Ralgapa2 Ral GTPase activating protein, alpha subunit 2 (catalytic) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ralgapa2provided by MGI
Official Full Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)provided by MGI
Primary source: MGI:MGI:3036245
See related: Ensembl:ENSMUSG00000037110 AllianceGenome:MGI:3036245
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P220; RGC2; AS250; pp250; A230067G21Rik
Summary: Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in cochlea; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory cortex mantle layer; and olfactory epithelium. Orthologous to human RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 4.9), subcutaneous fat pad adult (RPKM 4.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 71.33 cM

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (146079326..146354174, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (146239876..146512254, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.
Title: Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.
loss of RalGAP function has a distinct role in promoting progression from prostatic intraepithelial neoplasia to invasive adenocarcinoma.
Title: Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis.
study reports the identification and characterization of a Ral GAP complex (RG1, RGC2) that mediates the activation of RalA downstream of the PI 3-kinase/Akt pathway
Title: A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

RH126989 (e-PCR)
- UniSTS:207417

RH130597 (e-PCR)
- UniSTS:213881

RH125976 (e-PCR)
- UniSTS:162688

RH125411 (e-PCR)
- UniSTS:162233

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Ral protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within activation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of exocyst localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ral GTPase-activating protein subunit alpha-2

Names: 250 kDa substrate of Akt; ral GTPase-activating protein alpha subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033348.4 → NP_001028520.2 ral GTPase-activating protein subunit alpha-2 isoform 1

Status: VALIDATED

Source sequence(s)

AL845273, AL845430, AL935056

Consensus CDS

CCDS16831.2

UniProtKB/Swiss-Prot

A3KGS3, A3KGS5, B7ZCU9, Q3TZD9, Q4VA60, Q69ZM8, Q7TQL4, Q8BYP2

UniProtKB/TrEMBL

A0A0A0MQD7

Related

ENSMUSP00000105613.3, ENSMUST00000109986.9

Conserved Domains (1) summary

pfam02145
Location:1702 → 1874

Rap_GAP; Rap/ran-GAP
NM_001408200.1 → NP_001395129.1 ral GTPase-activating protein subunit alpha-2 isoform 2

Status: VALIDATED

Source sequence(s)

AL845273, AL845430, AL935056

UniProtKB/Swiss-Prot

A3KGS3, A3KGS5, B7ZCU9, Q3TZD9, Q4VA60, Q69ZM8, Q7TQL4, Q8BYP2

Related

ENSMUSP00000122039.2, ENSMUST00000131824.8
NM_001408201.1 → NP_001395130.1 ral GTPase-activating protein subunit alpha-2 isoform 3

Status: VALIDATED

Source sequence(s)

AL845273, AL845430, AL935056

UniProtKB/Swiss-Prot

A3KGS3, A3KGS5, B7ZCU9, Q3TZD9, Q4VA60, Q69ZM8, Q7TQL4, Q8BYP2

UniProtKB/TrEMBL

A0A2I3BPN8

Related

ENSMUSP00000153734.2, ENSMUST00000228797.2
NM_001408202.1 → NP_001395131.1 ral GTPase-activating protein subunit alpha-2 isoform 4

Status: VALIDATED

Source sequence(s)

AL845273, AL845430

Related

ENSMUST00000109982.9

RNA

NR_176472.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL935056

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

146079326..146354174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161998.1 → XP_036017891.1 ral GTPase-activating protein subunit alpha-2 isoform X3

Conserved Domains (1) summary

pfam02145
Location:852 → 1024

Rap_GAP; Rap/ran-GAP