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    Btaf1 B-TFIID TATA-box binding protein associated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 107182, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Btaf1provided by MGI
    Official Full Name
    B-TFIID TATA-box binding protein associated factor 1provided by MGI
    Primary source
    MGI:MGI:2147538
    See related
    Ensembl:ENSMUSG00000040565 AllianceGenome:MGI:2147538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAF170; E430027O22Rik
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA and transcription coregulator activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in several structures, including genitourinary system. Orthologous to human BTAF1 (B-TFIID TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.3), liver E14 (RPKM 5.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Btaf1 in Genome Data Viewer
    Location:
    19 C2; 19 32.02 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (36903479..36991457)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (36926079..37014057)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Neighboring gene STARR-seq mESC enhancer starr_46034 Neighboring gene VISTA enhancer mm1641 Neighboring gene STARR-seq mESC enhancer starr_46037 Neighboring gene STARR-positive B cell enhancer ABC_E11029 Neighboring gene STARR-seq mESC enhancer starr_46040 Neighboring gene STARR-positive B cell enhancer ABC_E4277 Neighboring gene STARR-seq mESC enhancer starr_46041 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene RIKEN cDNA A330032B11 gene Neighboring gene membrane associated ring-CH-type finger 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability. Wansleeben C, et al. Mech Dev, 2011 May-Jun. PMID 21419221
    2. Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals. Xue Y, et al. Mol Cell, 2017 Aug 17. PMID 28735899, Free PMC Article
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2 co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells.
      Title: Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.
    2. An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability
      Title: An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TATA-binding protein-associated factor 172
    Names
    BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, (Mot1 homolog, S. cerevisiae)
    TBP-associated factor 170

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080706.1 → NP_001074175.1  TATA-binding protein-associated factor 172

      Status: PROVISIONAL

      Source sequence(s)
      AC118931
      Consensus CDS
      CCDS37969.1
      UniProtKB/TrEMBL
      A0ZVB6, E9QAE3
      Related
      ENSMUSP00000097093.4, ENSMUST00000099494.4
      Conserved Domains (6) summary
      cd00046
      Location:1285 → 1434
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:1268 → 1584
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1643 → 1743
      Helicase_C; Helicase conserved C-terminal domain
      pfam12054
      Location:585 → 1050
      DUF3535; Domain of unknown function (DUF3535)
      pfam13513
      Location:402 → 453
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:351 → 376
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      36903479..36991457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161373.1 → XP_036017266.1  TATA-binding protein-associated factor 172 isoform X1

      UniProtKB/TrEMBL
      A0ZVB6
      Conserved Domains (4) summary
      COG0553
      Location:1073 → 1645
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      sd00044
      Location:196 → 221
      HEAT; HEAT repeat [structural motif]
      cd17999
      Location:1110 → 1347
      DEXHc_Mot1; DEXH-box helicase domain of Mot1
      pfam12054
      Location:430 → 895
      DUF3535; Domain of unknown function (DUF3535)

    2. XM_006526561.5 → XP_006526624.1  TATA-binding protein-associated factor 172 isoform X2

      UniProtKB/TrEMBL
      A0ZVB6
      Conserved Domains (4) summary
      COG0553
      Location:1026 → 1598
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      sd00044
      Location:149 → 174
      HEAT; HEAT repeat [structural motif]
      cd17999
      Location:1063 → 1300
      DEXHc_Mot1; DEXH-box helicase domain of Mot1
      pfam12054
      Location:383 → 848
      DUF3535; Domain of unknown function (DUF3535)

    3. XM_030250684.2 → XP_030106544.1  TATA-binding protein-associated factor 172 isoform X3

      UniProtKB/TrEMBL
      Q52KH4
      Conserved Domains (4) summary
      COG0553
      Location:456 → 1028
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      sd00044
      Location:335 → 363
      HEAT; HEAT repeat [structural motif]
      cd17999
      Location:493 → 730
      DEXHc_Mot1; DEXH-box helicase domain of Mot1
      pfam12054
      Location:1 → 278
      DUF3535; Domain of unknown function (DUF3535)

    4. XM_017318039.3 → XP_017173528.1  TATA-binding protein-associated factor 172 isoform X3

      UniProtKB/TrEMBL
      Q52KH4
      Conserved Domains (4) summary
      COG0553
      Location:456 → 1028
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      sd00044
      Location:335 → 363
      HEAT; HEAT repeat [structural motif]
      cd17999
      Location:493 → 730
      DEXHc_Mot1; DEXH-box helicase domain of Mot1
      pfam12054
      Location:1 → 278
      DUF3535; Domain of unknown function (DUF3535)
    Nucleotide Protein Strain
    Heading Accession and Version

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