H2-Ob histocompatibility 2, O region beta locus [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-Obprovided by MGI
Official Full Name: histocompatibility 2, O region beta locusprovided by MGI
Primary source: MGI:MGI:95925
See related: Ensembl:ENSMUSG00000041538 AllianceGenome:MGI:95925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ob; H-2I; vic1; H-2Ab; H-2Ob; H2-Ab; H2-Ab2; A-beta2; H2-IAb2; A-beta-2
Summary: Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; and peptide antigen assembly with MHC class II protein complex. Predicted to be located in lysosome. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in hemolymphoid system and metanephros. Orthologous to human HLA-DOB (major histocompatibility complex, class II, DO beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 49.9), mammary gland adult (RPKM 16.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34457879..34464882)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34238905..34245908)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proper development of long-lived memory CD4 T cells requires HLA-DO function.
Title: Proper development of long-lived memory CD4 T cells requires HLA-DO function.
Mouse MHC class II chaperone H2-O antigen affects the repertoire of presented self-peptides by B cells and thymic epithelium. H2-O induces differential effects on epitope presentation and thymic selection, thereby altering CD4 T-cell precursor frequencies. Lack of H2-O increases autoreactivity and susceptibility to autoimmune disease development.
Title: Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases.
these results report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ strain; it encodes the beta subunit of the non-classical major histocompatibility complex class II (MHC-II)-like molecule H2-O, a negative regulator of antigen presentation
Title: Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.
H2-O predominantly inhibits antigen presentation in early endosomal compartments. Thus, H2-O appears to skew peptide loading to late endosomal/lysosomal compartments. This may favor presentation of antigens taken up by the B cell receptor.
Title: Downmodulation of antigen presentation by H2-O in B cell lines and primary B lymphocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Spontaneous (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484884

D17Dgm2 (e-PCR), detects polymorphism
- UniSTS:142113

D17Mit21 (e-PCR), detects polymorphism
- UniSTS:116652

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class II protein complex binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class II protein complex	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histocompatibility 2, O region beta locus

Names: H2-IA-beta-2 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010389.3 → NP_034519.2 histocompatibility 2, O region beta locus precursor

See identical proteins and their annotated locations for NP_034519.2

Status: VALIDATED

Source sequence(s)

AF027865, AK053233, AK155650, BY205160

Consensus CDS

CCDS37582.1

UniProtKB/TrEMBL

O35424, Q3U1X7

Related

ENSMUSP00000092985.4, ENSMUST00000095342.11

Conserved Domains (2) summary

pfam00969
Location:39 → 113

MHC_II_beta; Class II histocompatibility antigen, beta domain

cl11960
Location:123 → 214

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34457879..34464882

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523686.3 → XP_006523749.1 histocompatibility 2, O region beta locus isoform X1

See identical proteins and their annotated locations for XP_006523749.1

Conserved Domains (2) summary

cl03042
Location:1 → 42

MHC_II_beta; Class II histocompatibility antigen, beta domain

cl11960
Location:52 → 143

Ig; Immunoglobulin domain