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    Tbc1d22a TBC1 domain family, member 22a [ Mus musculus (house mouse) ]

    Gene ID: 223754, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tbc1d22aprovided by MGI
    Official Full Name
    TBC1 domain family, member 22aprovided by MGI
    Primary source
    MGI:MGI:1289265
    See related
    Ensembl:ENSMUSG00000051864 AllianceGenome:MGI:1289265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D15Ertd781e
    Summary
    Predicted to enable 14-3-3 protein binding activity; GTPase activator activity; and protein homodimerization activity. Predicted to be active in Golgi apparatus. Orthologous to human TBC1D22A (TBC1 domain family member 22A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 17.9), thymus adult (RPKM 16.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbc1d22a in Genome Data Viewer
    Location:
    15 E2; 15 40.56 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (86095502..86382704)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (86214411..86498503)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39412 Neighboring gene STARR-positive B cell enhancer ABC_E9422 Neighboring gene GRAM domain containing 4 Neighboring gene predicted gene 15722 Neighboring gene STARR-positive B cell enhancer mm9_chr15:86003680-86003981 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86012285-86012732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86013160-86013361 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86033071-86033180 Neighboring gene RIKEN cDNA 2810001A02 gene Neighboring gene ceramide kinase Neighboring gene STARR-positive B cell enhancer ABC_E7404 Neighboring gene STARR-seq mESC enhancer starr_39415 Neighboring gene predicted gene 15569 Neighboring gene predicted gene, 22818 Neighboring gene STARR-seq mESC enhancer starr_39416 Neighboring gene STARR-seq mESC enhancer starr_39418 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86165311-86165512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86216802-86216911 Neighboring gene STARR-seq mESC enhancer starr_39419 Neighboring gene predicted gene, 34965 Neighboring gene RIKEN cDNA 4930543I03 gene Neighboring gene predicted gene, 35118

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. van der Weyden L, et al. G3 (Bethesda), 2020 Jun 1. PMID 32245826, Free PMC Article
    2. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Sellier C, et al. EMBO J, 2016 Jun 15. PMID 27103069, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28337

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 14-3-3 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 22A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358062.2 → NP_001344991.1  TBC1 domain family member 22A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115755, AC146911, AC163400
      Conserved Domains (1) summary
      pfam00566
      Location:50 → 240
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. NM_001409162.1 → NP_001396091.1  TBC1 domain family member 22A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115755, AC116764, AC146911, AC163400

    3. NM_001409163.1 → NP_001396092.1  TBC1 domain family member 22A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115755, AC116764, AC146911, AC163400

    4. NM_001409164.1 → NP_001396093.1  TBC1 domain family member 22A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115755, AC116764, AC146911, AC163400

    5. NM_001409165.1 → NP_001396094.1  TBC1 domain family member 22A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC115755, AC116764, AC146911, AC163400

    6. NM_001409166.1 → NP_001396095.1  TBC1 domain family member 22A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC115755, AC116764, AC146911, AC163400

    7. NM_001409167.1 → NP_001396096.1  TBC1 domain family member 22A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115755, AC116764, AC146911, AC163400

    8. NM_145476.3 → NP_663451.2  TBC1 domain family member 22A isoform 1

      See identical proteins and their annotated locations for NP_663451.2

      Status: VALIDATED

      Source sequence(s)
      AC115755, AC116764, AC146911, AC163400
      Consensus CDS
      CCDS27729.1
      UniProtKB/Swiss-Prot
      Q3U268, Q3U3T0, Q8CA49, Q8R5A6
      Related
      ENSMUSP00000065721.9, ENSMUST00000063414.9
      Conserved Domains (1) summary
      smart00164
      Location:218 → 468
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      86095502..86382704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159365.1 → XP_036015258.1  TBC1 domain family member 22A isoform X1

      Conserved Domains (2) summary
      PRK10819
      Location:112 → 132
      PRK10819; transport protein TonB; Provisional
      pfam00566
      Location:278 → 468
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. XM_036159366.1 → XP_036015259.1  TBC1 domain family member 22A isoform X2

      Conserved Domains (2) summary
      smart00164
      Location:218 → 442
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PRK10819
      Location:112 → 132
      PRK10819; transport protein TonB; Provisional

    3. XM_036159367.1 → XP_036015260.1  TBC1 domain family member 22A isoform X3

      Conserved Domains (1) summary
      pfam00566
      Location:50 → 240
      RabGAP-TBC; Rab-GTPase-TBC domain

    RNA

    1. XR_004938824.1 RNA Sequence

    2. XR_004938825.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5A6.3 GenPept UniProtKB/Swiss-Prot:Q8R5A6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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