Il13ra1 interleukin 13 receptor, alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il13ra1provided by MGI
Official Full Name: interleukin 13 receptor, alpha 1provided by MGI
Primary source: MGI:MGI:105052
See related: Ensembl:ENSMUSG00000017057 AllianceGenome:MGI:105052
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR4; Il13ra; CD213a1; IL-13r[a]; IL-13R-alpha-1
Summary: This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq, May 2015]
Expression: Ubiquitous expression in large intestine adult (RPKM 8.8), colon adult (RPKM 6.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A3.3; X 20.49 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (35375761..35434915)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (36112108..36171262)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Low IL-13Ralpha1 expression on mast cells tunes them unresponsive to IL-13.
Title: Low IL-13Rα1 expression on mast cells tunes them unresponsive to IL-13.
Interleukin-13 Receptor alpha1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis.
Title: Interleukin-13 Receptor α1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis.
IL-13Ralpha1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells.
Title: IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells.
Expression of IL4Ralpha and IL13Ralpha1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum.
Title: Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum.
Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress.
Title: Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress.
IL-13 receptor alpha 1 (IL-13Ralpha1) dendritic cell are able to take up antigen from the peritoneum and carry it to the the thymus.
Title: A distinct dendritic cell population arises in the thymus of IL-13Rα1-sufficient but not IL-13Rα1-deficient mice.
Chronic stress significantly reduced the number of substantia nigra dopaminergic neurons in Il13a1 knock-out mice.
Title: Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress.
Delivery of sIL13ralpha1 to mice by either gene transfer or recombinant protein decreases blood glucose levels. Surprisingly, the glucose-lowering effect of sIL13ralpha1 was preserved in mice lacking IL-13, demonstrating that IL-13 was not required for the effect. In contrast, deletion of IL-4 in mice eliminated the hypoglycemic effect of sIL13ralpha1.
Title: Soluble interleukin-13rα1: a circulating regulator of glucose.
findings indicate that NOD mice lacking the IL-4Ralpha/IL-13Ralpha1 heteroreceptor (HR) display resistance to Type 1 Diabetes as the rise in blood glucose level and islet inflammation were significantly delayed in these HR-deficient relative to HR-sufficient mice
Title: On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes.
IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair.
Title: A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI882074 (e-PCR)
- UniSTS:166178

Il13ra1 (e-PCR), detects polymorphism
- UniSTS:186519

Il13ra1 (e-PCR), detects polymorphism
- UniSTS:143537

NoName (e-PCR)
- UniSTS:238013

Il13ra1 (e-PCR), detects polymorphism
- UniSTS:256476

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-13 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immunoglobulin production	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-13 receptor subunit alpha-1

Names: IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; interleukin-13-binding protein; novel cytokine receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133990.5 → NP_598751.3 interleukin-13 receptor subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_598751.3

Status: REVIEWED

Source sequence(s)

AK082889, AL672038, BC052425, CK334115

Consensus CDS

CCDS30057.1

UniProtKB/Swiss-Prot

O09030, Q7TT27

UniProtKB/TrEMBL

Q8C1Z3

Related

ENSMUSP00000033418.8, ENSMUST00000033418.8

Conserved Domains (2) summary

cd00063
Location:225 → 333

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:127 → 221

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding