Trim35 tripartite motif-containing 35 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim35provided by MGI
Official Full Name: tripartite motif-containing 35provided by MGI
Primary source: MGI:MGI:1914104
See related: Ensembl:ENSMUSG00000022043 AllianceGenome:MGI:1914104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NC8; HLS5; Mair; mKIAA1098; 0710005M05Rik; A430106H13Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of myeloid cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; lung; and sensory organ. Orthologous to human TRIM35 (tripartite motif containing 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 102.9), adrenal adult (RPKM 97.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.44 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (66534474..66548873)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (66297025..66311424)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts.
Title: TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts.
TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure.
Title: TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure.
The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
Title: The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
Tripartite motif-containing 35 (TRIM35) is up-regulated in UUO-induced renal fibrosis animal model.
Title: Tripartite motif-containing 35 (TRIM35) is up-regulated in UUO-induced renal fibrosis animal model.
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Title: TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Data suggest that Trim35 (tripartite motif-containing 35) down-regulates type I interferon production in dendritic cells via toll-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
Title: TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.
C/EBPbeta may regulate preadipocyte proliferation through activation of banp and trim35.
Title: Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation.
isolated from monocytoid variant, but not parental J2E erythroleukemia cells; expressed in wide range of adult tissues; at different stages of embryogenesis, Hls5 was detected in the branchial arches, spinal cord, dorsal root ganglia, limb buds, and brain
Title: HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor.
a novel RING-B-box-coiled-coil (RBCC) protein that consists of an N-terminal RING finger, followed by a B-box zinc finger, a coiled-coil domain, and a B30.2 domain; cloning and characterization
Title: Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW046487 (e-PCR)
- UniSTS:165910

RH143250 (e-PCR)
- UniSTS:232497

NoName (e-PCR)
- UniSTS:237215

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of myeloid cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myeloid cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM35

Names: hemopoietic lineage switch protein 5; macrophage-derived apoptosis-inducing RBCC protein; protein Nc8; tripartite motif-containing protein 35

NP_084255.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029979.3 → NP_084255.2 E3 ubiquitin-protein ligase TRIM35

See identical proteins and their annotated locations for NP_084255.2

Status: VALIDATED

Source sequence(s)

AC140329, AF145374

Consensus CDS

CCDS27221.2

UniProtKB/Swiss-Prot

A6H681, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8C006, Q8VID4, Q9CW74, Q9D208

UniProtKB/TrEMBL

A0A0R4J031

Related

ENSMUSP00000022623.7, ENSMUST00000022623.13

Conserved Domains (4) summary

cd00021
Location:114 → 152

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam13863
Location:166 → 262

DUF4200; Domain of unknown function (DUF4200)

cl02614
Location:318 → 504

SPRY; SPRY domain

cl17238
Location:33 → 77

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain