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    Pgap4 post-GPI attachment to proteins GalNAc transferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 67063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgap4provided by MGI
    Official Full Name
    post-GPI attachment to proteins GalNAc transferase 4provided by MGI
    Primary source
    MGI:MGI:1914313
    See related
    Ensembl:ENSMUSG00000039611 AllianceGenome:MGI:1914313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem246; 2810432L12Rik; 9330170P15Rik
    Summary
    Predicted to enable glycosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in ganglia; nucleus pulposus; and thymus primordium. Orthologous to human PGAP4 (post-GPI attachment to proteins GalNAc transferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in stomach adult (RPKM 29.0), colon adult (RPKM 23.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgap4 in Genome Data Viewer
    Location:
    4 B1; 4 26.63 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49584506..49597876, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49584506..49597876, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 189 Neighboring gene aldolase B, fructose-bisphosphate Neighboring gene predicted gene, 33106 Neighboring gene predicted gene, 33159 Neighboring gene STARR-seq mESC enhancer starr_10187 Neighboring gene STARR-positive B cell enhancer ABC_E2112 Neighboring gene predicted gene, 45952

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. Hirata T, et al. J Biol Chem, 2022 Mar. PMID 35151686, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    post-GPI attachment to proteins factor 4
    Names
    transmembrane protein 246
    transmembrane protein C9orf125 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355503.1 → NP_001342432.1  post-GPI attachment to proteins factor 4

      Status: VALIDATED

      Source sequence(s)
      AK042679, AK045523, AL772310, CK626914, CX238824
      Consensus CDS
      CCDS18177.1
      UniProtKB/Swiss-Prot
      Q3TN50, Q91YV9, Q9CYX3
      Conserved Domains (1) summary
      cd22190
      Location:25 → 395
      PGAP4; Post-GPI attachment to proteins factor 4

    2. NM_025944.4 → NP_080220.2  post-GPI attachment to proteins factor 4

      See identical proteins and their annotated locations for NP_080220.2

      Status: VALIDATED

      Source sequence(s)
      AK042679, AK045523
      Consensus CDS
      CCDS18177.1
      UniProtKB/Swiss-Prot
      Q3TN50, Q91YV9, Q9CYX3
      Related
      ENSMUSP00000040885.3, ENSMUST00000042750.3
      Conserved Domains (1) summary
      cd22190
      Location:25 → 395
      PGAP4; Post-GPI attachment to proteins factor 4

    RNA

    1. NR_149725.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK042679, AK045523, AL772310, CK626914, CX238824

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      49584506..49597876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538195.4 → XP_006538258.1  post-GPI attachment to proteins factor 4 isoform X1

      See identical proteins and their annotated locations for XP_006538258.1

      UniProtKB/Swiss-Prot
      Q3TN50, Q91YV9, Q9CYX3
      Conserved Domains (1) summary
      cd22190
      Location:25 → 395
      PGAP4; Post-GPI attachment to proteins factor 4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YV9.1 GenPept UniProtKB/Swiss-Prot:Q91YV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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