Klf15 KLF transcription factor 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klf15provided by RGD
Official Full Name: KLF transcription factor 15provided by RGD
Primary source: RGD:70918
See related: EnsemblRapid:ENSRNOG00000017808 AllianceGenome:RGD:70918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to peptide. Predicted to be located in nuclear speck. Orthologous to human KLF15 (KLF transcription factor 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 109.6), Liver (RPKM 91.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (124522652..124535613)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (122965718..122978403)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (122364688..122377690)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis.
Title: Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis.
[KLF15/mTOR related proteins involved in effect of aerobic interval training on improving skeletal muscle lesions in rats with type 2 diabetes].
Title: [KLF15/mTOR related proteins involved in effect of aerobic interval training on improving skeletal muscle lesions in rats with type 2 diabetes].
Krupsilonppel-like factor 15 suppresses renal glomerular mesangial cell proliferation via enhancing P53 SUMO1 conjugation.
Title: Krϋppel-like factor 15 suppresses renal glomerular mesangial cell proliferation via enhancing P53 SUMO1 conjugation.
MiR-137-3p exacerbates the ischemia-reperfusion injured cardiomyocyte apoptosis by targeting KLF15.
Title: MiR-137-3p exacerbates the ischemia-reperfusion injured cardiomyocyte apoptosis by targeting KLF15.
Loss of cardiac KLF15 in chronic kidney disease induced left ventricular hypertrophy, is associated with trophic and fibrotic signaling.
Title: Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15.
Angiotensin II stimulation of transforming growth factor beta expression in the myocytes activated p38alpha kinase via TAK1 kinase, inhibiting KLF15 expression.
Title: Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents.
Ang II down-regulates KLF15 expression via the AT1 receptor, and KLF15 is likely to inhibit Ang II-induced CTGF expression by repressing the recruitment of the co-activator P/CAF to the CTGF promoter.
Title: KLF 15 Works as an Early Anti-Fibrotic Transcriptional Regulator in Ang II-Induced Renal Fibrosis via Down-Regulation of CTGF Expression.
Overexpression of KLF15 can partially rescue aortic remodeling and aortic dissection formation in animal models by inhibiting CTGF expression.
Title: KLF15 Overexpression Protects β-Aminopropionitrile-Induced Aortic Rupture in Rodent Model via Inhibiting Connective Tissue Growth Factor.
Resveratrol treatment induces KLF15 expression, which may, in part, explain its therapeutic efficacy to improve the cardiac phenotype following ischemic injury.
Title: Resveratrol-Mediated Expression of KLF15 in the Ischemic Myocardium is Associated with an Improved Cardiac Phenotype.
KLF15 is repressed after pressure overload and induces fibrotic changes in the heart.
Title: KLF15 is an essential negative regulatory factor for the cardiac remodeling response to pressure overload.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Krueppel-like factor 15

Names: Kruppel-like factor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053536.2 → NP_445988.2 Krueppel-like factor 15

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IB85, B2DBE3, Q5FVT6, Q9WTQ3

Conserved Domains (3) summary

COG5189
Location:318 → 400

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:322 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

cd21580
Location:3 → 320

KLF15_N; N-terminal domain of Kruppel-like factor 15

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

124522652..124535613

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108490.2 → XP_038964418.1 Krueppel-like factor 15 isoform X1

UniProtKB/TrEMBL

A6IB85, B2DBE3, Q5FVT6, Q9WTQ3

Conserved Domains (3) summary

COG5189
Location:318 → 400

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:322 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

cd21580
Location:3 → 320

KLF15_N; N-terminal domain of Kruppel-like factor 15
XM_063286783.1 → XP_063142853.1 Krueppel-like factor 15 isoform X1

UniProtKB/TrEMBL

A6IB85, B2DBE3, Q5FVT6, Q9WTQ3

Related

ENSRNOP00000024011.2, ENSRNOT00000024011.7
XM_017592934.3 → XP_017448423.1 Krueppel-like factor 15 isoform X1

UniProtKB/TrEMBL

A6IB85, B2DBE3, Q5FVT6, Q9WTQ3

Conserved Domains (3) summary

COG5189
Location:318 → 400

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:322 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

cd21580
Location:3 → 320

KLF15_N; N-terminal domain of Kruppel-like factor 15
XM_006236882.5 → XP_006236944.1 Krueppel-like factor 15 isoform X1

See identical proteins and their annotated locations for XP_006236944.1

UniProtKB/TrEMBL

A6IB85, B2DBE3, Q5FVT6, Q9WTQ3

Conserved Domains (3) summary

COG5189
Location:318 → 400

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:322 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

cd21580
Location:3 → 320

KLF15_N; N-terminal domain of Kruppel-like factor 15
XM_063286785.1 → XP_063142855.1 Krueppel-like factor 15 isoform X1

UniProtKB/TrEMBL

A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
XM_006236884.5 → XP_006236946.1 Krueppel-like factor 15 isoform X1

See identical proteins and their annotated locations for XP_006236946.1

UniProtKB/TrEMBL

A6IB85, B2DBE3, Q5FVT6, Q9WTQ3

Conserved Domains (3) summary

COG5189
Location:318 → 400

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:322 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

cd21580
Location:3 → 320

KLF15_N; N-terminal domain of Kruppel-like factor 15