Canx calnexin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Canxprovided by MGI
Official Full Name: calnexinprovided by MGI
Primary source: MGI:MGI:88261
See related: Ensembl:ENSMUSG00000020368 AllianceGenome:MGI:88261
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cnx; D11Ertd153e; 1110069N15Rik
Summary: Predicted to enable apolipoprotein binding activity; calcium ion binding activity; and ionotropic glutamate receptor binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in endoplasmic reticulum quality control compartment and nuclear membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; intestine; and musculature. Orthologous to human CANX (calnexin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 118.8), CNS E11.5 (RPKM 79.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 30.46 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (50184784..50216500, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (50293957..50325673, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ER chaperone calnexin controls mitochondrial positioning and respiration.
Title: The ER chaperone calnexin controls mitochondrial positioning and respiration.
The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis.
Title: The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis.
EBV-induced gene 3 augments IL-23Ralpha protein expression through a chaperone calnexin.
Title: EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.
Study discovered that calnexin is highly abundant in human brain endothelial cells of multiple sclerosis (MS) patients. Conversely, mice lacking calnexin exhibited resistance to experimental autoimmune encephalomyelitis induction, no evidence of immune cell infiltration into the CNS. These findings identify a link between calnexin expression in CNS endothelial cells and neuroinflammation.
Title: Calnexin is necessary for T cell transmigration into the central nervous system.
CNX has a specific role in cardiomyocyte viability and Ca(2+) cycling through its effects on endoplasmic reticulum stress, apoptosis and Ca(2+) channel expression.
Title: Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis.
Calnexin discriminates between different conformational states of GlyT2 displaying a lectin-independent chaperone activity.
Title: Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2).
calnexin and ERp57, but not calreticulin, play an important role in the biology of peripheral myelin proteins PMP22 and P0, and, consequently, these chaperones may contribute to the pathogenesis of peripheral neuropathies
Title: Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22.
Enhanced clathrin-dependent endocytosis in the absence of calnexin may contribute to the neurological phenotype of calnexin-deficient mice
Title: Enhanced clathrin-dependent endocytosis in the absence of calnexin.
Data show that the E351 mutation led to slightly enhanced ERp57 binding to calnexin, whereas W428 greatly enhanced binding of ERp57 to calnexin.
Title: Mutational analysis of calnexin.
Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5, calnexin and Itm2b during capacitation in sperm.
Title: Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Pjn2 (e-PCR), detects polymorphism
- UniSTS:498688

RH128505 (e-PCR)
- UniSTS:211813

D11Ertd153e (e-PCR), detects polymorphism
- UniSTS:167042

RH136111 (e-PCR)
- UniSTS:210106

AI988026 (e-PCR)
- UniSTS:180199

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum quality control compartment	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lumenal side of endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	HDA more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calnexin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110499.1 → NP_001103969.1 calnexin precursor

See identical proteins and their annotated locations for NP_001103969.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK004422, AK017254, AK084175, AK166649, BB857984, BX632165, BY309447

Consensus CDS

CCDS24633.1

UniProtKB/Swiss-Prot

P35564

UniProtKB/TrEMBL

Q3TXE5, Q5SUC3

Related

ENSMUSP00000137440.2, ENSMUST00000179865.8

Conserved Domains (1) summary

pfam00262
Location:72 → 441

Calreticulin; Calreticulin family
NM_001110500.1 → NP_001103970.1 calnexin precursor

See identical proteins and their annotated locations for NP_001103970.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK004422, AK017254, AK028279, AK165508, BX632165, BY309447

Consensus CDS

CCDS24633.1

UniProtKB/Swiss-Prot

P35564

UniProtKB/TrEMBL

Q3TXE5, Q5SUC3

Conserved Domains (1) summary

pfam00262
Location:72 → 441

Calreticulin; Calreticulin family
NM_007597.3 → NP_031623.1 calnexin precursor

See identical proteins and their annotated locations for NP_031623.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK004422, AK017254, AK084175, AK166649, BX632165, BY309447

Consensus CDS

CCDS24633.1

UniProtKB/Swiss-Prot

P35564

UniProtKB/TrEMBL

Q3TXE5, Q5SUC3

Related

ENSMUSP00000020637.9, ENSMUST00000020637.9

Conserved Domains (1) summary

pfam00262
Location:72 → 441

Calreticulin; Calreticulin family