Sh3bgrl2 SH3 domain binding glutamic acid-rich protein like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sh3bgrl2provided by MGI
Official Full Name: SH3 domain binding glutamic acid-rich protein like 2provided by MGI
Primary source: MGI:MGI:1915350
See related: Ensembl:ENSMUSG00000032261 AllianceGenome:MGI:1915350
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B930089I21; A930014C21Rik
Summary: Predicted to enable SH3 domain binding activity. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in brain. Orthologous to human SH3BGRL2 (SH3 domain binding glutamate rich protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in colon adult (RPKM 3.6), bladder adult (RPKM 2.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E2; 9 45.49 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (83430391..83482345)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (83548338..83600292)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126548 (e-PCR)
- UniSTS:209678

NoName (e-PCR)
- UniSTS:236208

RH124662 (e-PCR)
- UniSTS:161484

RH126516 (e-PCR)
- UniSTS:209658

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH3 domain-binding glutamic acid-rich-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172507.5 → NP_766095.1 SH3 domain-binding glutamic acid-rich-like protein 2

See identical proteins and their annotated locations for NP_766095.1

Status: PROVISIONAL

Source sequence(s)

AC113158, AC125106

Consensus CDS

CCDS40708.1

UniProtKB/Swiss-Prot

Q3TV64, Q8BG73

UniProtKB/TrEMBL

A0A087WS96, Q8C073

Related

ENSMUSP00000108841.4, ENSMUST00000113215.10

Conserved Domains (1) summary

cd03030
Location:2 → 97

GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...