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    Atad2b ATPase family, AAA domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 320817, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atad2bprovided by MGI
    Official Full Name
    ATPase family, AAA domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:2444798
    See related
    Ensembl:ENSMUSG00000052812 AllianceGenome:MGI:2444798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110014E10Rik; D530031C13Rik
    Summary
    Predicted to enable ATP hydrolysis activity; chromatin binding activity; and lysine-acetylated histone binding activity. Predicted to be involved in nucleosome assembly; nucleosome disassembly; and transcription initiation-coupled chromatin remodeling. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human ATAD2B (ATPase family AAA domain containing 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.7), CNS E14 (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atad2b in Genome Data Viewer
    Location:
    12 A1.1; 12 2.15 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4964404..5097396)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4914404..5047396)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31460 Neighboring gene MFSD2 lysolipid transporter B, sphingolipid Neighboring gene STARR-seq mESC enhancer starr_31462 Neighboring gene STARR-seq mESC enhancer starr_31463 Neighboring gene UBX domain protein 2A Neighboring gene STARR-seq mESC enhancer starr_31464 Neighboring gene STARR-positive B cell enhancer ABC_E5317 Neighboring gene STARR-seq mESC enhancer starr_31466 Neighboring gene predicted gene, 23167 Neighboring gene RAB11B, member RAS oncogene family pseudogene Neighboring gene kelch-like 29 Neighboring gene STARR-seq mESC enhancer starr_31469 Neighboring gene STARR-seq mESC enhancer starr_31470 Neighboring gene VISTA enhancer mm1338 Neighboring gene predicted gene, 51980

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Farini D, et al. Cell Rep, 2020 Jun 2. PMID 32492419
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 
    • Transgenic (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1240

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATPase family AAA domain-containing protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362349.1 → NP_001349278.1  ATPase family AAA domain-containing protein 2B

      Status: VALIDATED

      Source sequence(s)
      AC131767, CT571254
      UniProtKB/TrEMBL
      E9Q166
      Related
      ENSMUSP00000047445.6, ENSMUST00000045664.7
      Conserved Domains (2) summary
      cd05528
      Location:959 → 1070
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      cl27568
      Location:396 → 668
      TIP49; TIP49 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4964404..5097396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515117.4 → XP_006515180.1  ATPase family AAA domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      E9Q166
      Conserved Domains (3) summary
      cd05528
      Location:959 → 1065
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      TIGR01243
      Location:396 → 668
      CDC48; AAA family ATPase, CDC48 subfamily
      cl38936
      Location:768 → 872
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006515116.4 → XP_006515179.1  ATPase family AAA domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      E9Q166
      Conserved Domains (4) summary
      cd05528
      Location:958 → 1069
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG5076
      Location:839 → 1084
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      TIGR01243
      Location:395 → 667
      CDC48; AAA family ATPase, CDC48 subfamily
      cl38936
      Location:767 → 871
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_030246779.1 → XP_030102639.1  ATPase family AAA domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      cd05528
      Location:304 → 415
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG0464
      Location:110 → 252
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      COG5076
      Location:185 → 395
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

    4. XM_017315117.1 → XP_017170606.1  ATPase family AAA domain-containing protein 2B isoform X4

      Conserved Domains (2) summary
      cd05528
      Location:304 → 410
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG0464
      Location:110 → 252
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    5. XM_036157502.1 → XP_036013395.1  ATPase family AAA domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      cd05528
      Location:304 → 415
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG0464
      Location:110 → 252
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      COG5076
      Location:185 → 395
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

    RNA

    1. XR_004937520.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001099628.1: Suppressed sequence

      Description
      NM_001099628.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.

    2. NM_177269.2: Suppressed sequence

      Description
      NM_177269.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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