Nwd1 NACHT and WD repeat domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nwd1provided by MGI
Official Full Name: NACHT and WD repeat domain containing 1provided by MGI
Primary source: MGI:MGI:2442268
See related: Ensembl:ENSMUSG00000048148 AllianceGenome:MGI:2442268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A230063L24Rik
Summary: Predicted to enable ATP binding activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity and positive regulation of gene expression. Predicted to be located in cytosol and nucleolus. Is expressed in several structures, including brain; cardiovascular system; ganglia; spinal cord ventricular layer; and spleen. Orthologous to human NWD1 (NACHT and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 6.0), frontal lobe adult (RPKM 5.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 35.08 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (73372865..73443508)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (72646225..72716880)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nwd1 might be involved in the neuronal lineage as a new STAND gene, including having a pro-apoptotic or nonapoptotic role, similar to Apaf1
Title: Expression profile of the STAND protein Nwd1 in the developing and mature mouse central nervous system.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

AI413399 (e-PCR)
- UniSTS:159776

NoName (e-PCR)
- UniSTS:235927

BF386951 (e-PCR)
- UniSTS:243895

fb33b12.x1 (e-PCR)
- UniSTS:190403

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT domain- and WD repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176940.5 → NP_795914.3 NACHT domain- and WD repeat-containing protein 1

Status: VALIDATED

Source sequence(s)

AK087622, BC082552

Consensus CDS

CCDS22418.2

UniProtKB/TrEMBL

A0A2I3BR96, E0CX99

Related

ENSMUSP00000124804.2, ENSMUST00000161254.9

Conserved Domains (4) summary

cd00009
Location:315 → 361

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG2319
Location:908 → 1286

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1217 → 1255

7WD40; WD40 repeat [structural motif]

cl02567
Location:860 → 1156

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

73372865..73443508

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154091.1 → XP_036009984.1 NACHT domain- and WD repeat-containing protein 1 isoform X8

Conserved Domains (4) summary

sd00039
Location:881 → 917

7WD40; WD40 repeat [structural motif]

cl29593
Location:870 → 920

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38936
Location:315 → 361

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl40481
Location:337 → 504

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
XM_036154092.1 → XP_036009985.1 NACHT domain- and WD repeat-containing protein 1 isoform X9

Conserved Domains (4) summary

sd00039
Location:871 → 907

7WD40; WD40 repeat [structural motif]

cl29593
Location:860 → 910

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38936
Location:315 → 361

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl40481
Location:337 → 504

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
XM_030243605.2 → XP_030099465.1 NACHT domain- and WD repeat-containing protein 1 isoform X5

UniProtKB/TrEMBL

B7ZMT4

Conserved Domains (5) summary

cd00009
Location:155 → 201

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG2319
Location:878 → 1311

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1109 → 1147

7WD40; WD40 repeat [structural motif]

cl29593
Location:710 → 1006

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38985
Location:177 → 344

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006531086.3 → XP_006531149.1 NACHT domain- and WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A2I3BR96

Conserved Domains (5) summary

cd00009
Location:315 → 361

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG2319
Location:1038 → 1471

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1269 → 1307

7WD40; WD40 repeat [structural motif]

cl29593
Location:870 → 1166

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38985
Location:337 → 504

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036154089.1 → XP_036009982.1 NACHT domain- and WD repeat-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A2I3BR96

Conserved Domains (5) summary

COG2319
Location:997 → 1430

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1228 → 1266

7WD40; WD40 repeat [structural motif]

cl29593
Location:867 → 1125

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38936
Location:315 → 361

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl40481
Location:337 → 504

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
XM_006531087.5 → XP_006531150.1 NACHT domain- and WD repeat-containing protein 1 isoform X2

See identical proteins and their annotated locations for XP_006531150.1

UniProtKB/Swiss-Prot

A6H603, Q3TRC9, Q8BS99

UniProtKB/TrEMBL

A0A2I3BR96

Related

ENSMUSP00000091135.5, ENSMUST00000093427.11

Conserved Domains (5) summary

cd00009
Location:315 → 361

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG2319
Location:1028 → 1461

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1259 → 1297

7WD40; WD40 repeat [structural motif]

cl29593
Location:860 → 1156

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38985
Location:337 → 504

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036154090.1 → XP_036009983.1 NACHT domain- and WD repeat-containing protein 1 isoform X4

UniProtKB/TrEMBL

A0A2I3BR96

Conserved Domains (5) summary

COG2319
Location:987 → 1420

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1218 → 1256

7WD40; WD40 repeat [structural motif]

cl29593
Location:857 → 1115

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38936
Location:315 → 361

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl40481
Location:337 → 504

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
XM_006531088.4 → XP_006531151.1 NACHT domain- and WD repeat-containing protein 1 isoform X6

See identical proteins and their annotated locations for XP_006531151.1

UniProtKB/TrEMBL

B7ZMT4

Conserved Domains (5) summary

cd00009
Location:108 → 154

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG2319
Location:831 → 1264

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1062 → 1100

7WD40; WD40 repeat [structural motif]

cl29593
Location:663 → 959

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38985
Location:130 → 297

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_030243607.2 → XP_030099467.1 NACHT domain- and WD repeat-containing protein 1 isoform X7

UniProtKB/TrEMBL

B7ZMT4

Conserved Domains (5) summary

cd00009
Location:108 → 154

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG2319
Location:821 → 1254

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1052 → 1090

7WD40; WD40 repeat [structural motif]

cl29593
Location:653 → 949

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38985
Location:130 → 297

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_030243606.2 → XP_030099466.1 NACHT domain- and WD repeat-containing protein 1 isoform X7

UniProtKB/TrEMBL

B7ZMT4

Conserved Domains (5) summary

cd00009
Location:108 → 154

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG2319
Location:821 → 1254

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1052 → 1090

7WD40; WD40 repeat [structural motif]

cl29593
Location:653 → 949

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38985
Location:130 → 297

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006531089.3 → XP_006531152.1 NACHT domain- and WD repeat-containing protein 1 isoform X6

See identical proteins and their annotated locations for XP_006531152.1

UniProtKB/TrEMBL

B7ZMT4

Conserved Domains (5) summary

cd00009
Location:108 → 154

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

COG2319
Location:831 → 1264

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1062 → 1100

7WD40; WD40 repeat [structural motif]

cl29593
Location:663 → 959

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl38985
Location:130 → 297

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

XR_003947304.2 RNA Sequence
XR_004934841.1 RNA Sequence
XR_003947305.2 RNA Sequence
XR_003947306.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001159403.1: Suppressed sequence

Description

NM_001159403.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.