Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmb9provided by MGI
Official Full Name: proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)provided by MGI
Primary source: MGI:MGI:1346526
See related: Ensembl:ENSMUSG00000096727 AllianceGenome:MGI:1346526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lmp2; Lmp-2; Ring12
Summary: Predicted to enable endopeptidase activity and proteasome binding activity. Acts upstream of or within antigen processing and presentation and response to bacterium. Part of proteasome core complex and spermatoproteasome complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); lymphoma; and renal cell carcinoma. Orthologous to human PSMB9 (proteasome 20S subunit beta 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 97.4), thymus adult (RPKM 90.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34401006..34406347, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34182030..34187330, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunoproteasome impairment via beta5i/LMP7-deletion leads to sustained pancreatic injury from experimental pancreatitis.
Title: Immunoproteasome impairment via β5i/LMP7-deletion leads to sustained pancreatic injury from experimental pancreatitis.
Expression of immunoproteasome subunits in the brains of Toxoplasma gondii-infected mice.
Title: Expression of immunoproteasome subunits in the brains of Toxoplasma gondii-infected mice.
Heterozygous missense variant of the proteasome subunit beta-type 9 causes neonatal-onset autoinflammation and immunodeficiency.
Title: Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency.
co-inhibition of LMP2 and LMP7 appears to be synergistic and advantageous for the treatment of autoimmune diseases.
Title: Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.
LMP2 is crucial for lymphocyte development and survival in the periphery. LMP2-deficient lymphocytes show impaired degradation of key BH3-only proteins, resulting in elevated levels of pro-apoptotic BIM and increased cell death.
Title: LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins.
Although treatment with IFN-gamma strongly induced the activation of STAT1 as a transcriptional activator, its target molecule, IRF1, was not clearly produced in Lmp2-deficient uterine smooth muscle cells.
Title: Uterine Leiomyosarcoma Tumorigenesis in Lmp2-deficient Mice: Involvement of Impaired Anti-oncogenic Factor IRF1.
down-regulation of IL-33 protein levels by IFN-gamma in pulmonary fibroblasts and in the lungs in vivo occurs through STAT1 and non-canonical use of the LMP2 proteasome
Title: IFN-γ directly controls IL-33 protein level through a STAT1- and LMP2-dependent mechanism.
Data show that knockdown of i-proteasome catalytic subunit PSMB9 by short hairpin RNA (shRNA) decreased the expression of both PSMB9 and PSMB8 without affecting other catalytic subunits of the proteasome.
Title: Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation.
LMP2 has a role as a tumor-suppressor and may have a role in uterine leiomyosarcoma therapy
Title: Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy.
In this study, we have identified how LMP2 can exert its function in Ag processing
Title: Why the structure but not the activity of the immunoproteasome subunit low molecular mass polypeptide 2 rescues antigen presentation.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14566 (e-PCR)
- UniSTS:181006

D17Dgm1 (e-PCR), detects polymorphism
- UniSTS:142112

D17Dgm4 (e-PCR), detects polymorphism
- UniSTS:142115

D17Dgm5 (e-PCR), detects polymorphism
- UniSTS:142116

D17Dgm6 (e-PCR), detects polymorphism
- UniSTS:142117

NoName (e-PCR)
- UniSTS:488278

D17Mit103 (e-PCR), detects polymorphism
- UniSTS:127940

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spermatoproteasome complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proteasome subunit beta type-9

Names: LMP-2d; large multifunctional protease 2; low molecular mass protein 2; macropain chain 7; multicatalytic endopeptidase complex chain 7; proteasome chain 7; proteasome subunit beta-1i; proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); proteosome beta 9 subunit; really interesting new gene 12 protein

NP_001400133.1

EC 3.4.25.1

NP_001400134.1

EC 3.4.25.1

NP_001400135.1

EC 3.4.25.1

NP_001400136.1

EC 3.4.25.1

NP_001400137.1

EC 3.4.25.1

NP_001400138.1

EC 3.4.25.1

NP_001400140.1

EC 3.4.25.1

NP_001400141.1

EC 3.4.25.1

NP_038613.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413204.1 → NP_001400133.1 proteasome subunit beta type-9 isoform 2

Status: VALIDATED

Source sequence(s)

CR974422

UniProtKB/TrEMBL

Q3TAR7, Q3U7A7
NM_001413205.1 → NP_001400134.1 proteasome subunit beta type-9 isoform 3

Status: VALIDATED

Source sequence(s)

CR974422

UniProtKB/TrEMBL

Q3TAR7, Q3U7A7
NM_001413206.1 → NP_001400135.1 proteasome subunit beta type-9 isoform 3

Status: VALIDATED

Source sequence(s)

CR974422

UniProtKB/TrEMBL

Q3TAR7, Q3U7A7
NM_001413207.1 → NP_001400136.1 proteasome subunit beta type-9 isoform 4

Status: VALIDATED

Source sequence(s)

CR974422

UniProtKB/TrEMBL

Q3TAR7, Q3U7A7
NM_001413208.1 → NP_001400137.1 proteasome subunit beta type-9 isoform 5

Status: VALIDATED

Source sequence(s)

CR974422
NM_001413209.1 → NP_001400138.1 proteasome subunit beta type-9 isoform 5

Status: VALIDATED

Source sequence(s)

CR974422
NM_001413211.1 → NP_001400140.1 proteasome subunit beta type-9 isoform 5

Status: VALIDATED

Source sequence(s)

CR974422
NM_001413212.1 → NP_001400141.1 proteasome subunit beta type-9 isoform 6

Status: VALIDATED

Source sequence(s)

CR974422
NM_013585.3 → NP_038613.1 proteasome subunit beta type-9 isoform 1

See identical proteins and their annotated locations for NP_038613.1

Status: VALIDATED

Source sequence(s)

CR974422

Consensus CDS

CCDS28642.1

UniProtKB/TrEMBL

A0A0R4J256, Q3TAR7, Q3U7A7

Related

ENSMUSP00000133499.2, ENSMUST00000174576.4

Conserved Domains (2) summary

COG0638
Location:13 → 219

PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]

cd03762
Location:21 → 207

proteasome_beta_type_6; proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...