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    Sdhaf3 succinate dehydrogenase complex assembly factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 71238, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sdhaf3provided by MGI
    Official Full Name
    succinate dehydrogenase complex assembly factor 3provided by MGI
    Primary source
    MGI:MGI:1913288
    See related
    Ensembl:ENSMUSG00000042505 AllianceGenome:MGI:1913288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acn9; 0610005M07Rik; 4933430A16Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex II assembly and succinate metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrial intermembrane space. Orthologous to human SDHAF3 (succinate dehydrogenase complex assembly factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.0), CNS E14 (RPKM 2.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sdhaf3 in Genome Data Viewer
    Location:
    6 A1; 6 2.83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (6956004..7039661)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (6955971..7039661)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53323 Neighboring gene STARR-seq mESC enhancer starr_15088 Neighboring gene predicted gene, 22155 Neighboring gene centromere protein E pseudogene Neighboring gene STARR-seq mESC enhancer starr_15089 Neighboring gene predicted gene, 19272

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acn9 is a novel protein of gluconeogenesis that is located in the mitochondrial intermembrane space. Dennis RA, et al. Eur J Biochem, 1999 Apr. PMID 10103055
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex II assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    succinate dehydrogenase assembly factor 3, mitochondrial
    Names
    ACN9 homolog
    SDH assembly factor 3
    protein ACN9 homolog, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077713.2 → NP_001071181.1  succinate dehydrogenase assembly factor 3, mitochondrial isoform b precursor

      See identical proteins and their annotated locations for NP_001071181.1

      Status: VALIDATED

      Source sequence(s)
      AC122240, AC146599
      Consensus CDS
      CCDS39423.1
      UniProtKB/Swiss-Prot
      Q8BQU3, Q8BT21
      UniProtKB/TrEMBL
      Q0VF92, Q3V4A6
      Related
      ENSMUSP00000040935.5, ENSMUST00000040826.6
      Conserved Domains (1) summary
      pfam13233
      Location:9 → 105
      Complex1_LYR_2; Complex1_LYR-like

    2. NM_001417719.1 → NP_001404648.1  succinate dehydrogenase assembly factor 3, mitochondrial isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC122240, AC146599

    3. NM_001417720.1 → NP_001404649.1  succinate dehydrogenase assembly factor 3, mitochondrial isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC122240, AC146599

    4. NM_001417721.1 → NP_001404650.1  succinate dehydrogenase assembly factor 3, mitochondrial isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC122240

    RNA

    1. NR_184564.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122240
      Related
      ENSMUST00000123848.2

    2. NR_184565.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122240, AC146599

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      6956004..7039661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQU3.1 GenPept UniProtKB/Swiss-Prot:Q8BQU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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