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    Sik3 SIK family kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 70661, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Sik3provided by MGI
    Official Full Name
    SIK family kinase 3provided by MGI
    Primary source
    MGI:MGI:2446296
    See related
    Ensembl:ENSMUSG00000034135 AllianceGenome:MGI:2446296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Qsk; SIK-3; mKIAA0999; 5730525O22Rik; 9030204A07Rik
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Acts upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Located in cytoplasm. Is expressed in Meckel's cartilage and vibrissa. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 12.2), adrenal adult (RPKM 10.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sik3 in Genome Data Viewer
    Location:
    9 A5.2; 9 25.36 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45924099..46135492)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (46012820..46224194)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A830035O19 gene Neighboring gene SID1 transmembrane family, member 2 Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E8289 Neighboring gene STARR-seq mESC enhancer starr_24013 Neighboring gene STARR-seq mESC enhancer starr_24014 Neighboring gene predicted gene, 46110 Neighboring gene STARR-seq mESC enhancer starr_24018 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45928283-45928392 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 9 Neighboring gene STARR-seq mESC enhancer starr_24022 Neighboring gene apolipoprotein A-I Neighboring gene apolipoprotein C-III

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation. Kamei K, et al. J Bone Miner Res, 2024 Sep 2. PMID 39030684
    2. Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation. Kosai A, et al. Biochem Biophys Res Commun, 2019 Sep 3. PMID 31280862
    3. A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice. Honda T, et al. Proc Natl Acad Sci U S A, 2018 Oct 9. PMID 30254177, Free PMC Article
    4. Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice. Suzuki-Abe H, et al. Neurosci Res, 2022 Apr. PMID 34856199
    5. The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia. Wang K, et al. Cell Mol Life Sci, 2022 Jul 21. PMID 35864266, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation.
      Title: Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation.
    2. Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABAAR alpha1 Expression.
      Title: Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABA(A)R α1 Expression.
    3. Sleep need, the key regulator of sleep homeostasis, is indicated and controlled by phosphorylation of threonine 221 in salt-inducible kinase 3.
      Title: Sleep need, the key regulator of sleep homeostasis, is indicated and controlled by phosphorylation of threonine 221 in salt-inducible kinase 3.
    4. Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning.
      Title: Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning.
    5. Face validation and pharmacologic analysis of Sik3[Sleepy] mutant mouse as a possible model of idiopathic hypersomnia.
      Title: Face validation and pharmacologic analysis of Sik3(Sleepy) mutant mouse as a possible model of idiopathic hypersomnia.
    6. SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
      Title: SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
    7. Kinase signalling in excitatory neurons regulates sleep quantity and depth.
      Title: Kinase signalling in excitatory neurons regulates sleep quantity and depth.
    8. Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase.
      Title: Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase.
    9. The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia.
      Title: The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia.
    10. Salt inducible kinases 2 and 3 are required for thymic T cell development.
      Title: Salt inducible kinases 2 and 3 are required for thymic T cell development.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90906, MGC91236

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC2 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SIK3
    Names
    salt-inducible kinase 3
    serine/threonine-protein kinase QSK
    NP_081774.3
    XP_006510653.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027498.3 → NP_081774.3  serine/threonine-protein kinase SIK3

      Status: VALIDATED

      Source sequence(s)
      AK129257, BC080688, BG229919, CJ171970
      Consensus CDS
      CCDS23140.2
      UniProtKB/Swiss-Prot
      E9PU87, Q641L5, Q66JZ5, Q6P4S6, Q6ZQ09, Q8K075, Q9CYD5
      UniProtKB/TrEMBL
      F6S7W6
      Related
      ENSMUSP00000121032.2, ENSMUST00000126865.8
      Conserved Domains (3) summary
      smart00220
      Location:66 → 317
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14410
      Location:346 → 390
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45924099..46135492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510590.4 → XP_006510653.1  serine/threonine-protein kinase SIK3 isoform X1

      UniProtKB/TrEMBL
      F6S7W6
      Related
      ENSMUSP00000112749.3, ENSMUST00000120463.9
      Conserved Domains (2) summary
      cd14410
      Location:346 → 390
      UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4S6.4 GenPept UniProtKB/Swiss-Prot:Q6P4S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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