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    Gmfb glia maturation factor, beta [ Mus musculus (house mouse) ]

    Gene ID: 63985, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gmfbprovided by MGI
    Official Full Name
    glia maturation factor, betaprovided by MGI
    Primary source
    MGI:MGI:1927133
    See related
    Ensembl:ENSMUSG00000062014 AllianceGenome:MGI:1927133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D14Ertd630e; 3110001H22Rik; 3110001O16Rik
    Summary
    Predicted to enable Arp2/3 complex binding activity. Acts upstream of or within learning and locomotory behavior. Predicted to be active in cortical actin cytoskeleton. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Orthologous to human GMFB (glia maturation factor beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 25.4), frontal lobe adult (RPKM 21.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gmfb in Genome Data Viewer
    Location:
    14 C1; 14 24.32 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47045606..47059711, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46808149..46822259, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E752 Neighboring gene cyclin dependent kinase inhibitor 3 Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7306 Neighboring gene STARR-positive B cell enhancer ABC_E5430 Neighboring gene cell growth regulator with ring finger domain 1 Neighboring gene predicted gene, 34934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Suppression of glia maturation factor expression prevents 1-methyl-4-phenylpyridinium (MPP⁺)-induced loss of mesencephalic dopaminergic neurons. Khan MM, et al. Neuroscience, 2014 Sep 26. PMID 25016212, Free PMC Article
    2. Diminished cytokine and chemokine expression in the central nervous system of GMF-deficient mice with experimental autoimmune encephalomyelitis. Zaheer A, et al. Brain Res, 2007 May 4. PMID 17316572, Free PMC Article
    3. Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage. Zaheer A, et al. Brain Res, 2008 May 7. PMID 18395194, Free PMC Article
    4. Overexpression of glia maturation factor reinstates susceptibility to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in glia maturation factor deficient mice. Zaheer S, et al. Neurobiol Dis, 2010 Dec. PMID 20696246, Free PMC Article
    5. Glia maturation factor deficiency suppresses 1-methyl-4-phenylpyridinium-induced oxidative stress in astrocytes. Khan MM, et al. J Mol Neurosci, 2014 Aug. PMID 24430624, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease.
      Title: G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease.
    2. Glia Maturation Factor-beta Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals.
      Title: Glia Maturation Factor-β Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals.
    3. Neuroinflammation Mediated by Glia Maturation Factor Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain Injury.
      Title: Neuroinflammation Mediated by Glia Maturation Factor Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain Injury.
    4. Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain Injury.
      Title: Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain Injury.
    5. A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice.
      Title: A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice.
    6. Our studies show that the absence of mast cells and GMF reduce the expression of neuroinflammatory mediators in the brain.
      Title: Glia Maturation Factor and Mast Cell-Dependent Expression of Inflammatory Mediators and Proteinase Activated Receptor-2 in Neuroinflammation.
    7. This is the first study to demonstrate the expression of GMF-beta in reactive glial cells and its association with neuropathology in toxoplasmic encephalitis.
      Title: First description of enhanced expression of glia maturation factor-beta in experimental toxoplasmic encephalitis.
    8. GMF transgenic mice might be a novel mouse model of accelerated aging, due to the abnormal lamin A
      Title: Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation.
    9. Deficiency of glia maturation factor protects the dopaminergic neuron loss in a model of parkinsonism.
      Title: Absence of glia maturation factor protects dopaminergic neurons and improves motor behavior in mouse model of parkinsonism.
    10. The data suggest that debranching by GMFbeta plays an important role in branched actin regulation, lamellipodial dynamics, and directional migration.
      Title: GMFβ controls branched actin content and lamellipodial retraction in fibroblasts.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament debranching IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament debranching IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glia maturation factor beta
    Names
    GMF-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022023.2 → NP_071306.2  glia maturation factor beta

      See identical proteins and their annotated locations for NP_071306.2

      Status: VALIDATED

      Source sequence(s)
      AC093043
      Consensus CDS
      CCDS36898.1
      UniProtKB/Swiss-Prot
      Q3UQX5, Q9CQI3, Q9ERL8
      UniProtKB/TrEMBL
      A0A2I3BPS1
      Related
      ENSMUSP00000107448.2, ENSMUST00000111817.8
      Conserved Domains (1) summary
      cd11283
      Location:9 → 130
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47045606..47059711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247909.2 → XP_030103769.1  glia maturation factor beta isoform X1

      UniProtKB/TrEMBL
      A0A2I3BPS1, Q80X87
      Conserved Domains (1) summary
      cd11283
      Location:9 → 131
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    2. XM_030247913.1 → XP_030103773.1  glia maturation factor beta isoform X3

      Conserved Domains (1) summary
      cd11283
      Location:1 → 97
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    3. XM_036158778.1 → XP_036014671.1  glia maturation factor beta isoform X3

      Conserved Domains (1) summary
      cd11283
      Location:1 → 97
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    4. XM_030247912.1 → XP_030103772.1  glia maturation factor beta isoform X3

      Conserved Domains (1) summary
      cd11283
      Location:1 → 97
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    5. XM_030247911.1 → XP_030103771.1  glia maturation factor beta isoform X3

      Conserved Domains (1) summary
      cd11283
      Location:1 → 97
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    6. XM_030247910.1 → XP_030103770.1  glia maturation factor beta isoform X2

      Conserved Domains (1) summary
      cd11283
      Location:1 → 98
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQI3.3 GenPept UniProtKB/Swiss-Prot:Q9CQI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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