      Source sequence(s)
      AA408180, AK145915, AV034276, BC099467
      Consensus CDS
      CCDS20877.1
      UniProtKB/TrEMBL
      P70161, P70162, Q4KL31, Q62054
      Related
      ENSMUSP00000004657.7, ENSMUST00000004657.14
      Conserved Domains (3) summary
      cd05774
      Location:276 → 380
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00408
      Location:400 → 461
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:395 → 472
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18523045..18532471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540007.4 → XP_006540070.1  pregnancy specific glycoprotein 19 isoform X1

      Conserved Domains (2) summary
      smart00408
      Location:276 → 337
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:152 → 256
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    Nucleotide Protein Strain
    Heading Accession and Version

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