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    Kynu kynureninase [ Mus musculus (house mouse) ]

    Gene ID: 70789, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kynuprovided by MGI
    Official Full Name
    kynureninaseprovided by MGI
    Primary source
    MGI:MGI:1918039
    See related
    Ensembl:ENSMUSG00000026866 AllianceGenome:MGI:1918039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4432411A05Rik
    Summary
    Predicted to enable kynureninase activity; protein homodimerization activity; and pyridoxal phosphate binding activity. Predicted to be involved in several processes, including aromatic amino acid metabolic process; quinolinate biosynthetic process; and response to type II interferon. Located in mitochondrion. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 9.9), liver E18 (RPKM 4.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kynu in Genome Data Viewer
    Location:
    2 B; 2 25.64 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (43445270..43572734)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (43555258..43683048)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54112 Neighboring gene STARR-seq mESC enhancer starr_04383 Neighboring gene STARR-seq mESC enhancer starr_04384 Neighboring gene STARR-positive B cell enhancer ABC_E11131 Neighboring gene STARR-positive B cell enhancer mm9_chr2:43441000-43441301 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:43478445-43478746 Neighboring gene STARR-seq mESC enhancer starr_04386 Neighboring gene STARR-positive B cell enhancer ABC_E4451 Neighboring gene STARR-seq mESC enhancer starr_04387 Neighboring gene STARR-positive B cell enhancer ABC_E9513 Neighboring gene STARR-seq mESC enhancer starr_04388 Neighboring gene STARR-positive B cell enhancer ABC_E636 Neighboring gene predicted gene, 30374 Neighboring gene Rho GTPase activating protein 15 Neighboring gene predicted gene, 39804

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis. Kesarwani P, et al. Nat Commun, 2023 Mar 16. PMID 36927729, Free PMC Article
    2. Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect. Wang M, et al. J Cell Physiol, 2022 Jan. PMID 34553380
    3. De novo NAD(+) synthesis contributes to CD8(+) T cell metabolic fitness and antitumor function. Wan J, et al. Cell Rep, 2023 Dec 26. PMID 38041812
    4. Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis. Ito M, et al. J Dermatol Sci, 2004 Dec. PMID 15541637
    5. NAD Deficiency, Congenital Malformations, and Niacin Supplementation. Shi H, et al. N Engl J Med, 2017 Aug 10. PMID 28792876

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
      Title: Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
    2. Levels of mRNA for IDO (indoleamine 2,3-dioxygenase) and kynureninase, enzymes constituting the tryptophan degradation pathway, were found to be upregulated in the skin lesions of atopic dermatitis or psoriasis
      Title: Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kynureninase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynureninase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kynureninase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in anthranilate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anthranilate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anthranilate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in quinolinate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to vitamin B6 IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to vitamin B6 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophan catabolic process to acetyl-CoA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kynureninase
    Names
    L-kynurenine hydrolase
    NP_001276522.1
    NP_001276523.1
    NP_001385605.1
    NP_081828.2
    XP_011237480.1
    XP_011237481.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289593.1 → NP_001276522.1  kynureninase isoform 2

      See identical proteins and their annotated locations for NP_001276522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a 3' terminal exon which extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK050024, AK149423, AL845160
      Consensus CDS
      CCDS79792.1
      UniProtKB/TrEMBL
      F7BY26, Q6NSV5
      Related
      ENSMUSP00000108445.3, ENSMUST00000112826.8
      Conserved Domains (2) summary
      TIGR01814
      Location:31 → 426
      kynureninase; kynureninase
      cl18945
      Location:25 → 426
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. NM_001289594.1 → NP_001276523.1  kynureninase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK050024, AK149423, AL845336
      Consensus CDS
      CCDS79791.1
      UniProtKB/TrEMBL
      A2ARD7, Q8R0F7
      Related
      ENSMUSP00000061775.8, ENSMUST00000050511.7
      Conserved Domains (1) summary
      cl18945
      Location:25 → 303
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. NM_001398676.1 → NP_001385605.1  kynureninase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845160, AL845336
      UniProtKB/Swiss-Prot
      Q9CXF0
      Related
      ENSMUSP00000159520.1, ENSMUST00000240759.1
      Conserved Domains (1) summary
      TIGR01814
      Location:30 → 459
      kynureninase

    4. NM_027552.3 → NP_081828.2  kynureninase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL845160, AL845336
      Consensus CDS
      CCDS16018.1
      UniProtKB/Swiss-Prot
      Q9CXF0
      Related
      ENSMUSP00000028223.4, ENSMUST00000028223.10
      Conserved Domains (1) summary
      TIGR01814
      Location:30 → 459
      kynureninase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      43445270..43572734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239179.3 → XP_011237481.1  kynureninase isoform X3

      UniProtKB/TrEMBL
      A2ARD6
      Conserved Domains (1) summary
      TIGR01814
      Location:31 → 427
      kynureninase

    2. XM_011239178.1 → XP_011237480.1  kynureninase isoform X2

      UniProtKB/TrEMBL
      A2ARD6
      Conserved Domains (1) summary
      TIGR01814
      Location:31 → 436
      kynureninase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXF0.3 GenPept UniProtKB/Swiss-Prot:Q9CXF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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