Rps6kb2 ribosomal protein S6 kinase, polypeptide 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps6kb2provided by MGI
Official Full Name: ribosomal protein S6 kinase, polypeptide 2provided by MGI
Primary source: MGI:MGI:1927343
See related: Ensembl:ENSMUSG00000024830 AllianceGenome:MGI:1927343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S6K2; S6K-beta-2
Summary: Enables protein kinase activity. Acts upstream of or within negative regulation of insulin receptor signaling pathway and protein phosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in renal vasculature. Orthologous to human RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 22.1), limb E14.5 (RPKM 19.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 3.86 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4206791..4213382, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4156792..4163383, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S6K2 loss reduces Th17 skewing and increases regulatory T cell differentiation.
Title: Context-Specific Function of S6K2 in Th Cell Differentiation.
the p70S6K isoforms have unique and redundant functions in mediating fibrogenic processes, including proliferation, migration.
Title: Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis.
S6K2 regulates hepatic energy homeostasis by repressing PPARalpha activity.
Title: S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver.
metabolic functions of S6K in vivo play a key role as a molecular interface connecting dietary lipids to the endogenous control of energy metabolism.
Title: Metabolic control by S6 kinases depends on dietary lipids.
S6K2 expression dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis
Title: Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.
mGluR-LTD is associated with PI3K-, mTOR-, and ERK-dependent alterations in the phosphorylation of S6 and S6K.
Title: mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice.
parallel increase in p70S6K activation and tau phosphorylation could be demonstrated by treating wild-type N2a cells with Abeta25-35
Title: Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction.
Data show that the absence of ribosomal protein S6 kinases 1 and 2 (S6K1 and S6K2) profoundly impairs animal viability but does not seem to affect the proliferative responses of cells derived from the distinct S6K genotypes.
Title: S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.
S6K2 is activated by IL-3 in the IL-3-dependent Ba/F3 cell line and this is mediated by mTOR and its upstream activator PI-3K but not by MAPK signal pathways.
Title: S6 kinase 2 potentiates interleukin-3-driven cell proliferation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

AI605264 (e-PCR)
- UniSTS:181182

AI790298 (e-PCR)
- UniSTS:166120

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal protein S6 kinase beta-2

Names: 70 kDa ribosomal protein S6 kinase 2; S6 kinase 2; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70 ribosomal S6 kinase beta; ribosomal protein S6 kinase, 70kD, polypeptide 2

NP_067460.1

EC 2.7.11.1

XP_006531876.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021485.3 → NP_067460.1 ribosomal protein S6 kinase beta-2

See identical proteins and their annotated locations for NP_067460.1

Status: VALIDATED

Source sequence(s)

AC109138

Consensus CDS

CCDS29419.1

UniProtKB/Swiss-Prot

Q9Z1M4

Related

ENSMUSP00000025749.8, ENSMUST00000025749.15

Conserved Domains (2) summary

smart00220
Location:67 → 328

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05584
Location:70 → 392

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

NR_153659.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC109138, BC066842

Related

ENSMUST00000154307.8
NR_153660.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC109138
NR_153661.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC109138, BC051631

Related

ENSMUST00000130469.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

4206791..4213382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531813.5 → XP_006531876.1 ribosomal protein S6 kinase beta-2 isoform X1

See identical proteins and their annotated locations for XP_006531876.1

Conserved Domains (1) summary

cd05584
Location:1 → 295

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase