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    Htra3 HtrA serine peptidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 78558, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Htra3provided by MGI
    Official Full Name
    HtrA serine peptidase 3provided by MGI
    Primary source
    MGI:MGI:1925808
    See related
    Ensembl:ENSMUSG00000029096 AllianceGenome:MGI:1925808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prsp; Tasp; 2210021K23Rik; 9530081K03Rik
    Summary
    Enables serine-type peptidase activity. Involved in negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; and proteolysis. Predicted to be located in extracellular region. Is expressed in decidua; forelimb; and tendon. Orthologous to human HTRA3 (HtrA serine peptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 98.7), subcutaneous fat pad adult (RPKM 87.5) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Htra3 in Genome Data Viewer
    Location:
    5 B3; 5 18.49 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35809370..35837157, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35652026..35679813, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12858 Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene polo like kinase, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene tRNA methyltransferase 44 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl Neighboring gene STARR-seq mESC enhancer starr_12860 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene predicted gene, 31888 Neighboring gene STARR-positive B cell enhancer ABC_E8820 Neighboring gene actin-binding LIM protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers. Bowden MA, et al. Mol Cell Endocrinol, 2010 Oct 7. PMID 20540986
    2. A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation. Nie GY, et al. Mol Hum Reprod, 2003 May. PMID 12728021
    3. HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse. Nie G, et al. Placenta, 2006 Apr-May. PMID 15951015
    4. Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood. Li Y, et al. Sci Rep, 2017 Jul 4. PMID 28676687, Free PMC Article
    5. A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging. Patterson VL, et al. J Vis Exp, 2016 Jul 14. PMID 27500671

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that HtrA3 deletion in the mother resulted in intra-uterine growth restriction (IUGR). Disorganization of labyrinthine fetal capillaries was the major placental defect when HtrA3 was absent. Mice born to HtrA3-deficient mothers, independent of their own genotype, were significantly heavier and contained a larger mass of white fat.
      Title: Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.
    2. Both mRNA and protein of HtrA3 were localized specifically in the maternal decidua. Only the maternal decidual cells, but not blood vessels or uterine NK cells that are present in large numbers, were positive for HtrA3.
      Title: HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse.
    3. Plays an important role in the formation/function of the placenta.
      Title: A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease HTRA3
    Names
    high-temperature requirement factor A3
    pregnancy-related serine protease
    probable serine protease HTRA3
    toll-associated serine protease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042615.2 → NP_001036080.1  serine protease HTRA3 isoform b precursor

      See identical proteins and their annotated locations for NP_001036080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI481644, AK008764, AK035194, AY156509
      Consensus CDS
      CCDS39071.1
      UniProtKB/Swiss-Prot
      Q9D236
      Related
      ENSMUSP00000109871.3, ENSMUST00000114233.3
      Conserved Domains (3) summary
      pfam00219
      Location:31 → 82
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:87 → 132
      Kazal_2; Kazal-type serine protease inhibitor domain
      pfam13365
      Location:181 → 325
      Trypsin_2; Trypsin-like peptidase domain

    2. NM_030127.3 → NP_084403.2  serine protease HTRA3 isoform a precursor

      See identical proteins and their annotated locations for NP_084403.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK008764, AK020653, AK035194, AY156509
      Consensus CDS
      CCDS19233.1
      UniProtKB/Swiss-Prot
      B2RRV0, Q6WLC5, Q6YDR0, Q9D236
      Related
      ENSMUSP00000084910.4, ENSMUST00000087629.10
      Conserved Domains (4) summary
      cd00987
      Location:361 → 446
      PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
      pfam00219
      Location:31 → 82
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:87 → 132
      Kazal_2; Kazal-type serine protease inhibitor domain
      pfam13365
      Location:181 → 325
      Trypsin_2; Trypsin-like peptidase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      35809370..35837157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504186.2 → XP_006504249.1  serine protease HTRA3 isoform X1

      Conserved Domains (3) summary
      TIGR02037
      Location:149 → 440
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      pfam00219
      Location:31 → 82
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:95 → 132
      Kazal_2; Kazal-type serine protease inhibitor domain

    2. XM_030254908.2 → XP_030110768.1  serine protease HTRA3 isoform X3

      Conserved Domains (1) summary
      TIGR02037
      Location:1 → 247
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    3. XM_011240796.4 → XP_011239098.1  serine protease HTRA3 isoform X2

      Conserved Domains (1) summary
      TIGR02037
      Location:1 → 255
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    RNA

    1. XR_004942587.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D236.3 GenPept UniProtKB/Swiss-Prot:Q9D236

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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