Fut8 fucosyltransferase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fut8provided by MGI
Official Full Name: fucosyltransferase 8provided by MGI
Primary source: MGI:MGI:1858901
See related: Ensembl:ENSMUSG00000021065 AllianceGenome:MGI:1858901
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables alpha-(1->6)-fucosyltransferase activity. Acts upstream of or within several processes, including N-glycan fucosylation; cell surface receptor signaling pathway; and fibroblast migration. Predicted to be located in Golgi cisterna membrane. Is expressed in telencephalon. Used to study pulmonary emphysema. Orthologous to human FUT8 (fucosyltransferase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 7.1), cerebellum adult (RPKM 6.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 35.46 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (77284878..77522770)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (77237430..77475998)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway.
Title: Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway.
Loss of FUT8 in renal tubules ameliorates ischemia-reperfusion injury-induced renal interstitial inflammation transition to fibrosis via the TLR3-NF-kappaB pathway.
Title: Loss of FUT8 in renal tubules ameliorates ischemia-reperfusion injury-induced renal interstitial inflammation transition to fibrosis via the TLR3-NF-κB pathway.
The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.
Title: The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.
Up-regulation of FUT8 inhibits TGF-beta1-induced activation of hepatic stellate cells during liver fibrogenesis.
Title: Up-regulation of FUT8 inhibits TGF-β1-induced activation of hepatic stellate cells during liver fibrogenesis.
FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development.
Title: FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development.
Caveolin-1 upregulates Fut8 expression by activating the Wnt/beta-catenin pathway to enhance HCC cell proliferative and invasive ability.
Title: Caveolin-1 upregulates Fut8 expression by activating the Wnt/β-catenin pathway to enhance HCC cell proliferative and invasive ability.
Structural basis of substrate recognition and catalysis by fucosyltransferase 8.
Title: Structural basis of substrate recognition and catalysis by fucosyltransferase 8.
Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice.
Title: Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice.
Core fucosylation negatively regulates the states of neuroinflammation by modulating the sensitivity of microglia and astrocytes to inflammatory mediators. The disorders of Fut8(-/-) mice are caused not only by neurons but also by glial cell dysfunction.
Title: Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators.
our study provides the first direct evidence for the involvement of Fut8 in liver regeneration.
Title: Loss of α1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fut8 (e-PCR), detects polymorphism
- UniSTS:256668

AB025198 (e-PCR)
- UniSTS:163528

RH127620 (e-PCR)
- UniSTS:210930

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables alpha-(1->6)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->6)-fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycoprotein 6-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycoprotein 6-alpha-L-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in GDP-L-fucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GDP-L-fucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-glycan fucosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within N-glycan fucosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within N-glycan processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within receptor metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-(1,6)-fucosyltransferase

Names: GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; alpha1-6FucT; glycoprotein 6-alpha-L-fucosyltransferase

NP_001239543.1

EC 2.4.1.68

NP_001239544.1

EC 2.4.1.68

NP_001239545.1

EC 2.4.1.68

NP_058589.2

EC 2.4.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252614.1 → NP_001239543.1 alpha-(1,6)-fucosyltransferase isoform 1

See identical proteins and their annotated locations for NP_001239543.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an additional exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AC110302, AC132342, AC159296

Consensus CDS

CCDS25999.1

UniProtKB/Swiss-Prot

Q543F5, Q921U1, Q9WTS2

UniProtKB/TrEMBL

Q3UYN7

Related

ENSMUSP00000136327.2, ENSMUST00000177595.9

Conserved Domains (3) summary

cd11300
Location:174 → 499

Fut8_like; Alpha 1-6-fucosyltransferase

cd11792
Location:506 → 560

SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

pfam12718
Location:47 → 163

Tropomyosin_1; Tropomyosin like
NM_001252615.1 → NP_001239544.1 alpha-(1,6)-fucosyltransferase isoform 2

See identical proteins and their annotated locations for NP_001239544.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK048520, CJ320809, EF591874

UniProtKB/TrEMBL

B2X2D7

Related

ENSMUST00000219299.2

Conserved Domains (2) summary

cd11300
Location:11 → 336

Fut8_like; Alpha 1-6-fucosyltransferase

cd11792
Location:343 → 397

SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
NM_001252616.1 → NP_001239545.1 alpha-(1,6)-fucosyltransferase isoform 3

See identical proteins and their annotated locations for NP_001239545.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK048520, CJ320809, EF591875

UniProtKB/TrEMBL

B2X2D8

Related

ENSMUST00000218851.2

Conserved Domains (2) summary

cd11300
Location:10 → 310

Fut8_like; Alpha 1-6-fucosyltransferase

cd11792
Location:317 → 371

SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
NM_016893.5 → NP_058589.2 alpha-(1,6)-fucosyltransferase isoform 1

See identical proteins and their annotated locations for NP_058589.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.

Source sequence(s)

AK048520, AK051811, BU702757, CJ320809

Consensus CDS

CCDS25999.1

UniProtKB/Swiss-Prot

Q543F5, Q921U1, Q9WTS2

UniProtKB/TrEMBL

Q3UYN7

Related

ENSMUSP00000130845.3, ENSMUST00000171770.10

Conserved Domains (3) summary

cd11300
Location:174 → 499

Fut8_like; Alpha 1-6-fucosyltransferase

cd11792
Location:506 → 560

SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

pfam12718
Location:47 → 163

Tropomyosin_1; Tropomyosin like

RNA

NR_045554.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) has an alternate 5' exon, which contains an upstream ORF with a strong Kozak signal, compared to variant 1. The transcript is sufficiently abundant to represent as a RefSeq record, but is predicted to be non-coding because the upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK048520, AK051811, AK134537, CJ070536