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    Mpv17l2 MPV17 mitochondrial membrane protein-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 234384, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mpv17l2provided by MGI
    Official Full Name
    MPV17 mitochondrial membrane protein-like 2provided by MGI
    Primary source
    MGI:MGI:2681846
    See related
    Ensembl:ENSMUSG00000035559 AllianceGenome:MGI:2681846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fksg24
    Summary
    Predicted to be involved in mitochondrial ribosome assembly and positive regulation of mitochondrial translation. Located in mitochondrion. Is expressed in bone; genitourinary system; and gut. Orthologous to human MPV17L2 (MPV17 mitochondrial inner membrane protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 118.7), stomach adult (RPKM 57.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mpv17l2 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71211295..71213589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70758649..70760932, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34255 Neighboring gene phosphodiesterase 4C, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E1370 Neighboring gene RIKEN cDNA 6330537M06 gene Neighboring gene STARR-positive B cell enhancer ABC_E190 Neighboring gene RAB3A, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E10506 Neighboring gene interferon gamma inducible protein 30 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E8241

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63135

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mpv17-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183170.2 → NP_898993.1  mpv17-like protein 2

      See identical proteins and their annotated locations for NP_898993.1

      Status: PROVISIONAL

      Source sequence(s)
      CAAA01070179
      Consensus CDS
      CCDS22380.1
      UniProtKB/Swiss-Prot
      Q3THH2, Q80UR1, Q8VIK2
      Related
      ENSMUSP00000037929.9, ENSMUST00000038626.10
      Conserved Domains (1) summary
      pfam04117
      Location:124 → 186
      Mpv17_PMP22; Mpv17 / PMP22 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71211295..71213589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242299.3 → XP_011240601.1  mpv17-like protein 2 isoform X1

      Conserved Domains (1) summary
      pfam04117
      Location:28 → 89
      Mpv17_PMP22; Mpv17 / PMP22 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VIK2.1 GenPept UniProtKB/Swiss-Prot:Q8VIK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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