Fcmr Fc fragment of IgM receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcmrprovided by MGI
Official Full Name: Fc fragment of IgM receptorprovided by MGI
Primary source: MGI:MGI:1916419
See related: Ensembl:ENSMUSG00000042474 AllianceGenome:MGI:1916419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Toso; Faim3; FcmuR; IgM FcR; 1810037B05Rik
Summary: Enables IgM binding activity. Involved in humoral immune response mediated by circulating immunoglobulin; immunoglobulin transcytosis in epithelial cells; and regulation of B cell receptor signaling pathway. Acts upstream of or within inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; and negative regulation of lymphocyte apoptotic process. Located in external side of plasma membrane and trans-Golgi network membrane. Orthologous to human FCMR (Fc mu receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 125.7) and mammary gland adult (RPKM 37.6) See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.89 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (130793514..130808528)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (130865777..130880790)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differences between Human and Mouse IgM Fc Receptor (FcmicroR).
Title: Differences between Human and Mouse IgM Fc Receptor (FcµR).
during influenza A-induced pulmonary inflammation, the application of Toso-specific antibodies selectively induced IL-10-competent B cells at the site of inflammation and resulted in decreased proinflammatory cytokine production by lung T cells.
Title: Surface receptor Toso controls B cell-mediated regulation of T cell immunity.
Study demonstrated that Fcmr (Toso), the putative receptor for soluble IgM, modulates myeloid cell responses to cancer. In a syngeneic melanoma model, Fcmr ablation in myeloid cells suppressed tumor growth and extended mouse survival. Fcmr deficiency increased myeloid cell population density in this malignancy and enhanced anti-tumor immunity.
Title: Fcmr regulates mononuclear phagocyte control of anti-tumor immunity.
Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection.
Title: Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection.
these findings suggest that FcmuR plays important roles in the regulation of auto-antibody production, Mott cell formation and the differentiation of MZ B cells into plasma cells in B6.MRL Fas (lpr/lpr) mice.
Title: Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice.
FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge.
Title: Mouse IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses.
Toso is a unique regulator of inflammatory autoimmune responses with a protective role against experimental autoimmune encephalomyelitis
Title: Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.
Toso is a unique regulator of innate immune responses during bacterial infection and septic shock.
Title: Involvement of Toso in activation of monocytes, macrophages, and granulocytes.
These results identify TOSO/FAIM3 as a receptor for IgM
Title: Identification of TOSO/FAIM3 as an Fc receptor for IgM.
mTOSO overexpressing primary T lymphocytes are resistant to Fas/Fas ligand-induced apoptosis.
Title: The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (8) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488792

NoName (e-PCR)
- UniSTS:490730

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgM binding	IDA Inferred from Direct Assay more info	PubMed
enables high-affinity IgM receptor activity	ISO Inferred from Sequence Orthology more info
enables high-affinity IgM receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables polymeric immunoglobulin binding	ISO Inferred from Sequence Orthology more info
enables polymeric immunoglobulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Fc receptor-mediated immune complex endocytosis	ISO Inferred from Sequence Orthology more info
involved_in Fc receptor-mediated immune complex endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immunoglobulin transcytosis in epithelial cells	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of lymphocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: immunoglobulin mu Fc receptor

Names: Fas apoptotic inhibitory molecule 3; IgM Fc fragment receptor; regulator of Fas-induced apoptosis Toso

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405893.1 → NP_001392822.1 immunoglobulin mu Fc receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC165322
NM_026976.4 → NP_081252.1 immunoglobulin mu Fc receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_081252.1

Status: VALIDATED

Source sequence(s)

AC165322

Consensus CDS

CCDS15261.1

UniProtKB/Swiss-Prot

A1KXC4, A1KXC6, A1KXC8, A1KXC9, Q148B9, Q9D8T1

UniProtKB/TrEMBL

A0A0G2LB91

Related

ENSMUSP00000048303.6, ENSMUST00000038829.7

Conserved Domains (1) summary

cd05716
Location:25 → 120

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)